New pill aims to tame ulcerative colitis Flare-Ups
NCT ID NCT07415044
First seen Feb 20, 2026 · Last updated Apr 30, 2026 · Updated 7 times
Summary
This study tests an oral medication called LY4268989 in about 1,400 adults with moderate to severe ulcerative colitis. The goal is to see if it can safely reduce symptoms and help the bowel heal compared to a placebo. Participants will take the pill for up to 108 weeks and be monitored for remission and side effects.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Antalya Egitim ve Arastırma Hastanesi
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Azienda Ospedaliera San Camillo Forlanini
NOT_YET_RECRUITINGRome, 00152, Italy
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NOT_YET_RECRUITINGSão Paulo, 01236030, Brazil
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NOT_YET_RECRUITINGItajaí, 88301-220, Brazil
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NOT_YET_RECRUITINGBinzhou, 256603, China
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NOT_YET_RECRUITINGToulouse, 31059, France
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RECRUITINGGreenville, North Carolina, 27834, United States
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Centro de Oncologia Leonardo Da Vinci - ATO Terapias
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Changhua Christian Hospital
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NOT_YET_RECRUITINGJerusalem, 9362410, Israel
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NOT_YET_RECRUITINGGyöngyös, 3200, Hungary
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Clinica de Investigacion en Reumatologia y Obesidad S. C.
NOT_YET_RECRUITINGGuadalajara, 44650, Mexico
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NOT_YET_RECRUITINGBarranquilla, 080020, Colombia
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Clinical Best Solutions
NOT_YET_RECRUITINGWarsaw, 00-710, Poland
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Clinical Research of Osceola
RECRUITINGKissimmee, Florida, 34741, United States
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Clinical Trials Service s.r.o.
NOT_YET_RECRUITINGUherské Hradiště, 686 01, Czechia
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Cliniq s.r.o.
NOT_YET_RECRUITINGBratislava, 81109, Slovakia
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Clinnova Research
NOT_YET_RECRUITINGAnaheim, California, 92805, United States
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NOT_YET_RECRUITINGPrague, 140 00, Czechia
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NOT_YET_RECRUITINGSão Paulo, 04543-011, Brazil
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NOT_YET_RECRUITINGVinnytsia, 21029, Ukraine
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DSI Research - Springboro
NOT_YET_RECRUITINGSpringboro, Ohio, 45066, United States
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NOT_YET_RECRUITINGLas Vegas, Nevada, 89128, United States
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ETG Siedlce
NOT_YET_RECRUITINGSiedlce, 08-110, Poland
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NOT_YET_RECRUITINGZamość, 22-400, Poland
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NOT_YET_RECRUITINGKyiv, 02002, Ukraine
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NOT_YET_RECRUITINGBornova, 35100, Turkey (Türkiye)
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Evangelismos General Hospital of Athens
NOT_YET_RECRUITINGAthens, 106 76, Greece
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Eximia Research-VA, LLC
RECRUITINGNorfolk, Virginia, 23502, United States
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First Affiliated Hospital of Kunming Medical University
NOT_YET_RECRUITINGKunming, 650032, China
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Florida Research Institute
RECRUITINGLakewood Rch, Florida, 34211, United States
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Fondazione Policlinico Tor Vergata
NOT_YET_RECRUITINGRome, 00133, Italy
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Fukuoka University Hospital
NOT_YET_RECRUITINGFukuoka, 814-0180, Japan
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NOT_YET_RECRUITINGBogotá, 110111, Colombia
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NOT_YET_RECRUITINGCaxias do Sul, 95070-560, Brazil
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NOT_YET_RECRUITINGBuenos Aires, C1425BGC, Argentina
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NOT_YET_RECRUITINGFort Worth, Texas, 76104, United States
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RECRUITINGGarland, Texas, 75044, United States
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NOT_YET_RECRUITINGSan Marcos, Texas, 78666, United States
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NOT_YET_RECRUITINGMansfield, Texas, 76063, United States
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GMC Clinical Research
NOT_YET_RECRUITINGFolsom, California, 95630, United States
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NOT_YET_RECRUITINGPrešov, 080 01, Slovakia
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NOT_YET_RECRUITINGVsetín, 755 01, Czechia
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NOT_YET_RECRUITINGBratislava, 821 01, Slovakia
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Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center
RECRUITINGWyoming, Michigan, 49519, United States
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RECRUITINGNew Albany, Indiana, 47150, United States
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NOT_YET_RECRUITINGLouisville, Kentucky, 40218, United States
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Gastrohub Hospital
NOT_YET_RECRUITINGPune, 411027, India
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General Hospital "Djordje Joanovic"
NOT_YET_RECRUITINGZrenjanin, 23000, Serbia
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Grand Teton Research Group
NOT_YET_RECRUITINGIdaho Falls, Idaho, 83404, United States
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Graphic Era Institute of Medical Sciences and Hospital
NOT_YET_RECRUITINGDehradun, 248008, India
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NOT_YET_RECRUITINGKatowice, 40-600, Poland
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NOT_YET_RECRUITINGCuritiba, Brazil
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Hacettepe Universite Hastaneleri
NOT_YET_RECRUITINGAnkara, 06230, Turkey (Türkiye)
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Health Sciences North
NOT_YET_RECRUITINGGreater Sudbury, P3E 5J1, Canada
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NOT_YET_RECRUITINGHradec Králové, 500 12, Czechia
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NOT_YET_RECRUITINGRosario, 2002, Argentina
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Humanitas
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NOT_YET_RECRUITINGPrague, 19000, Czechia
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NOT_YET_RECRUITINGBloemfontein, 9301, South Africa
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NOT_YET_RECRUITINGHaeundae-gu, 48108, South Korea
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Instituto Médico de Alta Complejidad San Isidro Sa
NOT_YET_RECRUITINGSan Isidro, 1642, Argentina
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Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
NOT_YET_RECRUITINGMexico City, 14080, Mexico
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Integrity Advanced Therapeutics
NOT_YET_RECRUITINGHouston, Texas, 77090, United States
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Ippokrateio General Hospital of Thessaloniki
NOT_YET_RECRUITINGThessaloniki, 54642, Greece
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Irmandade da Santa Casa da Misericórdia de Santos
NOT_YET_RECRUITINGSantos, 11075-900, Brazil
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Juntendo University Hospital
NOT_YET_RECRUITINGBunkyō City, 113-8431, Japan
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K2 Medical Research - Daytona Beach
NOT_YET_RECRUITINGDaytona Beach, Florida, 32114, United States
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NOT_YET_RECRUITINGSt Louis, Missouri, 63123, United States
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KLES Dr. Prabhakar Kore Hospital & M.R.C
NOT_YET_RECRUITINGBelagavi, Belagavi, 590010, India
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Kangbuk Samsung Hospital
NOT_YET_RECRUITINGSeoul, 03181, South Korea
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Kaohsiung Medical University Chung-Ho Memorial Hospital
NOT_YET_RECRUITINGKaohsiung City, 807, Taiwan
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Keystone Clinical Trials
NOT_YET_RECRUITINGMexico City, 06100, Mexico
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Klaipeda University Hospital
NOT_YET_RECRUITINGKlaipėda, 92288, Lithuania
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Klinički Bolnički Centar Split
NOT_YET_RECRUITINGSplit, 21000, Croatia
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NOT_YET_RECRUITINGZagreb, 10000, Croatia
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Kocaeli University Medical Faculty Hospital
NOT_YET_RECRUITINGİzmit, 41380, Turkey (Türkiye)
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NOT_YET_RECRUITINGTatabánya, 2800, Hungary
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Kyorin University Hospital
NOT_YET_RECRUITINGMitaka, 181-8611, Japan
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Kyung Hee University Hospital
NOT_YET_RECRUITINGSeoul, 02447, South Korea
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Kyungpook National University Hospital
NOT_YET_RECRUITINGJunggu, 41944, South Korea
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Lakeshore Hospital
NOT_YET_RECRUITINGKochi, 682040, India
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Lenasia Clinical Trial Centre - Johannesburg
NOT_YET_RECRUITINGJohannesburg, 1821, South Africa
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Leskovac General Hospital
NOT_YET_RECRUITINGLeskovac, 16000, Serbia
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Liaocheng People's Hospital
NOT_YET_RECRUITINGLiaocheng, 252000, China
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Liepjas reionl slimnca
NOT_YET_RECRUITINGLiepāja, LV-3414, Latvia
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Lifepoint Multispeciality Hospital
NOT_YET_RECRUITINGPune, 411057, India
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Loema Instituto de Pesquisa Clinica
NOT_YET_RECRUITINGCampinas, 13092-133, Brazil
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London Digestive Disease Institute
NOT_YET_RECRUITINGLondon, N6K 1M6, Canada
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M2M Med
NOT_YET_RECRUITINGChorzów, 41-500, Poland
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MEDICON
NOT_YET_RECRUITINGPrague, 140 00, Czechia
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MSB General Hospital
NOT_YET_RECRUITINGBelgrade, 11000, Serbia
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Mahavir Hospital & Research Centre - Hyderabad
NOT_YET_RECRUITINGHyderabad, 500004, India
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Mautalen Salud e Investigación
NOT_YET_RECRUITINGBuenos Aires, C1128AAF, Argentina
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Mayo Clinic in Rochester, Minnesota
NOT_YET_RECRUITINGRochester, Minnesota, 55905, United States
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Medbud Clinic
NOT_YET_RECRUITINGKyiv, 03037, Ukraine
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Medical Center Ok!Clinic+
NOT_YET_RECRUITINGKyiv, 02091, Ukraine
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Medical Center of Limited Liability Company "Medical Center "Consilium Medical"
NOT_YET_RECRUITINGKiev, 04050, Ukraine
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Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś
NOT_YET_RECRUITINGWarsaw, 04-501, Poland
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Medical Research Center of Connecticut
NOT_YET_RECRUITINGHamden, Connecticut, 06518, United States
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Medical University of South Carolina
NOT_YET_RECRUITINGCharleston, South Carolina, 29425, United States
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Mediclinic Panorama
NOT_YET_RECRUITINGCape Town, 7500, South Africa
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Meihekou Central Hospital
NOT_YET_RECRUITINGMeihekou, 135000, China
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Meir Medical Center
NOT_YET_RECRUITINGKfar Saba, 4428164, Israel
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Mersin University
NOT_YET_RECRUITINGMersin, 33110, Turkey (Türkiye)
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Midas Multispeciality Hospital Pvt.Ltd.
NOT_YET_RECRUITINGNagpur, 440010, India
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Midwest Digestive Health & Nutrition
NOT_YET_RECRUITINGDes Plaines, Illinois, 60016, United States
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Motilal Nehru Medical College Hospital
NOT_YET_RECRUITINGAllahābād, 211002, India
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Municipal Nonprofit Enterprise of Kyiv Region Council "Kyiv Regional Clinical Hospital"
NOT_YET_RECRUITINGKyiv, 04106, Ukraine
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Mustafa Kemal Universitesi
NOT_YET_RECRUITINGHatay, 31030, Turkey (Türkiye)
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National Hospital Organization Hirosaki General Medical Center
NOT_YET_RECRUITINGHirosaki, 036-8545, Japan
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National Taiwan University Hospital
NOT_YET_RECRUITINGTaipei, 10002, Taiwan
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Nemocnice AGEL Šternberk
NOT_YET_RECRUITINGSternberk, 785 01, Czechia
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Nemocnice Pardubického kraje
NOT_YET_RECRUITINGPardubice, 532 03, Czechia
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Nemocnice Slany
NOT_YET_RECRUITINGSlaný, 274 01, Czechia
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Northwestern University
NOT_YET_RECRUITINGChicago, Illinois, 60611, United States
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Ohio State University
NOT_YET_RECRUITINGHilliard, Ohio, 43026, United States
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Okayama University Hospital
NOT_YET_RECRUITINGOkayama, 700-8558, Japan
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Om Research LLC
NOT_YET_RECRUITINGTemple City, California, 91780, United States
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Om Research LLC
NOT_YET_RECRUITINGVictorville, California, 92395, United States
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One of a Kind Clinical Research Center
NOT_YET_RECRUITINGScottsdale, Arizona, 85258, United States
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Oslomed Centrum Medyczne
NOT_YET_RECRUITINGKrakow, 31-228, Poland
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Ospedale Di Circolo
NOT_YET_RECRUITINGRho, 20017, Italy
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Ospedale Isola Tiberina - Gemelli Isola
NOT_YET_RECRUITINGRome, 00186, Italy
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Ospedale San Raffaele
NOT_YET_RECRUITINGMilan, 20132, Italy
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Pacific Medical College & Hospital
NOT_YET_RECRUITINGUdaipur, 313001, India
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Pan American Center for Oncology Trials - Ciudadela
NOT_YET_RECRUITINGSan Juan, 00909, Puerto Rico
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Pauls Stradins Clinical Univeristy Hospital
NOT_YET_RECRUITINGRiga, LV-1002, Latvia
Contact
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Peak Gastroenterology Associates
RECRUITINGColorado Springs, Colorado, 80907, United States
Contact Phone: •••-•••-••••
Contact
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Peking University Shenzhen Hospital
NOT_YET_RECRUITINGShenzhen, 518036, China
Contact
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Poliklinika MEDICO - Rijeka
NOT_YET_RECRUITINGRijeka, 51000, Croatia
Contact
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Poliklinika Solmed
NOT_YET_RECRUITINGZagreb, 10000, Croatia
Contact
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Polimedica PTG Kielce
NOT_YET_RECRUITINGKielce, 25-355, Poland
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Principle Research Solutions
NOT_YET_RECRUITINGSpokane, Washington, 99202, United States
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Private Practice - Dr. Adriana Sánchez
NOT_YET_RECRUITINGGuadalajara, 44670, Mexico
Contact
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Proactive CR México SA de CV
NOT_YET_RECRUITINGIrapuato, 36520, Mexico
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Progastro Clinic
NOT_YET_RECRUITINGLviv, 79019, Ukraine
Contact Phone: •••-•••-••••
Contact
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Providence Sacred Heart Medical Center & Children's Hospital
NOT_YET_RECRUITINGSpokane, Washington, 99208, United States
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Contact
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Pusan National University Yangsan Hospital
NOT_YET_RECRUITINGBusan, 50612, South Korea
Contact
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QEII Health Sciences Centre - Victoria General Site
NOT_YET_RECRUITINGHalifax, B3H 2Y9, Canada
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Rambam Health Care Campus
NOT_YET_RECRUITINGHaifa, 3109601, Israel
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Renmin Hospital of Wuhan University
NOT_YET_RECRUITINGWuhan, 430060, China
Contact
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Rocky Mountain Gastroenterology Associates - Lakewood
NOT_YET_RECRUITINGLakewood, Colorado, 80228, United States
Contact
-
Rush University Medical Center
NOT_YET_RECRUITINGChicago, Illinois, 60612, United States
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SR Kalla Memorial Gastro & General Hospital
NOT_YET_RECRUITINGJaipur, 302001, India
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Contact
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Sai Gastroenterology/Proctology Clinic
NOT_YET_RECRUITINGFujiidera, 583-0027, Japan
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Saint Peter's University Hospital
NOT_YET_RECRUITINGNew Brunswick, New Jersey, 08901, United States
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Saiseikai Niigata Hospital
NOT_YET_RECRUITINGNiigata, 950-1104, Japan
Contact Phone: •••-•••-••••
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Sameshima Hospital
NOT_YET_RECRUITINGKagoshima, 892-0846, Japan
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Samsung Medical Center
NOT_YET_RECRUITINGSeoul, 06351, South Korea
Contact
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Sanford USD Medical Center
NOT_YET_RECRUITINGSioux Falls, South Dakota, 57105, United States
Contact
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Santa Familia PTG Lodz
NOT_YET_RECRUITINGLodz, 90-302, Poland
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Sapporo Higashi Tokushukai Hospital
NOT_YET_RECRUITINGSapporo, 065-0033, Japan
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Scientia Investigacion Clinica S.C.
NOT_YET_RECRUITINGChihuahua City, 31207, Mexico
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Scientia Investigacion Clinica Tj
NOT_YET_RECRUITINGCiudad de Tijuana, 22105, Mexico
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Semmelweis University
NOT_YET_RECRUITINGBudapest, 1083, Hungary
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Seoul National University Hospital
NOT_YET_RECRUITINGSeoul, 03080, South Korea
Contact Phone: •••-•••-••••
Contact
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Servicios de Oncología Médica Integral - Monterrey
NOT_YET_RECRUITINGMonterrey, 66220, Mexico
Contact
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Severance Hospital, Yonsei University Health System
NOT_YET_RECRUITINGSeoul, 03722, South Korea
Contact
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Shanghai Pudong New District Zhoupu Hospital
NOT_YET_RECRUITINGShanghai, 201318, China
Contact
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Shanghai Tenth People's Hospital
NOT_YET_RECRUITINGShanghai, 200072, China
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Sichuan Provincial People's Hospital
NOT_YET_RECRUITINGChengdu, 610072, China
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Contact
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Sonomed Sp. z o. o.
NOT_YET_RECRUITINGSzczecin, 71-685, Poland
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Southern Star Research Institute
NOT_YET_RECRUITINGSan Antonio, Texas, 78229, United States
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Spoke Research
NOT_YET_RECRUITINGCape Town, 7700, South Africa
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Springfield Clinic - First
RECRUITINGSpringfield, Illinois, 62702, United States
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Sremska Mitrovica Health Centre
NOT_YET_RECRUITINGSremska Mitrovica, 22000, Serbia
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Stat Research S.A.
NOT_YET_RECRUITINGBuenos Aires, C1023AAB, Argentina
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Stony Brook University
NOT_YET_RECRUITINGStony Brook, New York, 11794, United States
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Swedish Medical Center
NOT_YET_RECRUITINGSeattle, Washington, 98104, United States
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Taian City Central Hospital
NOT_YET_RECRUITINGTaian, 271000, China
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Contact
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The Affiliated Hospital of Qingdao University
NOT_YET_RECRUITINGQingdao, 266003, China
Contact
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The Catholic University of Korea, Daejeon St. Mary's Hospital
NOT_YET_RECRUITINGDaejeon, 34943, South Korea
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Contact
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The Catholic University of Korea, Eunpyeong St. Mary's Hospital
NOT_YET_RECRUITINGSeoul, 03312, South Korea
Contact
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The First Affiliated Hospital of Anhui Medical University
NOT_YET_RECRUITINGHefei, 230022, China
Contact
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The First Affiliated Hospital of Soochow University
NOT_YET_RECRUITINGSuzhou, 215006, China
Contact
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The First People's Hospital of Foshan
NOT_YET_RECRUITINGFoshan, 528041, China
Contact
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The Oregon Clinic
NOT_YET_RECRUITINGPortland, Oregon, 97220, United States
Contact
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The Sixth Affiliated Hospital of Sun Yat-sen University
NOT_YET_RECRUITINGGuangzhou, 510655, China
Contact
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The University of Osaka Hospital
NOT_YET_RECRUITINGSuita, 565-0871, Japan
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Contact
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Thoracic General Hospital of Athens "I Sotiria"
NOT_YET_RECRUITINGAthens, 115 27, Greece
Contact Phone: •••-•••-••••
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Tokitokai Tokito Clinic Coloproctology Center
NOT_YET_RECRUITINGSaitama, 336-0963, Japan
Contact Phone: •••-•••-••••
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Tokyo Yamate Medical Center
NOT_YET_RECRUITINGTokyo, 169-0073, Japan
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Topiwala National Medical College & B. Y. L. Nair Charitable Hospital
NOT_YET_RECRUITINGMumbai, 400008, India
Contact
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Transcarpathian Regional Hospital im.Andriya Novak
NOT_YET_RECRUITINGUzhhorod, 88018, Ukraine
Contact Phone: •••-•••-••••
Contact
-
Treasure Valley Medical Research
NOT_YET_RECRUITINGBoise, Idaho, 83706, United States
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Tri-Service General Hospital
NOT_YET_RECRUITINGTaipei, 114, Taiwan
Contact
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Tsujinaka Hospital - Kashiwanoha
NOT_YET_RECRUITINGKashiwa, 273-0011, Japan
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Contact
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Twoja Przychodnia PCM
NOT_YET_RECRUITINGPoznan, 60-324, Poland
Contact Phone: •••-•••-••••
Contact
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Twoja Przychodnia SCM
NOT_YET_RECRUITINGSzczecin, 71-434, Poland
Contact Phone: •••-•••-••••
Contact
-
Tyler Research Institute
NOT_YET_RECRUITINGTyler, Texas, 75701, United States
Contact Phone: •••-•••-••••
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-
Unidade Local de Saúde Entre o Douro e Voga
NOT_YET_RECRUITINGSanta Maria da Feira, 4520-211, Portugal
Contact Phone: •••-•••-••••
Contact
-
University General Hospital of Heraklion
NOT_YET_RECRUITINGHeraklion, 711 10, Greece
Contact Phone: •••-•••-••••
Contact
-
VCA poliklīnika Aura
NOT_YET_RECRUITINGRiga, LV-1035, Latvia
Contact
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Valleywise Health Medical Center
NOT_YET_RECRUITINGPhoenix, Arizona, 85008, United States
Contact Phone: •••-•••-••••
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-
Viesoji Istaiga Klaipedos Miesto Poliklinika
NOT_YET_RECRUITINGKlaipėda, 93200, Lithuania
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Contact
-
Virtua Health & Wellness Center - Moorestown
NOT_YET_RECRUITINGMoorestown, New Jersey, 08057, United States
Contact
-
Vseobecna nemocnica Rimavska Sobota
NOT_YET_RECRUITINGRimavská Sobota, 979 01, Slovakia
Contact Phone: •••-•••-••••
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-
Washington Gastroenterology - Tacoma
RECRUITINGTacoma, Washington, 98405, United States
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Contact
-
Wilmington Health, PLLC
NOT_YET_RECRUITINGWilmington, North Carolina, 28401, United States
Contact
-
Wonju Severance Christian Hospital
NOT_YET_RECRUITINGWŏnju, 26426, South Korea
Contact
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Wuhan Union Hospital
NOT_YET_RECRUITINGWuhan, 430022, China
Contact
-
Yatharth Super Speciality Hospital - Noida Extension
NOT_YET_RECRUITINGNoida, 201306, India
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Yeungnam Univeristy Medical Center
NOT_YET_RECRUITINGGyeongsan-si, 42415, South Korea
Contact Phone: •••-•••-••••
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-
Yitzhak Shamir Medical Center
NOT_YET_RECRUITINGẔerifin, 7033001, Israel
Contact Phone: •••-•••-••••
Contact
-
Yuebei People's Hospital Guangdong
NOT_YET_RECRUITINGShaoguan, 512026, China
Contact
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Zunyi Medical College - No.1 Affiliated Hospital
NOT_YET_RECRUITINGZunyi, 563003, China
Contact
-
Óbudai Egészségügyi Centrum
NOT_YET_RECRUITINGBudapest, 1036, Hungary
Contact Phone: •••-•••-••••
Contact
Conditions
Explore the condition pages connected to this study.