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Could fibromyalgia pain be linked to damaged nerves?

NCT ID NCT06527183

Knowledge-focused Sponsor: Hospital Ambroise Paré Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study aims to find out how common small fiber neuropathy is in people with fibromyalgia compared to those with other chronic pain conditions and healthy volunteers. Researchers will use skin biopsies and other tests to check for nerve damage. The goal is to better understand the relationship between nerve health and pain in fibromyalgia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help clarify whether small fiber neuropathy is a key factor in fibromyalgia pain, potentially guiding future treatments.
What could go wrong
This is an observational study, not a treatment trial. It may find no clear link, and results may not change current care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2022

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with fibromyalgia, other chronic pains (nociplastic or nociceptive) and healthy subjects

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients over 18 years of age with no age limit - * having given their signed consent to take part in the study * affiliated to the French social security system * able to be followed for the entire duration of the study * reading and understanding French * accepting the principle of the study and able to comply with its conditions * suffering from chronic pain for at least six months of at least moderate intensity (≥ 4/10) * fibromyalgia detected by the FiRST questionnare and defined by the revised diagnostic criteria of the WHO or chronic nociceptive or nociplastic pain without associated fibromyalgia. * chronic pain for at least 6 months of at least moderate intensity (≥ 4/10) * untreated or with stable analgesic treatment for at least 2 weeks prior to inclusion- normal neurological examination at inclusion Exclusion Criteria: * litigation or compensation-seeking * cancer for less than 2 years * known cause of small-fiber neuropathy such as diabetes, systemic disease, hypothyroidism, alcohol, renal failure, genetic disease * clinical or EMG neuropathy * peripheral or central nervous system pathology with or without associated neuropathic pain * uncontrolled chronic pathology such as : morbid obesity, sleep apnea, uncontrolled hypertension, etc. - psychosis, previous suicide attempt * drug or psychoactive substance abuse * cognitive or psychological disorders incompatible with compliance with and/or understanding of the protocol * participation in another biomedical research protocol.

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Conditions

The condition(s) this trial relates to.

chronic pain syndrome fibromyalgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centre d'Evaluation et de Traitement de la douleur

    RECRUITING

    Paris, 75014, France

  • Inserm U987

    RECRUITING

    Boulogne-Billancourt, 92100, France

More trials for these conditions

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