ULCERATIVE COLITIS (UC)

This early-phase study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goals are to check safety and find the best dose, while also looking at how well it wo…

This study compares four different biologic treatments (infliximab, filgotinib, vedolizumab, and ustekinumab) as first-line therapies for people with moderate to severe ulcerative colitis. The goal is to see which treatment order works best to keep patients in remission and impro…

This study compares a new monitoring strategy using stool biomarkers against standard care for people with ulcerative colitis (UC) who are in remission. About 240 adults will be randomly assigned to either have their treatment adjusted based on stool test results or follow usual …

This study tests an experimental drug called SSGJ-627 in 288 adults with moderate to severe ulcerative colitis, a chronic bowel disease causing inflammation and symptoms like diarrhea and bleeding. The goal is to see if the drug can safely control the disease and improve symptoms…

This early-phase study tests a new drug, cizutamig, in 15 adults with moderate to severe ulcerative colitis who have not responded to other treatments. The main goal is to check if the drug is safe and tolerable. Researchers will monitor side effects throughout the study.

This study tests whether a daily synbiotic formula (SGR11) can improve symptoms and quality of life in 50 adults with mild to moderate ulcerative colitis, a type of inflammatory bowel disease. Participants take the formula for 8 weeks and complete questionnaires and stool tests. …

This study looks at whether people aged 60 and older with ulcerative colitis who are in long-term remission can safely stop taking thiopurines (a type of immune-suppressing drug) and stay on just mesalazine. The goal is to see if stopping thiopurines leads to more disease flare-u…

This study tests whether the antibiotic vancomycin can safely improve symptoms of ulcerative colitis in adults who also have a liver condition called primary sclerosing cholangitis. Fourteen participants will take vancomycin or a placebo for 4 weeks, with an option for 4 more wee…

This study tests whether an AI-enhanced virtual reality cognitive behavioral therapy program can reduce anxiety and improve quality of life in people with inflammatory bowel disease (IBD). About 76 adults with IBD and moderate-to-severe anxiety will use either the VR therapy or a…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 adults with long-term fatigue will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a large…

This study tests a new imaging method to see if two IBD drugs (adalimumab and risankizumab) actually reach the inflamed gut tissue. 30 adults with ulcerative colitis or Crohn's disease will receive a tiny dose of fluorescent-labeled drug before a routine colonoscopy. The goal is …

This study looks at how diet affects inflammation in people with Crohn's disease or ulcerative colitis. About 140 participants will either follow a Nordic test diet for six weeks or use a digital information tool. Researchers want to see if these approaches can lower inflammation…

This study will follow 4500 adults with Crohn's disease or ulcerative colitis to identify biological markers that predict how the disease will progress and whether complications arise. Researchers will analyze gut bacteria from stool and tissue samples to better understand the di…

This study will test whether an artificial intelligence (AI) system can help doctors identify inflammatory bowel disease (IBD) earlier. Researchers will analyze the medical records of 4500 people from a hospital in Taiwan, comparing the AI's suggestions to actual diagnoses. The g…

This study aims to learn how well people with Crohn's disease or ulcerative colitis follow a daily vitamin D supplement routine over 12 months. Researchers will also check if vitamin D improves quality of life and disease activity. About 150 adults will take 2,000 IU of vitamin D…

This study looks at why fecal transplants work for some gut diseases but not others. Researchers will follow 90 people with recurrent C. diff infection, ulcerative colitis, or metabolic syndrome to track how donor microbes settle in the gut. The goal is to find patterns that pred…

This study will check if a special ultrasound technique can accurately measure disease activity in people with moderate-to-severe ulcerative colitis. About 25 adults starting a new medication will be followed for 24 weeks. The goal is to see if ultrasound can replace the need for…

This study aims to see if data from smartwatches and smartphones can detect when inflammatory bowel disease (IBD) symptoms get worse. About 80 adults with Crohn's disease or ulcerative colitis will wear a smartwatch and use an app while shopping at Colruyt stores. Researchers wil…