New pill could clear psoriasis in teens

NCT ID NCT06979453

Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Sep 04, 2026 · Updated 7 times

Summary

This study tests a daily pill called deucravacitinib in teenagers aged 12 to 18 with moderate to severe plaque psoriasis. About 366 participants will receive either the drug or a placebo. The main goals are to see if the drug improves skin clearance by at least 75% and reduces overall severity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Deucravacitinib
What this could lead to: If successful, this could provide a new oral treatment option for teenagers with moderate to severe plaque psoriasis, helping clear skin and reduce itching.
What could go wrong: This is a phase 3 trial, but results may not apply to all teens. Side effects are possible, and the drug may not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 366 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Aug 2034

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Participants must have stable plaque psoriasis for 6 months or more prior to Screening. * Participants must have moderate to severe psoriasis defined by:. i) Psoriasis Area and Severity Index (PASI) ≥ 12, at screening visit and Day 1. ii) Static Physician's Global Assessment (sPGA) ≥ 3, at screening visit and Day 1. iii) Body Surface Area (BSA) ≥ 10% involvement, at screening visit and Day 1. \- A female (as assigned at birth) participant is eligible to participate if she is not pregnant or breastfeeding, and at least 1 of the following conditions applies:. i) Is not an individual of childbearing potential (IOCBP). ii) Is an IOCBP and using a contraceptive method that is highly effective (with a failure rate of \< 1% per year) during the study intervention period and for at least 3 days after discontinuation of the study intervention and agrees not to donate eggs (ova, oocytes) for the purpose of reproduction for the same period. Exclusion Criteria * Participants must not weigh \< 30.0 kg at Screening and Day 1. * Participants must not have non-plaque psoriasis (ie, guttate, inverse, pustular, erythrodermic, or drug-induced psoriasis) or any skin condition other than plaque psoriasis that could interfere with assessments of treatment effect at Screening or Day 1. * Participants must not have a history of serious bacterial, fungal, or viral infection requiring hospitalization and intravenous (IV) antimicrobial treatment within 60 days prior to Day 1. * Participants must not have any untreated bacterial infection within 60 days prior to Day 1. * Participants must not have any ongoing evidence of chronic bacterial infection (eg, chronic pyelonephritis, chronic osteomyelitis, chronic bronchiectasis). * Participants must not have herpes simplex/zoster, active tuberculosis (TB), hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV) infection-related exclusions. * Participants must not have received live vaccines or BCG within 60 days prior to Day 1 or plans to receive a live vaccine during the study, or within 60 days after completing study intervention. * Participants must not have had any prior exposure to deucravacitinib. * Participants must not have received any medication that is specifically prohibited. * Participants must not have a laboratory finding that is exclusionary. * Participants must not have any major illness/condition or evidence of an unstable clinical condition (eg, renal, hepatic, hematologic, gastrointestinal, endocrine, pulmonary, psychiatric, neurologic, immunologic, or local active infection/infectious illness) that, in the investigator's judgment or after consultation with the Sponsor's Medical Monitor, will substantially increase the risk to the participant if he or she participates in the study. * Participants must not have cancer or history of cancer (solid organ or hematologic including myelodysplastic syndrome) or lymphoproliferative disease within the previous 5 years. * Other protocol-defined Inclusion/Exclusion criteria apply.

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Conditions

The condition(s) this trial relates to.

exanthem Pruritus psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Plaque psoriasis

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

125 sites in 16 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

"DERMED" Centrum Medyczne Sp. z o.o.
RECRUITING

Lodz, 90-265, Poland
Advanced Medical Research, PC.
RECRUITING

Sandy Springs, Georgia, 30328, United States
Alberta Dermasurgery Centre
RECRUITING

Edmonton, Alberta, T6G 1C3, Canada
Apex Clinical Research Center
RECRUITING

Lorain, Ohio, 44053, United States
Apex Clinical Research Center
RECRUITING

Mayfield Heights, Ohio, 44124, United States
Apex Clinical Research Center - Canton
RECRUITING

Canton, Ohio, 44716, United States
Arké SMO S.A de C.V
RECRUITING

Veracruz, 91910, Mexico
AvantDerm
RECRUITING

Toronto, Ontario, M5A 3R6, Canada
BAG Drs. Med. Quist PartG
RECRUITING

Mainz, Rhineland-Palatinate, 55128, Germany
Beijing Children's hospital, Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 100045, China
C.S. Mott Clinical Research Center (CRC)
RECRUITING

Detroit, Michigan, 48201, United States
CHUS - Hospital Clinico Universitario
RECRUITING

Santiago de Compostela, 15706, Spain
CONEXA Investigacion Clinica S.A.
RECRUITING

Buenos Aires, 1012, Argentina
Center For Dermatology Clinical Research, Inc.
RECRUITING

Fremont, California, 94538, United States
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
RECRUITING

Liège, 4000, Belgium
Centro de Investigaciones Médicas Tucuman
RECRUITING

SAN M. de Tucuman, Tucumán Province, T4000AXL, Argentina
Centrul de Medicina de Familie
RECRUITING

Iași, 700556, Romania
Chang Gung Medical Foundation-Linkou Branch
RECRUITING

Taoyuan, 333, Taiwan
Chang Gung Memorial Hospital at Kaohsiung
RECRUITING

Kaohsiung Niao Sung Dist, Kaohsiung, 83301, Taiwan
Charité - Universitaetsmedizin Berlin - Campus Bejnamin Franklin
RECRUITING

Berlin, 10117, Germany
Clinexpert Kft.
RECRUITING

Budapest, Pest County, 1033, Hungary
Cliniques universitaires Saint-Luc
RECRUITING

Brussels, Bruxelles-Capitale, Région de, 1200, Belgium
Dawes Fretzin Clinical Research Group, LLC
RECRUITING

Indianapolis, Indiana, 46250, United States
Debreceni Egyetem Klinikai Kozpont
RECRUITING

Debrecen, 4032, Hungary
DermEffects
RECRUITING

London, Ontario, N6H 5L5, Canada
Derma Internacional
RECRUITING

Buenos Aires, 1426, Argentina
Dermatology Affiliates Research Institute
RECRUITING

Atlanta, Georgia, 30305, United States
Dermatology Research Associates
RECRUITING

Los Angeles, California, 90045, United States
Dermatology and Skin Cancer Center
RECRUITING

Lee's Summit, Missouri, 64064, United States
Dermatology and Skin Cancer Specialists, LLC
RECRUITING

Rockville, Maryland, 20850, United States
ETYKA Osrodek Badan Klinicznych
RECRUITING

Olsztyn, 10-117, Poland
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
RECRUITING

Roma, 00168, Italy
Frontier Derm Partners
RECRUITING

Mill Creek, Washington, 98012, United States
FutureMeds - Targowek
RECRUITING

Warsaw, Masovian Voivodeship, 03-291, Poland
GCM Medical Group, PSC - Hato Rey Site
RECRUITING

San Juan, 00917, Puerto Rico
Golden State Dermatology - Walnut Creek - Ygnacio Valley Road
RECRUITING

Walnut Creek, California, 94598, United States
Grupo Dermatológico y Estético Pedro Jaén S.A
RECRUITING

Madrid, 28002, Spain
Guangdong Province Dermatology Hospital
RECRUITING

Guangzhou, Guangdong, 510018, China
Henry Ford Medical Center
RECRUITING

Detroit, Michigan, 48202-3141, United States
Hospital Italiano de Buenos Aires
RECRUITING

Buenos Aires, 1181, Argentina
Hospital Moinhos de Vento
RECRUITING

Porto Alegre, Rio Grande do Sul, 90560-032, Brazil
Hospital Sant Joan de Déu
RECRUITING

Esplugues de Llobregat, Barcelona [Barcelona], 08950, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP) - HCFMRP
RECRUITING

Ribeirão Preto, São Paulo, 14051-140, Brazil
Hospital de Niños Dr. Ricardo Gutiérrez
RECRUITING

Buenos Aires, 1425, Argentina
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, Catalunya [Cataluña], 08041, Spain
Hunan Children's Hospital
RECRUITING

Changsha, Hunan, 410007, China
Instituto Dermatologico de Jalisco
RECRUITING

Zapopan, Jalisco, 45190, Mexico
Instituto de Neumonologia Y Dermatologia
RECRUITING

Ciudad Autonoma de Buenos Aires, Buenos Aires, 1425, Argentina
JDR Dermatology Research
RECRUITING

Las Vegas, Nevada, 89148, United States
Kaohsiung Veterans General Hospital
RECRUITING

Kaohsiung City, 81362, Taiwan
Kentucky Advanced Medical Research LLC
RECRUITING

Murray, Kentucky, 42071, United States
Klinika Ambroziak Dermatologia
RECRUITING

Warsaw, 02-953, Poland
Kuchnir Dermatology & Dermatologic Surgery
RECRUITING

Milford, Massachusetts, 01757, United States
Life Clinical Trials
RECRUITING

Margate, Florida, 33063, United States
Local Institution - 0008
NOT_YET_RECRUITING

Caguas, 00725, Puerto Rico
Local Institution - 0021
NOT_YET_RECRUITING

Clearwater, Florida, 33756, United States
Local Institution - 0025
NOT_YET_RECRUITING

Fountain Valley, California, 92708, United States
Local Institution - 0041
NOT_YET_RECRUITING

Birmingham, Alabama, 35243, United States
Local Institution - 0045
NOT_YET_RECRUITING

Norfolk, Virginia, 23502, United States
Local Institution - 0053
ACTIVE_NOT_RECRUITING

Phoenix, Arizona, 85006, United States
Local Institution - 0077
NOT_YET_RECRUITING

Sacramento, California, 95814, United States
Local Institution - 0124
NOT_YET_RECRUITING

Medellín, Antioquia, 50021, Colombia
Local Institution - 0125
NOT_YET_RECRUITING

Bogota, Cundinamarca, 111 411, Colombia
Local Institution - 0137
NOT_YET_RECRUITING

Salvador, Estado de Bahia, 41820-020, Brazil
Local Institution - 0142
NOT_YET_RECRUITING

Montreal, Quebec, H3T 1C5, Canada
Local Institution - 0155
NOT_YET_RECRUITING

Monterrey, Nuevo León, 64718, Mexico
Local Institution - 0164
NOT_YET_RECRUITING

Winnipeg, Manitoba, R3C 0N2, Canada
Local Institution - 0166
NOT_YET_RECRUITING

The Bronx, New York, 10467, United States
Local Institution - 0167
NOT_YET_RECRUITING

Barranquilla, Atlántico, 080002, Colombia
Local Institution - 0170
NOT_YET_RECRUITING

São Paulo, 05403-000, Brazil
Local Institution - 0174
WITHDRAWN

Bucharest, Bucharest, 020125, Romania
Local Institution - 0177
WITHDRAWN

Lublin, Lublin Voivodeship, 20-573, Poland
Local Institution - 0182
NOT_YET_RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Local Institution - 0187
NOT_YET_RECRUITING

Rome, Lazio, 00133, Italy
Local Institution - 0202
NOT_YET_RECRUITING

Metairie, Louisiana, 70001, United States
Local Institution - 0205
NOT_YET_RECRUITING

New York, New York, 10075, United States
Local Institution - 0210
WITHDRAWN

Brussels, Bruxelles-Capitale, Région de, 1200, Belgium
Local Institution - 0213
WITHDRAWN

Bucharest, Bucharest, 30463, Romania
Local Institution - 0225
NOT_YET_RECRUITING

Medellín, Antioquia, 050012, Colombia
Local Institution - 0228
NOT_YET_RECRUITING

Chengdu, Sichuan, 610091, China
Local Institution - 0233
NOT_YET_RECRUITING

Columbia, Missouri, 65201, United States
Local Institution - 0234
COMPLETED

Hickory, North Carolina, 28602, United States
Local Institution - 0240
NOT_YET_RECRUITING

Toronto, Ontario, M5G 1X8, Canada
Local Institution - 0248
COMPLETED

Nashville, Tennessee, 37205, United States
Local Institution - 0253
NOT_YET_RECRUITING

Mexico City, Mexico City, 06720, Mexico
Local Institution - 0254
NOT_YET_RECRUITING

Bayamón, 00960, Puerto Rico
Local Institution - 0257
NOT_YET_RECRUITING

Mérida, 97070, Mexico
Local Institution - 0258
NOT_YET_RECRUITING

Toluca, 50010, Mexico
Local Institution - 0259
NOT_YET_RECRUITING

Chihuahua City, 31217, Mexico
Local Institution - 0261
NOT_YET_RECRUITING

Birmingham, Alabama, 35203, United States
Local Institution - 0264
NOT_YET_RECRUITING

Spokane, Washington, 99204, United States
Local Institution - 0271
NOT_YET_RECRUITING

Ammon, Idaho, 83406, United States
Local Institution - 0273
NOT_YET_RECRUITING

Brooklyn, New York, 11203, United States
Local Institution - 0278
NOT_YET_RECRUITING

Columbia, Missouri, 65212, United States
Local Institution - 0280
NOT_YET_RECRUITING

Southlake, Texas, 76092, United States
Local Institution - 0281
NOT_YET_RECRUITING

Robbinsville, New Jersey, 08691, United States
Local Institution - 0282
NOT_YET_RECRUITING

Gdansk, Pomeranian Voivodeship, 80-546, Poland
Local Institution - 0283
NOT_YET_RECRUITING

Clifton, New Jersey, 07013, United States
Local Institution - 0284
NOT_YET_RECRUITING

Campinas, São Paulo, 13086-888, Brazil
Local Institution - 0285
NOT_YET_RECRUITING

Bucharest, Bucharest, 030463, Romania
Local Institution - 0286
NOT_YET_RECRUITING

Cluj-Napoca, 400006, Romania
Lotus-Med Tunari
RECRUITING

Bucharest, Bucharest, 020528, Romania
MOORE Clinical Research, Inc. d/b/a TrueBlue Clinical Research
RECRUITING

Tampa, Florida, 33607, United States
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
New Derm Clinical SRL
RECRUITING

Timișoara, 300757, Romania
Northridge Clinical Trials
RECRUITING

Northridge, California, 91325, United States
ObjectiveHealth - Goodlettsville Dermatology Research
RECRUITING

Goodlettsville, Tennessee, 37072, United States
Paddington Testing Company
RECRUITING

Philadelphia, Pennsylvania, 19103, United States
Paradigm Clinical Research, LLC
RECRUITING

Wheat Ridge, Colorado, 80033, United States
Peking University Third Hospital
RECRUITING

Beijing, Beijing Municipality, 100091, China
People's Hospital of Henan Province
RECRUITING

Zhengzhou, Henan, 450003, China
Policlinica Providența
RECRUITING

Iași, 700259, Romania
Psoriahue
RECRUITING

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1425DKG, Argentina
Royalderm Agnieszka Nawrocka
RECRUITING

Warsaw, 02-962, Poland
SPECDERM Poznanska sp.j.
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-375, Poland
Shandong Provincial Dermatology Hospital and Shandong Institute of Dermatology and Venereology
RECRUITING

Jinan, Shandong, 250022, China
Shanghai Skin Disease Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200443, China
Skin Research of South Florida
RECRUITING

Miami, Florida, 33173, United States
Skincare Studio
RECRUITING

St. John's, Newfoundland and Labrador, A1E 1V4, Canada
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
RECRUITING

Szeged, Csongrád megye, 6720, Hungary
Texas Dermatology and Laser Specialists
RECRUITING

San Antonio, Texas, 78218, United States
The Affiliated Hospital of Hebei University of Engineering
RECRUITING

Handan, Hebei, 56029, China
The Centre for Dermatology
RECRUITING

Richmond Hill, Ontario, L4B 1A5, Canada
The First People's Hospital of Hangzhou
RECRUITING

Hangzhou, Zhejiang, 310006, China
The University of Hong Kong-Shenzhen Hospital
RECRUITING

Shenzhen, Guangdong, 518053, China
USF Health
RECRUITING

Tampa, Florida, 33612, United States
UZ Gent
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium
Universitaetsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, 01307, Germany
Universitaetsklinikum Erlangen
RECRUITING

Erlangen, 91054, Germany
Universitätsklinikum Münster
RECRUITING

Münster, North Rhine-Westphalia, 48149, Germany
Wellness Clinical Research
RECRUITING

Miami Lakes, Florida, 33016, United States

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