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Bone marrow injection may offer longer hip pain relief than steroids

NCT ID NCT04990128

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 10, 2026 · Updated 5 times

Summary

This study tests whether a single injection of concentrated bone marrow cells can reduce pain and improve function in people with hip osteoarthritis better than a standard steroid injection. One hundred adults with moderate to severe hip arthritis will be randomly assigned to receive either the bone marrow concentrate or triamcinolone (a steroid) plus lidocaine. The bone marrow group will have marrow drawn from their hip bone, processed, and then injected back into the joint. The steroid group will get a sham procedure to keep them unaware of their treatment. Researchers will track pain, stiffness, and walking ability for up to a year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bone marrow aspirate concentrate (BMAC)
What this could lead to
If it works, this could offer a longer-lasting pain relief option for hip osteoarthritis without the need for repeated steroid shots.
What could go wrong
This is a single-site, 100-person trial, so results may not apply to everyone. BMAC is a biologic product with variable potency, and its long-term safety and effectiveness are still unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion: 1. Provision of signed and dated consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Male or female, aged between 18 - 75 years old 4. WOMAC Pain Subscale Total Score of 5 or higher in the Likert Scale (total score is 20) 5. Kellgren-Lawrence Grade ≥ 2 on Hip X-Rays 6. Body Mass Index ≤ 35 kg/m\^2 7. Unilateral or Bilateral Hip Osteoarthritis 8. Prior physical therapy treatment for 6 weeks in the last 12 months and compliance with home exercise program 9. Agreement to adhere to Lifestyle Considerations 10. Discontinuation of pain/anti-inflammatory medications 2 week prior to baseline measurements 11. Patients with cancer in remission for at least 5 years. Specific cancers which were treated with surgical resection and are not undergoing chemotherapy/radiation therapy such as breast cancer, colon cancer, or skin cancer, and others could participate when deemed in remission for 1 year. Written approval from oncologist will be necessary prior to enrollment 12. Negative gram stain result Exclusion: 1. Prior corticosteroid injection to the hip 2. History of hip replacement(s) 3. Noncompliance to preventive screening tests for cancer indicated by age 4. Active autoimmune disease 5. Current use of oral corticosteroid 6. Use of immunosuppressive medications, or who are known to me immunocompromised 7. Inability to be weaned of oral anti-inflammatory medications 8. History of Diabetes or HbA1c ≥ 6.5% 9. Uncontrolled Thyroid Dysfunction: 0.450 uIU/mL ≥ TSH levels ≥ 4.500 uIU/mL 10. Vitamin D Level \< 30 ng/ml 11. Anemia (Hgb \< 11.7 g/dL for Women; Hgb \< 13 g/dL for men) 12. eGFR \< 60 mL/min/1.73 m\^2 13. Thrombocytopenia with platelet count less than 150,000 x 10\^9 L 14. Patients with coagulopathies based on known clotting disorder 15. Patients currently on anti-coagulation therapies 16. Patients who report any active infection(s) including cellulitis, TB, HIV, COVID, Hepatitis B and C 17. Moving over the next year 18. Inability to consent to the research study 19. Inability to complete forms electronically 20. Subjects in any other clinical trials 21. History of allergic reaction to lidocaine 22. Pregnancy or planning to be pregnant during trial 23. Breastfeeding

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cleveland Clinic Florida

    RECRUITING

    Weston, Florida, 33331, United States

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