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Brain training may ease fibromyalgia pain, new study suggests

NCT ID NCT07023523

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether people with fibromyalgia can learn to control their own brain activity using real-time brain scans (fMRI) to reduce pain. Participants will either receive cognitive behavioral therapy or fibromyalgia education over 8 weeks. The goal is to see if self-regulating brain regions linked to pain can lead to lasting relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged 18-65 2. Meet the Wolfe et al 2011 research criteria for fibromyalgia for at least one year 3. On stable doses of medication prior to entering the study and agree not to change medications or dosages (or CAM treatments) during the trial 4. Baseline pain intensity of at least 4/10 on average and pain report for at least 50% of days 5. Able to provide written consent and fluent in English Exclusion Criteria: 1. Comorbid acute pain condition 2. Comorbid chronic pain condition that is rated by the subject as more painful than fibromyalgia 3. Stimulant medications for the fatigue associated with sleep apnea or shift work (e.g., modafinil), 4. Pregnant or nursing 5. Any psychiatric disorder involving a history of psychosis (e. g schizophrenia, severe personality disorders) 6. History of anxiety disorders or significant anxiety symptoms interfering with fMRI procedures (e.g., panic) 7. Contraindication to MRI (e.g., implanted ferrous metal) 8. History of significant head injury (e.g., with substantial loss of consciousness) 9. Psychiatric hospitalization in the past 6 months 10. Other contraindications to MRI 11. Participating in other therapeutic trials 12. Active suicidal ideation 13. Documented peripheral neuropathy of known cause (e.g diabetic neuropathy, chemotherapy-induced neuropathy, guillain-barre) 14. Routine or daily use of narcotics or substances of abuse 15. Autoimmune or inflammatory disease (RA, SLE, IBD) that causes pain 16. Lower Limb Vascular Surgery or Current Lower Limb Vascular Dysfunction 17. Any impairment, activity or situation that in the judgment of the Study Coordinator or Principal Investigator that would prevent satisfactory completion of the study protocol. This includes unreliable, or inconsistent pain scores as deemed by the principal investigator.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Athinoula A. Martinos Center for Biomedical Imaging

    RECRUITING

    Boston, Massachusetts, 02129, United States

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