New study tracks sinus health in kids with cystic fibrosis on breakthrough drugs
NCT ID NCT06191640
First seen Nov 01, 2025 · Last updated Jun 20, 2026 · Updated 35 times
Summary
This study follows 80 children aged 2-8 with cystic fibrosis to see how highly effective CF drugs (Kalydeco or Trikafta) impact sinus disease and sense of smell. Researchers will use MRI scans, smell tests, and quality-of-life surveys over two years. The goal is to understand whether these drugs improve sinus and olfactory problems in young children.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229-3039, United States
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
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University of Kansas Medical Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Vermont
RECRUITINGColchester, Vermont, 05446, United States
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University of Virginia
RECRUITINGCharlottesville, Virginia, 22903, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ivacaftor or elexacaftor/tezacaftor/ivacaftor (Kalydeco or Trikafta)
What this could lead to
If successful, this could show that CF drugs improve sinus and smell issues in young children, guiding better treatment.
What could go wrong
This is an observational study, not a treatment trial, so it cannot prove cause and effect. Results may not apply to all children.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.