Tooth pulp test may reveal which deep cavities heal without a root canal
NCT ID NCT07825415
First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time
Summary
Researchers at a dental institute in India are studying whether levels of two inflammation markers, IL-1beta and IL-6, in the tooth's pulp can predict how well a full pulpotomy works. The procedure removes the inflamed crown portion of the pulp, caps it with a mineral-based material, and leaves the root pulp intact. The study enrolls 86 healthy adults aged 18 to 40 with extremely deep cavities in lower molars and moderate or severe pulpitis. Dentists measure the markers from a small pulp blood sample, then track clinical and X-ray success at 6 and 12 months to see if marker levels match healing.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- full pulpotomy, a dental procedure that removes the inflamed crown portion of the tooth's pulp and caps it with a mineral-based material
- What this could lead to
- If the marker levels line up with outcomes, dentists could one day use a quick pulp test to decide which teeth will heal after a pulpotomy and which need a root canal.
- What could go wrong
- This is a small observational study of 86 people at one dental school, so it can show a link but not prove cause. Marker levels may not predict outcomes well enough to change practice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 86 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2026
- Expected to finish
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Apr 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * o Medically healthy patients (ASA 1). * Age 18-40 years * Patients with extremely deep caries in permanent mandibular molars. * Extremely deep caries, that is penetrating the entire thickness of the dentine without a radiopaque zone separating the lesion from the pulp * PAI score less then or equal to 2 * Pulpal diagnosis via clinical and radiographic examination as well as thermal, electric pulp testing, categorized as moderate pulpitis (Heightened and prolonged reaction to cold, which can last for minutes Possible percussion sensitive Stimulated or spontaneous lingering pain that can be suppressed with analgesics. No sleep disturbance) or severe pulpitis (Severe spontaneous pain Clear lingering pain reaction to cold and warms stimuli Sleeping disturbance and lingering pain Possible sensitive to percussion Extremely deep caries mostly). Exclusion Criteria: * • Primary teeth * Traumatic or mechanical exposure * No pulp exposure after caries excavation. * Haemostasias not achieved within 10 minutes. * Presence of periapical lesion or evidence of internal or external resorption, calcified canals, as assessed by radiographic examination. * Patients with periodontal disease, swelling and sinus tract. * Immunocompromised or pregnant patients, patients with any systemic disease, and a positive history of antibiotic and analgesic use within week before the treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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PGIDS, Rohtak
RECRUITINGRohtak, Haryana, 124001, India
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