ULCERATIVE COLITIS (UC)

This study tests whether adding a special diet called the Crohn's Disease Exclusion Diet (CDED) to standard anti-TNF medication can improve symptom control in adults with active Crohn's disease or ulcerative colitis. About 80 participants will be split into two groups: one gets m…

This study looks at how well ozanimod works compared to azathioprine for people with steroid-dependent ulcerative colitis. Researchers will track 150 adults in Japan to see which treatment helps patients achieve remission without needing steroids. The goal is to find a safer, mor…

This study looks at whether adding a second drug (vedolizumab) to the standard drug upadacitinib works better than upadacitinib alone for people with moderate-to-severe ulcerative colitis. Researchers will review medical records from 150 adults across six hospitals in China to se…

This study tests an oral medication called LY4268989 for adults with moderate to severe ulcerative colitis. About 1,431 participants will receive either the drug or a placebo to see if it can reduce symptoms and inflammation. The study lasts about 2 years and requires regular che…

This study tests a new drug called BCD-261 in people with moderate to severe ulcerative colitis who haven't responded well to other treatments. About 198 adults will receive either BCD-261 or a placebo to see if the drug can safely reduce symptoms and bring about remission. The g…

This study is following about 4,000 people who have received a fecal microbiota transplant (FMT) to see how well it works over time and if it's safe. FMT involves putting healthy donor stool into a patient's gut to restore good bacteria. The study looks at conditions like severe …

This study looks at the safety and effectiveness of Velsipity tablets taken daily for up to 52 weeks by people with moderate to severe ulcerative colitis. About 553 participants will be followed in real-world medical settings. The goal is to see if the drug can help control sympt…

This study tests a new treatment plan for people with moderate to severe ulcerative colitis (UC). It combines two drugs: upadacitinib, which works quickly to reduce symptoms, followed by vedolizumab, which is safer for long-term use. The goal is to see if this sequence can help p…

This study tests a new drug called XmAb942 for people with moderate-to-severe ulcerative colitis, a condition that causes inflammation in the colon. First, healthy volunteers will help check the drug's safety. Then, about 270 people with ulcerative colitis will receive the drug o…

This study tests several new investigational drugs in 140 adults with moderate-to-severe Crohn's disease or ulcerative colitis. The main goals are to check safety and see if the drugs can improve symptoms and reduce gut inflammation seen on camera exams. Participants must have a …

This study looks at whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely take less of the drug ustekinumab without their disease coming back. About 115 participants will either stretch their injections from every 4 weeks to every 8 weeks,…

This study tests a new drug called HSK47388 in 150 adults with moderate-to-severe ulcerative colitis, a chronic bowel disease. Participants will receive either the drug or a placebo to see if it reduces symptoms like diarrhea and bleeding. The goal is to find a safer, more effect…

This study tests whether adding vitamin D3 supplements to standard treatment can lower inflammation in people with moderate ulcerative colitis. Sixty adults aged 20-40 will take either vitamin D3 (50,000 IU every two weeks) or a placebo for 12 weeks. Researchers will measure chan…

This study tests an experimental oral medication called MB-001 in 100 adults with moderate-to-severe ulcerative colitis. Participants take either MB-001 or a placebo daily for 12 weeks to see if it improves symptoms, reduces gut inflammation, and is safe. After that, everyone can…

This study tests whether a Mediterranean-style diet (called 'Nordiet') can improve gut bacteria, reduce inflammation, and ease symptoms in people with moderate Crohn's disease or ulcerative colitis. Researchers will also look at how exercise, sexual health, and quality of life re…

This study tests an experimental drug called OD-07656 in people with moderate to severe ulcerative colitis (UC). It also looks at whether giving OD-07656 first can make a follow-up treatment (vedolizumab) work better. About 57 adults with UC who haven't responded well to other th…

This study looks at people with ulcerative colitis who have already tried at least two advanced medications without success. Participants can choose to keep trying different drugs or have surgery to remove the colon, which can cure the disease but greatly affects daily life. Rese…

This study tests whether switching to a drug called guselkumab (Tremfya) can help people with inflammatory bowel disease (IBD) who did not get enough relief from ustekinumab. About 200 adults across Canada will take guselkumab for one year, and doctors will track their symptoms a…

This study tests whether taking selenium supplements can help people with moderate to severe ulcerative colitis respond better to advanced therapies like biologics. About 180 participants will receive either selenium or a placebo alongside their regular treatment. The goal is to …

This study is testing whether a smartphone app called SMART-IBD can help teenagers (ages 13-17) with inflammatory bowel disease (IBD) take their medications as prescribed and improve their self-management skills. The app includes daily symptom diaries, medication reminders, educa…

This study compares starting treatment with mirikizumab (a biologic drug) right away versus the usual step-up approach with azathioprine for people newly diagnosed with moderate-to-severe ulcerative colitis. About 300 adults will be randomly assigned to one of two groups and foll…

This study looks at whether teaching children and teens with inflammatory bowel disease (IBD) to eat fewer ultra-processed foods (like chips, soda, and fast food) can improve their health. About 120 participants will track their eating online and receive either a handout or a han…

This study tests whether adding the antihistamine desloratadine to standard treatment (mesalamine) can reduce inflammation and disease activity in people with mild to moderate ulcerative colitis. About 44 adults aged 18 to 65 who are already on mesalamine will take either deslora…

This study tests whether a ketogenic (low-carb, high-fat) or carnivore (meat-only) diet can improve quality of life and reduce symptoms in 160 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) or rheumatoid arthritis. Participants are randomly assigned to one…

This study looks at how gut bacteria change the way immune cells use energy, which may be linked to inflammatory bowel disease (IBD). Researchers will test 45 people—healthy adults and those with IBD—using blood, urine, and stool samples. Healthy volunteers will take a short cour…

This study follows 200 adults with Crohn's disease or ulcerative colitis who are prescribed Zymfentra as part of their normal care. Participants answer online surveys about their bowel symptoms over one year. The goal is to see if Zymfentra helps reduce symptoms and improve disea…

This study looks at whether using bowel ultrasound instead of colonoscopy or CT scans can reduce the carbon footprint of diagnosing and monitoring ulcerative colitis and Crohn's disease. Researchers will measure electricity, water, and waste from each method. 200 adults undergoin…

This study is a large registry that will follow 10,000 people with inflammatory bowel disease (Crohn's disease, ulcerative colitis, or indeterminate colitis) in Germany over many years. Researchers will collect real-world information on disease activity, treatment effectiveness, …

This study looks at whether people with ulcerative colitis (UC) who are in deep remission can safely reduce or stop their medication without the disease coming back. About 200 adults with UC will either continue their current therapy or de-escalate (decrease or stop) it, based on…

This study looks for tiny plastic particles (microplastics) in children with and without inflammatory bowel disease (IBD). Researchers will collect samples of gut tissue, stool, urine, and blood during routine medical procedures. The goal is to see if microplastics are present an…