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Can natural mouthwashes fight cavity bacteria as well as chlorhexidine?

NCT ID NCT07828171

Prevention Sponsor: British University In Egypt Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 18, 2026 · Last updated Sep 18, 2026

Summary

Researchers are testing three mouthwashes, licorice, clove, and chlorhexidine, in Egyptian children aged 7 to 12 who have a high risk of cavities. The trial measures levels of Streptococcus mutans, a bacterium linked to tooth decay, in saliva before and after children use their assigned mouthwash. The goal is to see whether the herbal mouthwashes reduce this bacterium as effectively as chlorhexidine, which can cause unwanted effects when used for a long time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
licorice and clove mouthwashes compared with chlorhexidine mouthwash
What this could lead to
If licorice or clove mouthwash works well, families could have a natural, low-cost option to help prevent cavities in children, especially when chlorhexidine causes side effects with long use.
What could go wrong
This is a small, single-country study in children with a high cavity risk, so results may not apply to everyone. Herbal mouthwashes can vary in strength, and some children may dislike the taste or have allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

7 to 12 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pediatric patients with high caries index based on CAMBRA. * Frankl scale 3 and 4 (cooperative). Exclusion Criteria: * Patients with teeth showing signs of infection (abscess or fistula) * Patients with mucositis (can't be given alcohol containing mouthwashes) * Hypertensive patients. * Allergic patients. * Special health care patients.

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Conditions

The condition(s) this trial relates to.

dental caries streptococcal infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries Mouthwashes Streptococcal infections

Contacts and locations

Locations

  • The British university in Egypt

    Cairo, Cairo Governorate, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.