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No knife needed? new procedure may treat appendicitis without surgery

NCT ID NCT07230379

Disease control Sponsor: Changhai Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

This study tests a new, non-surgical treatment called ERAT for mild appendicitis. Instead of removing the appendix, doctors use a flexible tube through the colon to clear the blockage and infection. The trial will compare ERAT to standard laparoscopic surgery in 376 adults to see if it is as safe and effective, with follow-up for one year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Endoscopic Retrograde Appendicitis Therapy (ERAT) - a procedure using a flexible tube through the colon to clear the appendix blockage
What this could lead to
If successful, ERAT could offer a non-surgical option for mild appendicitis, allowing patients to keep their appendix and avoid surgery.
What could go wrong
This is an early-stage trial with only 376 participants, and ERAT may not work for everyone. There is a risk of appendicitis returning, requiring surgery later.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 376 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 18 years. 2. Diagnosis of first-episode acute uncomplicated appendicitis (AUA) confirmed by CT scan of the lower abdomen. AUA is defined as acute appendicitis without evidence of abscess, perforation, gangrene, or tumor. 3. Provision of written informed consent. Exclusion Criteria: 1. Complicated appendicitis, defined as acute appendicitis with perforation, gangrene, periappendiceal abscess or phlegmon, generalized peritonitis, or radiologic evidence of extraluminal appendicolith, extraluminal air, periappendiceal fat stranding, or appendiceal mass. 2. Severe intestinal adhesions or bowel obstruction. 3. Intolerance or contraindication to bowel preparation or colonoscopy (e.g., intestinal perforation or bowel obstruction). 4. Poor general condition precluding tolerance of abdominal surgery. 5. Abdominal pain caused by other diseases as confirmed by CT or other diagnostic examinations, including inflammatory bowel disease, urinary tract disease, or gynecological disease. 6. Pregnancy. 7. Severe dysfunction of major organ systems, including but not limited to cardiac, pulmonary, renal, hepatic, or hematologic systems. 8. Current enrollment in another clinical trial. 9. Any condition that may prevent the participant from completing all study requirements.

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Conditions

The condition(s) this trial relates to.

appendicitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute uncomplicated appendicitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    14 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Gastroenterology, Changhai Hospital, Naval Medical University

    RECRUITING

    Shanghai, 200433, China

  • Department of Gastroenterology, Jilin City People's Hospital

    RECRUITING

    Jilin City, Jilin, 132011, China

  • Department of Gastroenterology, Linyi People's Hospital

    RECRUITING

    Linyi, Shandong, 276000, China

  • Department of Gastroenterology, South China Hospital, Medical School, Shenzhen University

    RECRUITING

    Shenzhen, Guangdong, 518116, China

  • Department of Gastroenterology, The First Affiliated Hospital of Henan University,

    RECRUITING

    Kaifeng, Henan, 475001, China

  • Department of Gastroenterology, The First Affiliated Hospital of Nanchang University

    RECRUITING

    Nanchang, Jiangxi, 330006, China

  • Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University

    RECRUITING

    Zhengzhou, Henan, 450000, China

  • Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University

    NOT_YET_RECRUITING

    Chongqing, Chingqing, 400010, China

  • Department of Gastrointestinal Surgery, Fourth West China Hospital, Sichuan University

    RECRUITING

    Chengdu, Sichuan, 610041, China

  • Department of Gastrointestinal Surgery, Hunan Provincial People's Hospital

    RECRUITING

    Changsha, Hunan, 410005, China

  • Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine

    RECRUITING

    Hangzhou, China

  • Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Soochow University

    NOT_YET_RECRUITING

    Suzhou, Jiangsu, 215008, China

  • Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University

    RECRUITING

    Guangzhou, Guangdong, 510655, China

  • Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University

    RECRUITING

    Changsha, Hunan, 410008, China

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