Ulcerative colitis (UC)

This study compares four different sequences of biologic drugs (infliximab, filgotinib, ustekinumab, and vedolizumab) in 240 adults with moderate to severe ulcerative colitis. The goal is to see which order of treatments works best to achieve and maintain remission without steroi…

Researchers are running a phase 1 trial to find out how safe and tolerable ATTO-1091 is in healthy adults and in people with ulcerative colitis. The study also measures how long the drug stays in the body. About 96 participants will receive either ATTO-1091 or a placebo, visit th…

Researchers are testing whether nitazoxanide, an antiparasitic drug with anti-inflammatory properties, can help people with mild-to-moderate ulcerative colitis when added to their usual treatment. The trial enrolls adults aged 18 to 65 with active disease and stable therapy. Over…

This study tests whether oral vancomycin, an antibiotic, can help children aged 6-15 with inflammatory bowel disease (IBD), especially types linked to liver problems. About 140 kids will either get vancomycin plus standard care or standard care alone for up to a year. Researchers…

This trial compares two oral medications for active ulcerative colitis, a chronic inflammatory bowel disease causing diarrhea, bleeding, and pain. About 320 Chinese adults will be randomly assigned to take either etrasimod, a newer drug that blocks immune cells from entering the …

This clinical trial is testing an experimental oral medication called AC-101 in adults with moderately to severely active ulcerative colitis (UC), a chronic inflammatory bowel disease. The study aims to see if AC-101 can help achieve clinical remission—meaning fewer symptoms and …

This trial is testing an experimental oral drug called PTT-621 in adults aged 18-70 with moderate-to-severe ulcerative colitis who haven't responded well to standard treatments. Participants will take PTT-621 tablets for 12 weeks. The main goal is to see if the drug can improve t…

This early-stage trial is testing an experimental oral medication called Alpha-0261 in about 10 adults with moderate to severe ulcerative colitis. The main goal is to check the drug's safety and tolerability, while also looking at whether it can help reduce symptoms and lead to c…

This study tests whether a temporary higher dose of upadacitinib (45 mg daily) can bring ulcerative colitis back under control in adults whose disease flared up while on the standard 30 mg maintenance dose. Participants receive the higher dose for 8 to 16 weeks, then may step dow…

This study looks at how the oral medication etrasimod works for Chinese adults with active ulcerative colitis (UC) in real-world settings. About 500 participants will take etrasimod as part of their routine care and be followed for at least 52 weeks. Researchers will track change…

This study tests an experimental tablet called Hemay005 in 360 Chinese adults with moderate to severe ulcerative colitis, a chronic gut condition. Participants will receive either the drug or a placebo to see if it can bring about remission and improve symptoms over 12 weeks, wit…

This study looks at whether older adults (60+) with ulcerative colitis who are in long-term remission can safely stop taking thiopurines (azathioprine or 6-mercaptopurine) and rely only on high-dose mesalazine. Thiopurines carry increased risks of infection and cancer with age, s…

This early-stage study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goal is to check safety and find the best dose, while also looking at how well it work…

This pilot study tests a new synbiotic formula (SGR11) in 50 adults with mild-to-moderate ulcerative colitis, a type of inflammatory bowel disease. Participants take the supplement daily for 8 weeks. Researchers will check if symptoms improve and if the supplement is safe, using …

This study tests whether using stool biomarkers (fecal calprotectin and fecal immunochemical test) to guide treatment adjustments can prevent relapses in people with ulcerative colitis. About 240 adults in remission will be randomly assigned to either biomarker-guided therapy or …

This early-stage trial will test a new drug called cizutamig in 15 people with moderate to severe ulcerative colitis who haven't improved with other treatments. The main goal is to check if the drug is safe and tolerable. It is not yet recruiting and will be conducted at a single…

This pilot study tests whether the antibiotic vancomycin can safely treat active ulcerative colitis in adults who also have primary sclerosing cholangitis, a liver condition. Fourteen participants will take vancomycin or a placebo for 4 weeks, with an optional 4-week extension. T…

This study tests whether ratios of routine blood markers—like C-reactive protein-to-albumin and neutrophil-to-lymphocyte—can accurately tell if inflammatory bowel disease (IBD) is active or in remission. Adults with Crohn's disease or ulcerative colitis will have blood tests and …

This study tests whether combining two stool tests—fecal immunochemical test (FIT) and fecal calprotectin (FC)—can accurately detect precancerous or cancerous changes in people with long-standing ulcerative colitis. Participants will provide stool samples and then undergo a speci…

This study looks at whether a substance in urine, called PGE-MUM, can show if ulcerative colitis is active or in remission. Researchers will collect urine and blood samples from 114 adults with confirmed ulcerative colitis and compare the results with colonoscopy findings. If suc…

This trial tests whether applying 5-ASA (mesalamine) directly to the ileal pouch after surgery for ulcerative colitis can prevent pouchitis—a painful inflammation that affects more than half of patients. Adults with UC who are scheduled for pouch surgery are randomly assigned to …

This trial tests whether a personalized 6-month exercise program can reduce persistent fatigue in people with inflammatory bowel disease (IBD) who are in remission. Researchers will randomly assign 120 participants to either the exercise program or usual care. Fatigue levels are …

This study tests whether a 10-session virtual group psychotherapy program can help people with inflammatory bowel disease (IBD) who also have anxiety or depression. The therapy is adapted from a standard manual called Mind Over Mood and includes education on the brain-gut connect…

This study tests two online pain education programs for adults with Crohn's disease or ulcerative colitis who have chronic pain. Participants will complete a 2-hour online session and report their pain and quality of life weekly for 8 weeks. The goal is to see if these programs a…

This study tests whether a short liquid diet followed by a low-sulfur eating plan is safe and helpful for people with mild to moderate ulcerative colitis. Researchers will check if this approach improves gut health, lowers inflammation, and eases symptoms. They will also use brea…

This study tests whether an AI-enhanced virtual reality cognitive behavioral therapy (VR/AI CBT) program can reduce anxiety and improve quality of life in people with inflammatory bowel disease (IBD). Seventy-six adults with IBD and moderate-to-severe anxiety will be randomly ass…

This study tests whether modafinil, a drug used for narcolepsy, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 participants will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a larger trial is possible, bu…

Researchers are testing whether blocking three inflammation pathways at once (TL1A, IL-23, and α4β7) calms inflamed intestinal tissue more effectively than blocking each pathway alone. The study enrolls 30 people: 10 with ulcerative colitis, 10 with Crohn's disease, and 10 withou…

Researchers are testing a visual sampling capsule that collects fluid from different parts of the intestine without surgery. They will use it in 250 people, including those with active or remission Crohn's disease or ulcerative colitis, plus healthy volunteers. By analyzing the m…

This study explores whether changes in heart rate, sleep, and activity measured by a person's own smartwatch can predict flare-ups in inflammatory bowel disease (IBD). Six hundred adults with Crohn's disease or ulcerative colitis who already own a compatible device will participa…

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study will test whether an artificial intelligence (AI) system can help doctors identify inflammatory bowel disease (IBD) earlier and more accurately. Researchers will analyze medical records from 4,500 patients to see how well the AI's suggestions match actual diagnoses. Th…

This study will give fecal transplants to 90 people with recurrent C. difficile infection, ulcerative colitis, or metabolic syndrome. Researchers will use advanced tests on stool and tissue samples to track how donor bacteria settle in the gut and interact with the host. The goal…

This pilot study will test whether a modified ultrasound technique can accurately measure disease activity in people with moderate-to-severe ulcerative colitis. Researchers will compare ultrasound results with standard colonoscopy findings in 25 patients starting a new treatment.…

This study tests whether fluorescent dyes attached to two IBD drugs (adalimumab and risankizumab) can show where the drugs go in the gut. 30 adults with ulcerative colitis or Crohn's disease will receive a low dose of the labelled drugs, then undergo a special camera procedure 2-…

This study looks at whether taking a daily vitamin D supplement (2000 IU) for 12 months can improve the health and quality of life of people with Crohn's disease or ulcerative colitis. Researchers will track how well participants stick to the supplement and measure their vitamin …

This observational study will follow 4500 adults with Crohn's disease or ulcerative colitis to identify biological markers—such as gut bacteria patterns—that predict disease progression and complications. Researchers will collect blood, stool, saliva, and tissue samples during ro…

This study tests whether data from a wearable device and grocery loyalty cards can help detect disease flares in people with Crohn's disease or ulcerative colitis. Eighty adults will wear a smartwatch and use a store card to track their health and food purchases. The goal is to d…