No knife needed? new procedure may treat appendicitis without surgery
NCT ID NCT07230379
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new, non-surgical treatment called ERAT for mild appendicitis. Instead of removing the appendix, doctors use a flexible tube through the colon to clear the blockage and infection. The trial will compare ERAT to standard laparoscopic surgery in 376 adults to see if it is as safe and effective, with follow-up for one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Endoscopic Retrograde Appendicitis Therapy (ERAT) - a procedure using a flexible tube through the colon to clear the appendix blockage
- What this could lead to
- If successful, ERAT could offer a non-surgical option for mild appendicitis, allowing patients to keep their appendix and avoid surgery.
- What could go wrong
- This is an early-stage trial with only 376 participants, and ERAT may not work for everyone. There is a risk of appendicitis returning, requiring surgery later.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Gastroenterology, Changhai Hospital, Naval Medical University
Shanghai, 200433, China
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Department of Gastroenterology, Jilin City People's Hospital
Jilin City, Jilin, 132011, China
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Department of Gastroenterology, Linyi People's Hospital
Linyi, Shandong, 276000, China
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Department of Gastroenterology, South China Hospital, Medical School, Shenzhen University
Shenzhen, Guangdong, 518116, China
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Department of Gastroenterology, The First Affiliated Hospital of Henan University,
Kaifeng, Henan, 475001, China
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Department of Gastroenterology, The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
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Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450000, China
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Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University
Chongqing, Chingqing, 400010, China
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Department of Gastrointestinal Surgery, Fourth West China Hospital, Sichuan University
Chengdu, Sichuan, 610041, China
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Department of Gastrointestinal Surgery, Hunan Provincial People's Hospital
Changsha, Hunan, 410005, China
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Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, China
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Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215008, China
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Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, 510655, China
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Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University
Changsha, Hunan, 410008, China
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