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Can a special diet tame ulcerative colitis? breath tests may tell

NCT ID NCT07640659

Symptom relief Sponsor: University of British Columbia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a short liquid diet followed by a low-sulfur eating plan is safe and helpful for people with mild to moderate ulcerative colitis. Researchers will check if this approach improves gut health, lowers inflammation, and eases symptoms. They will also use breath samples to track gut bacteria activity in a simple, non-invasive way.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Elemental liquid diet and low-sulfur eating plan
What this could lead to
If successful, this could provide a non-invasive way to monitor gut health and a dietary approach to manage ulcerative colitis symptoms.
What could go wrong
This is a small, early-stage study with only 45 participants, so results may not apply to everyone. The diet may be hard to follow, and it's not yet proven to work.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 19-70 years. =Diagnosis of mild-to-moderate ulcerative colitis, defined by a partial Mayo score (pMayo) of 2-7. * Evidence of active inflammation at enrollment, defined as: * C-reactive protein (CRP) \> 5 mg/L; or * Fecal calprotectin (FCP) \> 200 µg/g. * Receiving stable medical therapy for ulcerative colitis for at least 8 weeks prior to enrollment. * No corticosteroid use at the time of recruitment. * Under consideration by the treating physician for treatment escalation or biologic switch due to inadequate response to current therapy. Exclusion Criteria: * Partial Mayo score (pMayo) \> 7. * Pregnant or breastfeeding. * Body mass index (BMI) \< 18 kg/m². * History of an eating disorder. * Severe psychiatric disorder. * Severe medical conditions, including: * Active cancer; * Significant cardiovascular disease; * Diabetes mellitus; or * Severe food allergies. * Known allergy or intolerance to corn, dextrose, or maltodextrin. * Antibiotic use within 3 months prior to enrollment. * Probiotic use within 3 months prior to enrollment. * Use of herbal anti-inflammatory supplements during the study period, including but not limited to: * Serrapeptidase; * Curcumin; * Boswellia; or * Bromelain. * History of major gastrointestinal surgery, including: * Ostomy; * Total colectomy; or * Short bowel syndrome. * Inability or unwillingness to comply with study procedures, including anticipated travel or other commitments that may interfere with participation.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ulcerative colitis (UC)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of British Columbia-Okanagan

    Kelowna, British Columbia, V1V 1V7, Canada

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