CHRONIC LOW-BACK PAIN

This study tested a device called ReActiv8 that sends mild electrical pulses to muscles in the lower back. 203 adults with long-lasting, hard-to-treat low-back pain were randomly assigned to get the device or continue standard care. The main goal was to see if the device improved…

This study looked at people who still have low back pain after spinal surgery. Doctors tested a procedure called pulsed radiofrequency, given through a small tube near the spine, with or without steroids. The goal was to see if it reduces pain and improves daily life better than …

This study tested a biofeedback device that uses muscle signals to help people relax and retrain muscles. It included 330 adults with chronic low back pain, recent breast surgery pain, or migraines. Half used the device plus usual care; the other half had usual care alone. The go…

This study tested whether teaching people with chronic low back pain about the biology of pain (instead of just spinal anatomy) could reduce their disability. 88 adults with long-term back pain took part. The goal was to see if this approach, combined with rehab, works better tha…

This study tested a new way to help people with long-term low back pain. It combined virtual reality (VR) with guided imagery of acupuncture, without using real needles. 31 adults with chronic pain tried it. The goal was to see if people would stick with the treatment, how satisf…

This study looked at whether an antidepressant, physical therapy, or both together can help people with chronic low back pain who also have negative feelings like sadness or anxiety. About 308 adults aged 18-75 with back pain lasting over 6 months took part. The goal was to see i…

This study tested if prolotherapy (sugar water injections) can reduce pain and improve function in people with chronic low back pain from worn-out spine joints. Sixty adults aged 40-70 received either sugar water, steroid, or salt water injections. Researchers measured pain and d…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS), alone or combined with specific back exercises, can reduce pain and disability in people with chronic low back pain. 140 adults with long-lasting back …

This early-stage study tested an experimental drug called PP353 in 43 adults with chronic low back pain linked to a specific type of bone swelling (Modic 1). The main goals were to check safety and see if the drug reduces pain better than a placebo. Participants had to have at le…

This study tested whether using virtual reality (VR) at home can help people with long-term low back pain feel better and move more. Over 400 participants used one of three VR programs for 90 days. Researchers measured pain, daily function, and medication use through questionnair…

This study looked at whether adding dry cupping therapy to standard physiotherapy helps people with chronic low back pain more than a fake (sham) cupping treatment. 48 adults with pain lasting at least 3 months took part. The real cupping group had 10 sessions over about 3 weeks.…

This study tested whether teaching people about pain during light cycling helps chronic low back pain more than cycling alone. Twenty-four adults with long-term back pain took part. Both groups did light cycling, but one group also learned about how pain works. The goal was to se…

This study tested a new approach for people with long-term low back pain. Participants took a 1-hour class to understand how pain works, then did 30 minutes of exercise using virtual reality. The goal was to see if this combination could lower pain intensity, reduce fear of movem…

This study tested a special breathing program called Guided Respiration Mindfulness Therapy for adults with chronic low back pain. Nineteen people took part in 8 weekly one-hour breathing sessions. The goal was to see if the therapy was practical and liked by patients, and if it …

This study tested a web-based hypnosis app called Rose in 100 adults with chronic pain (including low back pain). Over 8 weeks, participants used the app and reported on pain, satisfaction, and usability. The goal was to see if the app is user-friendly and effective at improving …

This pilot study tested whether online mindfulness sessions could help people recover after lumbar spine surgery. 67 adults who had back surgery were randomly assigned to either mindfulness coaching or education sessions over 8 weeks. The main goals were to see if the program was…

This study tested whether a single injection of a patient's own concentrated platelets (PRP) into a damaged spinal disc could reduce pain and improve daily function in people with chronic low back pain. 126 adults with a specific type of disc inflammation (Modic 1) were randomly …

This study tested whether a drug called propranolol, normally used for heart conditions, could help adults with chronic low back pain or fibromyalgia when combined with pain education. The goal was to see if this approach is practical and acceptable, and to measure its effect on …

This study tested a new pain medication called HCP1004 against an existing one (RLD2401) in 310 adults with chronic low-back pain lasting at least 3 months. The goal was to see if the new drug works just as well and is safe. Participants rated their pain using a scale, and resear…

This study looked at a procedure called epiduroscopic adhesiolysis, which uses a tiny camera to see inside the spine and break up scar tissue, for people with long-term back and leg pain. It included 141 adults, some who had prior back surgery and some who had not. The goal was t…

This study tested a set of exercises called dynamic neuromuscular stabilization in 20 adults who had low back pain for at least six months. The goal was to see if these exercises could reduce pain, improve posture, and enhance daily life. Participants did the exercises and resear…

This study looked at whether custom-made foot orthoses (shoe inserts) can reduce chronic low back pain in people with pronated (flat) feet. 110 adults with both conditions were randomly given either custom orthoses or placebo inserts. The goal was to see if correcting foot postur…

This study looked at two different ways to help people with long-term low back pain: a pressure technique called ischemic compression and a special tape called kinesiology taping. Over 100 adults with back pain for at least 12 weeks took part. The goal was to see if adding these …

This study tested a mobile app called SleepFix that delivers behavioral therapy for insomnia in 106 adults with chronic low back pain and poor sleep. The goal was to see if using the app for 3 weeks could reduce how much pain interferes with daily life after 6 weeks. Participants…

This early-stage study tested whether an experimental oral drug called PIPE-791 is safe and can reduce pain in adults with long-term osteoarthritis knee pain or chronic low back pain. 43 participants stopped their usual pain medicines, then took either the study drug or a placebo…

This study tested whether a multidisciplinary biopsychosocial program (a team of experts addressing physical, emotional, and social factors) works better than standard multimodal care for chronic low back pain. 128 adults participated over 4 weeks. The goal was to reduce pain, di…

This study looked at whether acupuncture helps older adults (65 and older) with long-term low back pain feel better and move easier. Over 800 people took part, receiving either their usual care or acupuncture sessions over several months. The goal was to see if acupuncture reduce…

This study looked at how chronic low back pain changes the way people move. Researchers compared 70 participants—some with long-term back pain and some without—to measure their stability during bending and twisting motions. The goal was to better understand the physical effects o…

This study looked at 89 adults with chronic low back pain who joined a rehabilitation program. Researchers measured changes in physical activity and sitting time, and also explored what motivates patients to be active. The goal was to understand how rehab affects both behavior an…

This study looked at 494 people with long-term low back pain to find out which treatments work best for whom. Participants tried different approaches like mindfulness, physical therapy, acupressure, or medication. The goal was to learn more about how these treatments help, not to…

This pilot study looked at how people with chronic low back pain walk and whether a distraction task could change their walking pattern and reduce pain. 16 adults with long-term back pain walked at their normal speed and a faster speed, with and without a distraction. The goal wa…

This study enrolled 800 adults with new or ongoing neck or low back pain to find new biological and imaging markers. Researchers used X-rays and MRIs to look at spine changes and questionnaires to track disability. The goal was to better understand how pain develops and improve f…