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Could a heart drug rewire the brain to ease chronic pain?

NCT ID NCT05085782

Symptom relief Sponsor: Université de Sherbrooke Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new approach for chronic low-back pain and fibromyalgia in 48 adults. Participants received pain education plus propranolol (a blood pressure drug) to help the brain 'relearn' and reduce pain. The goal was to see if the treatment is feasible and acceptable, and to measure its effect on pain and function one month later.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

48 people

The number who actually took part.

Started

Feb 2022

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * French speaking * Suffering from \[chronic low back pain OR fibromyalgia\] for \>6 months * Average pain at least 4/10 * Central sensitization (assessed via a standardized physiotherapy evaluation and the Central Sensitization Inventory) Exclusion Criteria: * Health condition for which propranolol is contra-indicated * Medication with which co-administration of propranolol is contra-indicated * Severe or uncontrolled neurological/psychiatric condition (including post-traumatic stress disorder, substance abuse, suicidal ideation, etc.) * Surgery of the lower-back in the last 3 years * Litigation surrounding the painful condition

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Conditions

The condition(s) this trial relates to.

Chronic Pain fibromyalgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic low back pain Fibromyalgia

Contacts and locations

Locations

  • CRCHUS: Centre de recherche du centre hospitalier universitaire de Sherbrooke

    Sherbrooke, Quebec, J1H5N4, Canada

  • Centre de recherche sur le vieillissement (CdRV)

    Sherbrooke, Quebec, J1H 4C4, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.