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Back pain breakthrough? study tests best anesthetic dose for epidural shots

NCT ID NCT00887003

Symptom relief Sponsor: McMaster University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 252 adults with chronic low back pain to find the best volume and dose of local anesthetic when combined with a steroid in epidural injections. Participants received one of four dosing combinations over three injections in 12 months. Researchers measured pain relief, disability, anxiety, depression, and side effects to determine the optimal approach.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine (local anesthetic) and methylprednisolone (steroid)
What this could lead to
If successful, this could help doctors choose the best dose of anesthetic for longer-lasting pain relief with fewer side effects.
What could go wrong
This is a completed study comparing different doses, not testing a new drug. Results may not apply to all back pain patients, and some people may still get little relief or have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

252 people

The number who actually took part.

Started

May 2005

Finished

Sep 2011

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-75 years old * lower back pains \> 6 months * no lumbar epidural in past 6 months * no previous back surgery * written informed consent to participate in study Exclusion Criteria: * acute lower back pain * pregnancy * significant psychiatric disease * local or systemic infection * coagulopathy/anticoagulant therapy * bleeding diathesis * presently enrolled in another study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic low back pain

Contacts and locations

Locations

  • Hamilton General Hospital

    Hamilton, Ontario, Canada

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