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Can a beam of light banish toenail fungus?

NCT ID NCT07756671

Disease control Sponsor: The University of Texas Health Science Center, Houston Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 11, 2026 · Last updated Sep 04, 2026 · Updated 3 times

Summary

This trial tests whether photodynamic therapy (PDT) can clear toenail fungus. People with a confirmed fungal nail infection will have a special gel applied to the affected nail, then exposed to red light. The study will check if the nail looks healthy and if the fungus is gone at several follow-up points over a year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Photodynamic therapy using aminolevulinic acid (ALA) 10% gel and red light, with urea pretreatment
What this could lead to
If successful, this could offer a non-drug, light-based option for clearing toenail fungus, potentially helping people who can't take oral antifungals.
What could go wrong
This is a very small early-phase trial (5 people), so results may not apply broadly. The treatment may not fully clear the infection, and side effects like skin reactions are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 5 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical and mycological diagnosis \[by potassium hydroxide (KOH) stain\] of onychomycosis Exclusion Criteria: * Known or suspected allergies or sensitivities to any components of any of the study drugs * Patients with coagulation disorders * Known or suspected claustrophobia * Pregnancy during the treatment period * Medically unable to consent * Employees of the clinics * Prisoners

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Conditions

The condition(s) this trial relates to.

fungal infection of the toenail tinea unguium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Onychomycosis of toenail

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Arlington Center for Dermatology

    RECRUITING

    Arlington, Texas, 76011, United States

  • Houston Skin

    NOT_YET_RECRUITING

    Houston, Texas, 77004, United States

  • Houston Skin

    NOT_YET_RECRUITING

    Webster, Texas, 77598, United States

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