No knife needed? new procedure may treat appendicitis without surgery
NCT ID NCT07230379
First seen Nov 17, 2025 · Last updated Jun 20, 2026 · Updated 23 times
Summary
This study tests a new, non-surgical treatment called ERAT for mild appendicitis. Instead of removing the appendix, doctors use a flexible tube through the colon to clear the blockage and infection. The trial will compare ERAT to standard laparoscopic surgery in 376 adults to see if it is as safe and effective, with follow-up for one year.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Department of Gastroenterology, Changhai Hospital, Naval Medical University
Shanghai, 200433, China
Contact Email: •••••@•••••
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Department of Gastroenterology, Jilin City People's Hospital
Jilin City, Jilin, 132011, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Gastroenterology, Linyi People's Hospital
Linyi, Shandong, 276000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Gastroenterology, South China Hospital, Medical School, Shenzhen University
Shenzhen, Guangdong, 518116, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Gastroenterology, The First Affiliated Hospital of Henan University,
Kaifeng, Henan, 475001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Gastroenterology, The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University
Chongqing, Chingqing, 400010, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Gastrointestinal Surgery, Fourth West China Hospital, Sichuan University
Chengdu, Sichuan, 610041, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Gastrointestinal Surgery, Hunan Provincial People's Hospital
Changsha, Hunan, 410005, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215008, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, 510655, China
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Contact
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Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University
Changsha, Hunan, 410008, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Endoscopic Retrograde Appendicitis Therapy (ERAT) - a procedure using a flexible tube through the colon to clear the appendix blockage
What this could lead to
If successful, ERAT could offer a non-surgical option for mild appendicitis, allowing patients to keep their appendix and avoid surgery.
What could go wrong
This is an early-stage trial with only 376 participants, and ERAT may not work for everyone. There is a risk of appendicitis returning, requiring surgery later.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.