Promising cream may help kids with vitiligo regain skin color

NCT ID NCT06548360

Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 6 times

Summary

This study tests a cream called ruxolitinib in 180 children with nonsegmental vitiligo, a condition that causes white patches on the skin. The goal is to see if the cream can safely bring back color, especially on the face. Participants will apply the cream daily for several months, and doctors will measure improvement using a special scoring system.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 180 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 11 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical diagnosis of nonsegmental vitiligo with depigmented area including ≥ 0.5% BSA on the face, ≥ 0.5 F-VASI, ≥ 2% BSA on nonfacial areas, ≥ 2 T-VASI. * Total body vitiligo area does not exceed 10% BSA. * Pigmented hair within some of the areas of vitiligo on the face. * Must agree to discontinue all agents used to treat vitiligo from screening through the final safety follow-up visit. * For sexually active participants (except participants who are prepubescent) willingness to avoid pregnancy or fathering a child from screening through 30 days after the last application of study cream. Exclusion Criteria: * Diagnosis of other forms of vitiligo (eg, segmental). * Other differential diagnosis of vitiligo or other skin depigmentation disorders (eg, piebaldism, pityriasis alba, leprosy, postinflammatory hypopigmentation, progressive macule hypomelanosis, nevus anemicus, chemical leukoderma, and tinea versicolor). * Any other skin disease that, in the opinion of the investigator, would interfere with the study drug application or study assessments. * Prior or current use of depigmentation treatments (eg, monobenzone). * Any serious illness or medical, physical, or psychiatric condition(s) that, in the investigator's opinion, would interfere with full participation in the study, including application of study cream and attending required study visits; pose a significant risk to the participant; or interfere with interpretation of study data. * Use of protocol-defined treatments within the indicated washout period before baseline. * History of treatment failure with any systemic or topical JAK inhibitor (eg, ruxolitinib, tofacitinib, baricitinib, abrocitinib, and upadacitinib) for vitiligo or any other inflammatory condition. * Protocol-defined clinically significant abnormal laboratory values at screening. * Pregnant or lactating participants or those considering pregnancy during the period of their study participation. * In the opinion of the investigator, unable or unlikely to comply with the application schedule and study evaluations. * Living with anyone participating in any current Incyte-sponsored ruxolitinib cream study. * Employees of the sponsor or investigator or are otherwise dependents of them. * Known allergy or reaction to any component of the study cream formulation. Other protocol-defined Inclusion/Exclusion Criteria may apply.

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Conditions

The condition(s) this trial relates to.

generalized vitiligo vitiligo

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nonsegmental vitiligo

How to take part

Only the study team decides who joins. These are the ways to reach them.

The study's own enquiry address

This study publishes an address for enquiries. See it below .
The places running it

88 sites in 2 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

3A Research Llc West Location
RECRUITING

El Paso, Texas, 79902, United States
Acrc Trials
RECRUITING

Grapevine, Texas, 07605, United States
Advanced Medical Research Pc
RECRUITING

Sandy Springs, Georgia, 30328, United States
Affiliated Dermatology
COMPLETED

Scottsdale, Arizona, 85255, United States
Alberta Dermasurgery Centre
RECRUITING

Edmonton, Alberta, T6G 1C3, Canada
Alberta Health Services (Ahs) - Alberta Children'S Hospital (Ach)
RECRUITING

Calgary, Alberta, T3B 6A8, Canada
Axon Clinical Research
RECRUITING

Inglewood, California, 90301, United States
Banner - University Medicine Multispecialty Services Clinic
RECRUITING

Tucson, Arizona, 85718, United States
Boeson Research
RECRUITING

Missoula, Montana, 59804, United States
Burke Pharmaceutical Research
COMPLETED

Hot Springs, Arkansas, 71913, United States
Centre Hospitalier Universitaire de Quebec - Centre Hospitalier de L'Universite Laval (Chul)
RECRUITING

Québec, Quebec, G1V 4G2, Canada
Centre de Recherche Saint-Louis
RECRUITING

Québec, Quebec, G1W 4R4, Canada
Centre de Recherche St-Louis
RECRUITING

Montreal, Quebec, H1Y 3L1, Canada
Children'S Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Cleaver Medical Group
RECRUITING

Cumming, Georgia, 30040, United States
Coal Harbour Rejuvenation Dermatology, Inc.
RECRUITING

Vancouver, British Columbia, V6C 0C3, Canada
Columbia Dermatology
RECRUITING

Columbia, South Carolina, 29212, United States
Cosmetic Dermatology on Bloor
RECRUITING

Toronto, Ontario, M5S 3B4, Canada
Dar Clinical Research Inc
RECRUITING

Ottawa, Ontario, K2T 0N7, Canada
Dell Children'S Medical Group
RECRUITING

Austin, Texas, 78723, United States
Dermatology Associates Pc
RECRUITING

Rockville, Maryland, 20850, United States
Dermatology Research Associates
RECRUITING

Los Angeles, California, 90045, United States
Dermatology Research Institute
RECRUITING

Calgary, Alberta, T2J 7E1, Canada
Dermatology Specialists of Spokane
RECRUITING

Spokane, Washington, 99202, United States
Dermatology and Cosmetic Center
RECRUITING

Flint, Michigan, 48507, United States
Dermcare Clinic
NOT_YET_RECRUITING

Mississauga, Ontario, L4W 0C2, Canada
Dh Tamarac Research Center Etna Medical Center Emc
RECRUITING

Tamarac, Florida, 33321, United States
Empire Clinical Research
RECRUITING

Pomona, California, 91767, United States
Encore Medical Research, Llc Boynton Beach
RECRUITING

Boynton Beach, Florida, 33436, United States
Equity Medical, Llc
COMPLETED

New York, New York, 10023, United States
Forefront Dermatology
NOT_YET_RECRUITING

Libertyville, Illinois, 60048, United States
Frontier Dermatology
RECRUITING

Mill Creek, Washington, 98012, United States
Golden State Dermatology
NOT_YET_RECRUITING

Walnut Creek, California, 94598, United States
Illinois Dermatology Institute the Chicago Loop
RECRUITING

Chicago, Illinois, 60602, United States
Indiana University School of Medicine
RECRUITING

Indianapolis, Indiana, 46202, United States
International Clinical Research Tennessee Llc
COMPLETED

Murfreesboro, Tennessee, 37130, United States
Jordan Valley Dermatology Center
RECRUITING

South Jordan, Utah, 84095, United States
Kirk Barber Research
RECRUITING

Calgary, Alberta, T2G 1B1, Canada
La Universal Research Center, Inc
RECRUITING

Los Angeles, California, 90057, United States
Laser Rejuvenation Clinics Edmonton D.T. Inc
RECRUITING

Edmonton, Alberta, T5J 3S9, Canada
Maritime Dermatology
RECRUITING

Halifax, Nova Scotia, B3K5R3, Canada
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Medisearch Clinical Trials
COMPLETED

Saint Joseph, Missouri, 64506, United States
Metro Boston Clinical Partners
COMPLETED

Brighton, Massachusetts, 02135-3511, United States
Mi Skin Center, Pllc
RECRUITING

Northville, Michigan, 48167, United States
Michigan Dermatology Institute
RECRUITING

Waterford, Michigan, 48328, United States
Mount Sinai Doctors
RECRUITING

New York, New York, 10028-3135, United States
Nicklaus Children'S Hospital
RECRUITING

Miami, Florida, 33155, United States
Northshore University Healthsystem
RECRUITING

Skokie, Illinois, 60077, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Omni Dermatology
RECRUITING

Phoenix, Arizona, 85037, United States
Paradigm Clinical Research Centers, Inc.
RECRUITING

Wheat Ridge, Colorado, 80033, United States
Pediatric Skin Research Llc
RECRUITING

Miami, Florida, 33146, United States
Peninsula Research Associates Pra
COMPLETED

Rolling Hills Estates, California, 90274-7604, United States
Phoenix Children'S Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Premier Dermatology Clinical Trials Institute At Northwest Arkansas
RECRUITING

Fayetteville, Arkansas, 72703, United States
Rady Children'S Hospital-San Diego
RECRUITING

San Diego, California, 92123, United States
Red River Research Partners
RECRUITING

Fargo, North Dakota, 58103, United States
Reveal Research Institute
RECRUITING

Frisco, Texas, 75033, United States
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States
Sadick Dermatology Sadick Research Group
COMPLETED

New York, New York, 10075, United States
Saguaro Dermatology
RECRUITING

Phoenix, Arizona, 85008, United States
Saskatoon Dermatology Centre
RECRUITING

Saskatoon, Saskatchewan, S7T 0G3, Canada
Seattle Children'S Hospital
RECRUITING

Seattle, Washington, 98105, United States
Skin Care Research, Llc
RECRUITING

Boca Raton, Florida, 33486, United States
Skin Care Research, Llc
RECRUITING

Hollywood, Florida, 33201, United States
Skin Physicians
NOT_YET_RECRUITING

Edmonton, Alberta, T6W 4V4, Canada
Skin Search of Rochester
RECRUITING

Rochester, New York, 14623, United States
Skin Specialists Pc the Advanced Skin Research Center
RECRUITING

Omaha, Nebraska, 68144, United States
Skin and Hair Center
RECRUITING

Overland Park, Kansas, 66213, United States
Skincare Studio Dermatology Centre
RECRUITING

St. John's, A1E 1V4, Canada
Solutions Through Advanced Research, Inc
RECRUITING

Jacksonville, Florida, 32256, United States
Stanford School of Medicine
RECRUITING

Palo Alto, California, 94304, United States
Stryde Research
RECRUITING

Southlake, Texas, 76092, United States
Suny Downstate Medical Center
RECRUITING

Brooklyn, New York, 11203, United States
Texas Dermatology and Laser Specialists
RECRUITING

San Antonio, Texas, 78218, United States
The Dermatology Specialists Greenwich
RECRUITING

New York, New York, 10012, United States
The University of New Mexico Unm Health Sciences Center Hsc
RECRUITING

Albuquerque, New Mexico, 87102, United States
The University of Texas Health Science Center At Houston
RECRUITING

Bellaire, Texas, 77401, United States
Treasure Valley Medical Research
RECRUITING

Boise, Idaho, 83706, United States
Tulane University Health Sciences Center
RECRUITING

New Orleans, Louisiana, 70112, United States
Universite de Montreal - Centre Hospitalier Universitaire (Chu) Sainte-Justine - Centre de Recherche
RECRUITING

Montreal, Quebec, H3T 1C5, Canada
University of Alabama At Birmingham-School of Medicine
RECRUITING

Birmingham, Alabama, 35233, United States
University of California Irvine
RECRUITING

Irvine, California, 92697, United States
University of Missouri Kansas City
NOT_YET_RECRUITING

Kansas City, Missouri, 64108, United States
University of Toronto - the Hospital For Sick Children (Sickkids)
RECRUITING

Toronto, Ontario, M5G1X8, Canada
University of Utah Midvalley Dermatology
RECRUITING

Murray, Utah, 84107, United States
University of Wisconsin School of Medicine
RECRUITING

Madison, Wisconsin, 53715, United States
Us Dermatology Partners Longview
COMPLETED

Longview, Texas, 75601, United States
Usf Health Morsani Center For Advanced Healthcare
RECRUITING

Tampa, Florida, 33612, United States
Vitality Clinical Research Llc
RECRUITING

Woodbury, New York, 11797, United States
Vitiligo & Pigmentation Institute of Southern California
RECRUITING

Los Angeles, California, 90036-5609, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Wellskin Dermatology & Aesthetics
COMPLETED

Bowling Green, Kentucky, 42104, United States
Winnipeg Clinic
RECRUITING

Winnipeg, Manitoba, R3C 1T6, Canada
Wright State Physicians Health Center
RECRUITING

Beavercreek, Ohio, 45324, United States

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