FIBROMYALGIA

This study tests whether adding shiatsu therapy to usual medical care can improve quality of life for children and teens (ages 10-18) with chronic pain that is not caused by inflammation. About 40 participants will receive a 30-minute shiatsu session once a week for six weeks and…

This study compares taking pregabalin alone versus pregabalin plus toludesvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. About 384 adults with moderate to severe pain that hasn't improved with other treatments will participate. The goal is to see i…

This study tests whether a 6-week virtual reality exercise program can reduce the impact of fibromyalgia on daily life. 80 adults with fibromyalgia will either do exercises with immersive virtual reality or standard exercises without it. The goal is to see if the VR approach impr…

This study tests whether a walking program that combines outdoor walks, treadmill use, and a mobile app can improve heart and lung function and quality of life in women with fibromyalgia. About 54 participants aged 25-55 will be enrolled. The goal is to see if this approach helps…

This study looks at whether acupuncture can make opioid painkillers work better for people with fibromyalgia. About 45 adults who already take daily opioids for fibromyalgia pain will receive either real acupuncture or a sham (fake) version. Researchers will measure how much pain…

This study explores whether an 8-week program combining art, mindfulness, and body awareness in a university museum can reduce pain and improve quality of life for women with fibromyalgia. About 44 women will be randomly assigned to either the museum program or a control group. T…

This study compares the standard drug pregabalin alone versus pregabalin combined with dexmedetomidine for treating fibromyalgia, a condition causing widespread pain and fatigue. Researchers hope the combination will provide greater pain relief without more side effects. The tria…

This study tests whether a free online course can help people with multiple sclerosis, fibromyalgia, long COVID, or cancer-related fatigue adopt healthier diets and self-care habits. Researchers will measure changes in quality of life, fatigue, and mental health over time. The go…

This study is testing whether taking oral magnesium can reduce pain and other symptoms in people with fibromyalgia who have not responded to standard medications. Researchers will enroll 86 adults aged 18 to 65 and measure changes using a standard fibromyalgia questionnaire. The …

This study tests whether a non-invasive brain stimulation technique called deep rTMS can reduce chronic pain in people with nerve damage or fibromyalgia. About 70 adults with daily pain for at least 6 months will receive either real or sham (fake) treatment over 3 months. The goa…

This study tests whether MDMA-assisted therapy can reduce pain and improve quality of life in people with fibromyalgia, a chronic pain condition. Twenty adults will receive two therapy sessions with MDMA while researchers scan their brains to see how the drug affects pain signals…

This study is testing whether low, non-hallucinogenic doses of psilocybin (the active ingredient in magic mushrooms) can reduce pain in people with fibromyalgia, a condition causing widespread pain and fatigue. 35 adults will receive either a placebo or one of two low doses of ps…

This study tests a special hands-on therapy (osteopathic manual therapy) for jaw problems in people with fibromyalgia. About 114 adults with both conditions will receive the therapy to see if it reduces pain, improves jaw function, and lessens disability. The goal is to find a sa…

This study compares a video game-based exercise program (using Ring Fit Adventure on Nintendo Switch) to a standard home exercise program for women aged 30-70 with fibromyalgia. The goal is to see if the game makes exercise more enjoyable and effective at reducing pain, improving…

This study is testing whether herbal medicines and vitamin IV therapy can reduce symptoms of anxiety, fibromyalgia, arthritis, chronic pain, and high blood pressure. About 25 adults will receive natural treatments aimed at improving health and quality of life. The goal is to see …

This study looks at whether adding esketamine to usual fibromyalgia treatments can reduce pain more effectively and faster. About 92 adults with fibromyalgia who haven't gotten enough relief from standard care will take part. Researchers will compare pain scores between those get…

This study tests whether a hands-off therapy called energy healing can reduce pain and change brain activity in women with fibromyalgia. 25 participants will receive either real or sham (fake) energy healing while their brains are scanned with fMRI. The goal is to see if real ene…

This study tests a small, FDA-cleared device that gently stimulates nerves in the ear to reduce pain and improve daily function in 240 veterans with fibromyalgia. Half will get the real device, half a sham, and researchers will track pain levels and brain activity over 24 weeks. …

This study tests a new, noninvasive brain stimulation technique using ultrasound to reduce pain in people with fibromyalgia. 180 adults with fibromyalgia will receive four treatments over one month and complete surveys for 16 weeks. The goal is to see if this approach safely ease…

This study compares two medications, pregabalin and a newer drug called crisugabalin, to see which works better for fibromyalgia pain. Fibromyalgia causes widespread pain, fatigue, and emotional distress. The trial will include 1,116 adults with moderate to severe pain who haven'…

This study tests whether a digital sleep therapy program (Sleepio) can improve quality of life, sleep, and movement in adults with fibromyalgia who also have trouble sleeping. About 142 participants will use the program at home for 10 weeks or receive standard sleep advice. Resea…

This study is testing a special full-body suit that uses mild electrical pulses to help people with conditions like multiple sclerosis or fibromyalgia who suffer from muscle tightness, overactive reflexes, or pain. About 15 adults will try the suit to see if it improves balance a…

This small study at UC Irvine is testing whether core shamanism—a traditional healing practice—can reduce pain and other symptoms in women with fibromyalgia. About 25 participants will attend up to 5 shamanic sessions while researchers track pain levels, heart rate, breathing, an…

This study tests whether adding a gentle brain stimulation method called tDCS to a pain coping program helps people with fibromyalgia feel better. About 68 adults with fibromyalgia will take part. They will all go through education, then either real or fake tDCS, followed by exer…

This study tests a new drug-free approach for fibromyalgia pain. Researchers want to see if a short mental training session before acupuncture helps the patient's brain sync up with the clinician's brain, making the treatment more effective. The study will enroll 100 adults with …

This study tests a brief behavioral treatment delivered over Zoom for adults with fibromyalgia, lupus, chronic pelvic pain, or chronic low back pain. The goal is to help participants learn strategies to reduce pain, disability, and related issues like depression or anxiety. About…

This study tests two medications, pregabalin and mirogabalin, to see which one better reduces pain in people with fibromyalgia, a condition causing widespread pain and fatigue. About 674 adults with moderate to severe fibromyalgia will take one of the drugs and report their pain …

This study looks at whether a program that combines counseling and museum visits can help people with fibromyalgia, a condition causing widespread pain and emotional distress. Researchers will first assess participants' mental and physical health, then offer a therapy that includ…

This study looks at whether personalized physical training and a type of nerve stimulation can help reduce pain, improve sleep, and ease fatigue in people with fibromyalgia. About 75 adults with fibromyalgia and chronic fatigue will be split into three groups: one gets exercise p…

This study compares two different exercise programs plus dietary advice to see which better reduces symptoms in people who have both fibromyalgia and irritable bowel syndrome (IBS). Thirty adults aged 30 to 65 with moderate to severe IBS and confirmed fibromyalgia will participat…

This study compares pregabalin alone versus pregabalin plus venlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The trial will enroll 750 adults with moder…

This study tests an experimental drug called AXS-14 for managing fibromyalgia, a condition that causes widespread pain and fatigue. About 620 adults with fibromyalgia will take the drug or a placebo to see if it helps control symptoms longer. The main goal is to measure how long …

This study compares taking pregabalin alone versus pregabalin combined with desvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will involve 3…

This study looks at how fibromyalgia-related pain sensitivity (central sensitization) is linked to thinking and memory problems, often called 'fibro fog.' Researchers will assess 100 adults with fibromyalgia using questionnaires and cognitive tests. The goal is to better understa…

This study is testing whether the EXOPULSE Mollii Suit can improve balance and reduce fall risk in people with cerebral palsy, multiple sclerosis, stroke, or fibromyalgia. Researchers will track changes in balance scores and walking speed over time. The goal is to identify which …

This study aims to create a new, objective way to measure pain in children with juvenile idiopathic arthritis, lupus, or fibromyalgia. Researchers will collect data from 90 participants over one year to see if this pain measurement can help doctors choose the right treatment fast…

This study looks at how people with fibromyalgia or rheumatoid arthritis experience pain differently. Researchers will measure pressure pain thresholds in 150 adults to compare pain processing in these conditions. The goal is to better understand pain mechanisms, which could lead…

This study looks at how the brain and nerves contribute to long-term muscle and joint pain, such as arthritis, fibromyalgia, and back pain. Researchers will use a simple questionnaire and pain sensitivity tests to see if they can better diagnose and guide treatment. About 250 adu…

This study looks at two substances in the blood, S100B and BDNF, to see if they are linked to pain sensitivity and poor sleep in people with fibromyalgia. Researchers will compare 60 women with fibromyalgia to healthy women of the same age. The goal is to better understand what c…

This study looks at how different colors of light can change the way the brain processes pain. Researchers will use brain scans to compare people with chronic muscle or fibromyalgia pain to healthy volunteers. The goal is to understand the brain connections that make light a poss…

This study looks at how certain brain activity patterns, called explosive synchronization, relate to chronic pain in people with fibromyalgia. Researchers will compare brain scans of 150 participants (fibromyalgia patients and healthy volunteers) and test whether a gentle, non-in…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. Researchers want to see if those with pain and fatigue have higher levels of brain inflammation. The study does not …

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to see if daily changes in these factors can predict whether pain becomes long-term or flares up. A smaller group will also …

This study looks at how mood (like anxiety or positivity) and brain inflammation are connected to pain in veterans with fibromyalgia, a chronic pain condition. Researchers will measure pain, mood, and inflammation markers in 60 veterans. The goal is to use this information to cre…

This study looks at how long-term pain from knee problems or fibromyalgia changes the way nerves talk to muscles. Researchers will test pain sensitivity, muscle activity, and physical function in 135 adults aged 40 and older, including healthy volunteers. The goal is to better un…

This study looks at whether internet-based exposure-focused cognitive behavioral therapy (CBT) can change how the brain processes pain in people with fibromyalgia. About 50 adults with fibromyalgia will undergo pain tests before and after 10 weeks of online therapy. The goal is t…

This study tests whether people with fibromyalgia can learn to control their own brain activity using real-time brain scans (fMRI) to reduce pain. Participants will attend 8 weekly sessions with a pain psychologist and be assigned to either cognitive behavioral therapy or fibromy…

This study explores whether a sham (fake) neurofeedback system in a virtual reality environment can change brain wave patterns related to attention. Researchers will compare real-time brain activity in 35 adults with rumination, chronic pain, or fibromyalgia under three condition…