Inflammatory disease

Researchers test a surgical technique that uses a boomerang-shaped piece of the patient's own cartilage and tissue to repair hard-to-close eardrum perforations. The study includes 50 adults with anterior or subtotal perforations that have been dry for at least three months. Surge…

This phase 2 trial is testing whether a single infusion of a patient's own genetically modified immune cells, called C-CAR168, can safely and effectively treat lupus nephritis that has not responded to standard therapies. The cells are designed to target and eliminate specific im…

Researchers are testing whether adding a PD-1 antibody and pegylated interferon to standard antiviral pills can help people with chronic hepatitis B lose the hepatitis B surface antigen. The trial enrolls adults whose virus is already suppressed by nucleos(t)ide analogues and who…

This trial tests a therapy called CTX112 in adults with severe neurologic autoimmune diseases, including progressive multiple sclerosis, neuromyelitis optica, and stiff-person syndrome. CTX112 uses donor T cells edited with CRISPR to target and deplete B cells, which are thought …

This early-phase trial tests whether a single infusion of CD19 CAR-T cells, called TranspoCART19, is safe and can push severe lupus nephritis into remission. Lupus nephritis is a serious kidney complication of lupus that often resists standard treatments. Ten adults with refracto…

This trial is testing whether an experimental mRNA vaccine can safely reduce moderate-to-severe acne in adolescents aged 12 to 17. Participants receive either the vaccine at different dose levels or a placebo, and researchers monitor safety and changes in facial acne lesions. The…

This Phase 3 trial tests updated versions of the BNT162b2 COVID-19 vaccine in adults and children aged 5 and older. Participants include those aged 5 to 64 with medical conditions that raise their risk of severe COVID-19, as well as everyone aged 65 and older. The study compares …

Researchers are testing an experimental oral drug called VC005 in teenagers aged 12 to 17 who have non-segmental vitiligo, a condition where patches of skin lose their color. The study measures how the drug moves through the body and checks for safety over up to 24 weeks of treat…

This early-stage trial tests an oral capsule containing a genetically modified probiotic yeast designed to neutralize toxins produced by C. diff bacteria. The study first evaluates safety in healthy adults, then in people at risk for recurrent C. diff infection. Participants take…

This early-stage trial is testing an experimental drug called SNC116 in people with refractory systemic lupus erythematosus (SLE), a form of lupus that hasn't improved with standard treatments. The study aims to see if a single intravenous infusion of SNC116 is safe and tolerable…

This study compares four different sequences of biologic drugs (infliximab, filgotinib, ustekinumab, and vedolizumab) in 240 adults with moderate to severe ulcerative colitis. The goal is to see which order of treatments works best to achieve and maintain remission without steroi…

Researchers are testing a new way to deliver antibiotics to the brain in people with moderate to severe bacterial meningitis who are not improving on standard intravenous treatment. The approach combines standard IV antibiotics with a continuous infusion of three antibiotics (van…

This study looks back at the experiences of 35 adults with a rare kidney disease called C3G who received the drug iptacopan through a special early access program in Spain. Researchers will collect information on patient health, lab results, and how the disease responds to treatm…

Acute uncomplicated diverticulitis is often treated with antibiotics, but evidence suggests they are not always needed. This study evaluates whether a standardized treatment approach based on clinical findings, lab results, other health conditions, and CT scans can reduce unneces…

Researchers test whether coconut oil pulling or a moringa mouthwash can reduce gingivitis in children with diabetes, compared with chlorhexidine. Thirty children aged 6 to 12 with mild to moderate gingivitis use one of the three rinses. The team measures gum inflammation and leve…

This phase 2 trial is investigating whether an experimental drug called ARGX-121 can improve outcomes for adults with IgA nephropathy, a kidney disease that can lead to kidney failure. Participants will receive either ARGX-121 or a placebo, while continuing their usual care. The …

Researchers compare two ways to treat deep defects in the gums of people with advanced periodontitis. One approach cleans the pockets with minimally invasive non-surgical therapy, while the other uses a single flap surgical procedure. The trial measures gum attachment gain and us…

This study tests a digital health program designed to support people with psoriatic arthritis in managing their condition. Participants use a mobile app for symptom tracking and lifestyle tips, plus tools for sleep, stress, and physical activity, along with a smartwatch. The goal…

This phase III trial tests whether the oral drug nerandomilast can improve symptoms of idiopathic inflammatory myopathies, a group of rare autoimmune diseases that cause muscle weakness and inflammation. Adults with active myositis are randomly assigned to take nerandomilast or a…

Researchers test whether a rinse made from frankincense (Boswellia sacra) removes bacteria from infected root canals as well as the standard sodium hypochlorite rinse. Thirty adults aged 18 to 50 with a dead or infected tooth take part. Each person is randomly assigned to one of …

This study tests whether a pharmacist-led electronic consultation can improve lung health for people with HIV who smoke or use certain medications that raise pneumonia risk. Pharmacists will review records and suggest changes like smoking cessation aids, vaccines, or stopping unn…

Researchers at a Malaysian hospital reviewed ten years of records for 160 adults who received intrapleural fibrinolytic therapy, a mix of alteplase and DNase delivered through a chest tube, for complicated pleural infection. The study compares how well the treatment cleared fluid…

Researchers are tracking how long adults with moderate to severe Crohn's disease or ulcerative colitis keep taking guselkumab, a biologic drug, in routine care. The study follows about 400 people who start the treatment and records when they stop. It also checks whether early imp…

Researchers are testing whether abrocitinib, an oral medicine taken once daily as a liquid, safely improves moderate-to-severe eczema in children aged 2 to under 6. About 90 children with a documented eczema diagnosis for at least a year will join. Two out of three will receive a…

Researchers are running a phase 1 trial to find out how safe and tolerable ATTO-1091 is in healthy adults and in people with ulcerative colitis. The study also measures how long the drug stays in the body. About 96 participants will receive either ATTO-1091 or a placebo, visit th…

Researchers are testing whether nitazoxanide, an antiparasitic drug with anti-inflammatory properties, can help people with mild-to-moderate ulcerative colitis when added to their usual treatment. The trial enrolls adults aged 18 to 65 with active disease and stable therapy. Over…

Researchers are testing whether adding atrasentan to standard supportive care improves kidney structure and function in adults with IgA nephropathy, a condition where the immune system damages the kidneys. About 20 participants will take atrasentan 0.75 mg once daily for 52 weeks…

This trial tests whether screening older adults for sarcopenia (loss of muscle strength and mass) before hip replacement surgery, followed by a structured exercise program after surgery, can improve recovery. Participants aged 65 and older with advanced hip osteoarthritis will be…

When a kidney stone blocks urine flow and causes a severe infection, doctors must quickly relieve the blockage and control the infection. They can place a stent through the urinary tract, insert a drainage tube through the skin, or start antibiotics alone. This study observes 1,6…

This trial tests an experimental drug called PF-08154225 in people with autoimmune diseases like lupus, rheumatoid arthritis, myositis, or scleroderma. The drug aims to calm the immune system, which mistakenly attacks healthy cells in these conditions. Participants receive the dr…

This early-stage trial is testing a new drug called ACT500 in 24 people who have both fatty liver disease and chronic hepatitis B. The main goal is to check the drug's safety and how the body processes it at different doses. Participants will take ACT500 or a placebo daily, and r…

This early-stage study tests a new oral drug called ACT500 in 24 adults with fatty liver disease (MASLD). The main goal is to check safety and how the drug moves through the body. Participants take one pill daily in different dose groups. The study does not aim to cure the diseas…

This pilot study tests whether a home-based device that stimulates the vagus nerve through the ear can reduce pain and inflammation in veterans with knee osteoarthritis. Researchers will compare two different daily doses of this nerve stimulation against a standard steroid inject…

Researchers are testing whether a toothpaste containing isopropyl methyl phenol reduces plaque buildup and gum bleeding better than a regular fluoride toothpaste. The 12-week study enrolls 120 Chinese adults with plaque-induced gingivitis. Dentists measure gum bleeding at weeks 2…

This early-phase trial is testing a new cell therapy called GT719 for several immune-mediated kidney diseases, including IgA nephropathy and membranous nephropathy. The therapy uses specially engineered immune cells to target and potentially control the disease. The study will en…

This trial tests whether adding nicorandil, a drug that widens blood vessels, to standard rheumatoid arthritis (RA) treatment can reduce the buildup of plaque in arteries. People with RA have a higher risk of atherosclerosis, which can lead to heart attacks and strokes. Researche…

Researchers are testing a treatment plan that uses two drugs, remibrutinib and omalizumab, in adults with chronic spontaneous urticaria whose hives and itching are not controlled by standard antihistamines. The study follows about 382 adults across multiple centers worldwide. The…

This trial tests whether adding laser therapy to standard gum surgery improves treatment of advanced periodontitis. Adults with stage I to III periodontitis who still have deep pockets after initial non-surgical care will receive open flap debridement, a procedure that lifts the …

This phase 2 trial tests whether injecting botulinum toxin (Botox) into skin affected by hidradenitis suppurativa (HS) can reduce the number of painful abscesses, nodules, and draining tunnels, and ease pain. About 40 people with HS will receive either Botox or a saline placebo i…

This study tests whether oral vancomycin, an antibiotic, can help children aged 6-15 with inflammatory bowel disease (IBD), especially types linked to liver problems. About 140 kids will either get vancomycin plus standard care or standard care alone for up to a year. Researchers…

Researchers are testing different doses of duvakitug, an injected drug, against placebo in adults with moderate to severe hidradenitis suppurativa. The trial enrolls about 156 people who have painful lumps and tunnels in at least two skin areas. Participants receive either duvaki…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

Researchers in Oman are testing whether a structured education program that combines diabetes and oral health advice can improve blood sugar control and gum health in adults with type 2 diabetes. The trial enrolls 290 adults aged 35 and older who have had type 2 diabetes for at l…

This trial tests whether an oral medication called zasocitinib (TAK-279) can reduce the redness, thickening, scaling, and painful cracks of palmoplantar psoriasis, a type of psoriasis that affects the palms and soles. Adults with moderate-to-severe non-pustular palmoplantar psori…

This study tests whether metformin, a standard diabetes medicine, can slow the worsening of idiopathic pulmonary fibrosis (IPF), a serious lung disease. About 400 high-risk patients will receive either metformin or a placebo. The goal is to see if metformin can delay death, hospi…

This trial tests the long-term safety and effectiveness of povetacicept, an investigational drug given as a subcutaneous injection, in adults with immunoglobulin A nephropathy (IgAN), a kidney disease that can lead to kidney failure. Participants who completed the earlier parent …

This study compares two treatment combinations for adults with psoriatic arthritis who did not get enough relief from methotrexate alone. One group will receive apremilast plus methotrexate, the other adalimumab plus methotrexate. Researchers will measure joint and skin disease a…

This trial tests whether adding a gel made from a patient's own blood, called albumin platelet-rich fibrin, improves the results of regenerative surgery for severe gum disease. Adults with stage III periodontitis and deep bone defects will receive standard surgery with a bone gra…

This study tests whether using an electric flosser along with a manual toothbrush and fluoride toothpaste reduces plaque and gum inflammation more than brushing alone. About 80 adults with mild gum disease will follow one of two routines for 30 days. Researchers will measure chan…

This trial tests whether inhaling bacteriophages, which are viruses that specifically kill Pseudomonas aeruginosa bacteria, can help clear a serious lung infection in patients on breathing machines. The study includes adults with ventilator-associated pneumonia caused by this bac…

This study explores whether giving people with mild-to-moderate eczema a straightforward treatment plan using only Opzelura cream helps them stick to their medication routine. Participants apply the cream twice daily until their skin clears, then as needed. Some participants also…

This trial tests an experimental drug called SGC001 in people who are likely to develop severe acute pancreatitis, a painful inflammation of the pancreas that can lead to organ failure. Participants receive either SGC001 or a placebo as a single intravenous infusion alongside sta…

This trial gives deucravacitinib, an oral drug that calms the immune system, to adults with lupus or Sjögren's disease and to children with psoriasis or psoriatic arthritis. Participants join after finishing an earlier study of the same drug, and the goal is to see how safe and t…

This Phase 3 trial tests whether a multi-component oral hygiene regimen, including specific mouthwashes and toothpaste, improves outcomes in adults with stage II periodontitis undergoing non-surgical periodontal treatment. Participants will use either an active regimen or a place…

This early-stage trial tests an experimental drug called HXN5003 in healthy volunteers and in people with moderate-to-severe atopic dermatitis, a common form of eczema. The study first gives a single dose to healthy participants to check safety, then gives multiple doses to eczem…

This study tests whether injecting stem cells into the eye can help people with severe dry eye caused by graft-versus-host disease (GVHD), a complication of bone marrow transplants. The trial will include 30 adults who have not improved with standard treatments. Participants will…

This trial tests whether adding the drug mirogabalin to a structured educational and behavioral program improves symptoms for adults with interstitial cystitis or bladder pain syndrome. Participants receive either the behavioral program alone or the program plus mirogabalin for 1…

This trial is testing whether a 10-week course of fluconazole works as well as the standard 24-week course for people with HIV who have a cryptococcal infection in their blood (antigenemia) but no symptoms. It also compares starting HIV medications right away versus waiting 14 da…

This 52-week study will compare three drugs—tocilizumab, telitacicept, and methotrexate—in 204 people with rheumatoid arthritis who also have interstitial lung disease. The main goal is to see which drug best improves lung function. Participants will continue their usual arthriti…

This Phase 1 trial tests a single oral dose of HRS-4139, an experimental drug for psoriasis, in healthy adults aged 18 to 55. Researchers measure how the body absorbs and processes the drug, and watch for any side effects. The goal is to establish a safe dose for future studies i…

This trial tests whether adding an experimental drug called TQA3605 to standard antiviral therapy helps more adults with chronic hepatitis B reach undetectable virus levels. About 930 participants who have been on antiviral treatment for at least a year will receive either TQA360…

This trial tests whether a special cooling tube placed near the pancreas can help people with acute pancreatitis recover faster. Participants are randomly assigned to receive either standard care alone or standard care plus the cooling device for up to three days. The study measu…

This study looks at whether a preventive endoscopic procedure (sphincterotomy) can lower the risk of future bile duct problems in frail patients who cannot have their gallbladder removed after a bout of pancreatitis caused by gallstones. About 92 adults will be randomly assigned …

This trial tests whether adding a nasal spray made from pistacia lentiscus oil can help people with chronic rhinosinusitis control their symptoms while using a lower dose of a standard corticosteroid spray. Adults with the condition will be randomly assigned to either the oil spr…

This trial tests whether adding Bacillus probiotic spores to standard treatment can help people with Crohn's disease or ulcerative colitis. Researchers will give 150 adults either a placebo or one of two probiotic formulas for 30 days, alongside their usual care. The goal is to s…

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This phase 1 trial tests the safety and tolerability of LMT503, an oral drug intended for inflammatory bowel disease, in healthy adults aged 18 to 65. Participants receive either LMT503 or a placebo in single or multiple ascending doses, with some also checking how food affects t…

This trial tests whether TECAR therapy, which uses capacitive and resistive energy to heat deep tissues, can improve tendon thickness, reduce pain, and restore shoulder movement in people with supraspinatus tendinitis. Researchers will compare TECAR therapy to conventional physio…

This trial looks at people who have both periodontitis (gum disease around natural teeth) and peri-implantitis (inflammation around dental implants). Researchers will measure three proteins in the fluid around teeth and implants before and after routine non-surgical therapy, whic…

This trial tests whether Lacrifill, a gel placed in the tear duct to block tear drainage, can reduce dry eye symptoms in people who have had cataract surgery. Participants receive either Lacrifill or standard saline eye drops, and researchers compare eye discomfort scores over th…

This study follows over 2,000 elderly patients hospitalized with community-acquired pneumonia to see whether adding traditional Chinese medicine (TCM) to standard care improves recovery. Researchers will compare patients who receive TCM with those who do not, tracking hospital st…

This observational study tracks how long patients with moderate-to-severe Crohn's disease or ulcerative colitis continue taking guselkumab, a biologic treatment, in everyday clinical practice. Researchers will measure time until treatment discontinuation and early responses like …

This early-stage trial will test whether injecting adalimumab (Humira) into the eye during Boston KPro surgery is safe for 8 patients with severe corneal damage. The study focuses on side effects and tolerability, not yet on how well it works. It is for people who have run out of…

This trial tests whether a single oral dose of ondansetron, a drug that curbs vomiting, can help children with cholera keep down oral rehydration solution (ORS). About 120 children aged 6 months to 17 years with suspected or confirmed cholera and active vomiting will receive eith…

This trial tests whether adding a gel made from a patient's own blood, called albumin platelet-rich fibrin (Alb-PRF), to standard nonsurgical gum treatment improves healing of deep gum pockets in adults with periodontitis. Each participant has matched gum sites randomly assigned …

This trial tests whether a dietary fiber called resistant potato starch can reduce the amount of drug-resistant bacteria living in the gut. The study enrolls Veterans who carry these bacteria without symptoms, and half will take the starch daily while the other half takes a place…

This trial tests whether draining the gallbladder through an endoscope works better than the standard percutaneous approach for people with acute cholecystitis who are too sick for surgery. Researchers will randomly assign 212 participants to receive either endoscopic ultrasound-…

This trial tests whether adding inspiratory muscle training (IMT) — breathing exercises using a resistance device — to usual care can improve cardiopulmonary endurance and functional mobility in people with knee osteoarthritis. Adults aged 40-65 with bilateral knee osteoarthritis…

This trial tests whether combining traditional Ayurvedic treatments with standard medical care can better ease knee osteoarthritis symptoms than either approach alone. It enrolls 300 adults aged 30-65 with mild to moderate knee osteoarthritis, randomly assigning them to receive s…

This trial tests whether a gel made from a patient's own blood, called injectable platelet-rich fibrin (I-PRF), can improve the results of a minimally invasive non-surgical treatment for advanced gum disease. Researchers will compare three approaches: the standard deep-cleaning p…

This trial compares fungal-based pancreatic enzymes to standard pig-derived enzymes in people with chronic pancreatitis and digestive insufficiency. Participants take either the fungal or porcine enzyme for 12 weeks to see if the fungal version works just as well. The goal is to …

This study tests whether hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — can help heal perianal fistulas in people with Crohn's disease who haven't improved with standard treatments. Participants will either receive HBOT or continue with conven…

This trial tests whether genistein, a natural compound found in soy, can reduce inflammation and improve blood vessel health in people living with HIV. Even with effective HIV treatment, the body stays inflamed, raising the risk of heart disease and other problems. The study give…

This trial tests whether eyedrops made from a patient's own blood plasma, rich in growth factors (PRGF), can reduce symptoms of severe dry eye disease. About 100 adults with severe dry eye will use either PRGF or a placebo solution alongside their standard treatment for one month…

This pilot trial is testing a digital health program called CHALAANE, which means 'walk' in Hindi and Urdu, for South Asian adults with knee osteoarthritis and obesity. The program combines a smartband, an AI-powered mobile app for tracking diet and activity, and a 12-week superv…

This trial compares two oral medications for active ulcerative colitis, a chronic inflammatory bowel disease causing diarrhea, bleeding, and pain. About 320 Chinese adults will be randomly assigned to take either etrasimod, a newer drug that blocks immune cells from entering the …

This trial is testing an experimental therapy called CTA313, which uses engineered immune cells (CAR T cells) to potentially reset the immune system in people with active autoimmune diseases. The study will include adults aged 18 to 75 with systemic lupus erythematosus, progressi…

This trial is testing an investigational drug called brenipatide in adults with moderate-to-severe COPD. Participants will receive either brenipatide or a placebo for about a year, alongside standard care. The goal is to see if brenipatide improves lung function and reduces the n…

This Phase 3 trial is testing whether an experimental biologic called tilrekimig can reduce the severity of moderate-to-severe atopic dermatitis (eczema) in people aged 12 and older. Participants will receive either tilrekimig, an existing treatment (dupilumab), or a placebo for …

This trial is testing whether combining the drug mirikizumab with a surgical procedure can help heal perianal fistulas in people with Crohn's disease. Participants will receive the drug through infusions and injections, along with two surgical steps to clean and close the fistula…

This trial tests whether two oral antibiotic combinations—doxycycline with levofloxacin or moxifloxacin—can treat brucellosis as effectively as the standard doxycycline-rifampicin regimen. Brucellosis is a bacterial infection from animals that can cause fever and joint pain, and …

This study is following people who receive a Tornier Perform™ Reversed MonoPost shoulder replacement to see how well it works and how safe it is. The implant is designed for patients with severe shoulder damage, such as from arthritis, fractures, or failed previous surgeries. Res…

This clinical trial aims to find the safest and most effective hepatitis C treatment for people with chronic kidney disease (CKD). Researchers will compare two drug combinations based on how well the kidneys are working: one for patients with moderate kidney function and another …

This trial asks whether GLP-1 receptor agonists, a class of drugs used for weight management, can improve gum health and boost the response to standard deep-cleaning treatment in people with obesity and periodontitis. Adults with both conditions will be split into two groups: tho…

This trial is testing whether a minimally invasive technique for robotic knee replacement, which uses a smaller incision and less tissue disruption, can improve scar appearance and recovery compared to the standard approach. The study will involve 100 adults with knee osteoarthri…

This study tests a drug called inebilizumab in 180 adults with autoimmune hepatitis, a condition where the immune system attacks the liver. The goal is to see if the drug can reduce liver inflammation and allow patients to take lower doses of steroids. Participants will receive e…

This study follows about 1,020 people who receive the oneKNEE total knee prosthesis during knee replacement surgery. Researchers track safety and how well the implant works by measuring changes in knee pain and function using the Oxford Knee Score two years after surgery. The goa…

This trial tests whether replacing some of the usual diet with navy beans — without changing total calories — is a practical and acceptable way to help manage metabolic dysfunction-associated steatotic liver disease (MASLD) in adults with intermediate-stage liver fibrosis. Forty …

This phase 2 trial is testing whether pirfenidone, a drug already used for lung scarring, can help people with chronic pancreatitis—a long-term inflammation of the pancreas that causes severe pain. The study will enroll 60 adults with chronic pancreatitis and moderate-to-severe p…

This trial is testing whether a probiotic supplement called Colipral, which contains a specific strain of E. coli bacteria, can improve gut health in people with ulcerative colitis who are in remission but still have digestive issues. Participants will take either the supplement …

This first-in-human trial evaluates BYN-001, an antibody designed to block IL-25, a protein linked to atopic dermatitis (eczema). The study first tests the drug in healthy volunteers to assess safety and how it moves through the body, then in people with moderate to severe eczema…

This trial tests whether extra follow-up—via phone calls, digital messages, or both—helps people recover better after a tooth extraction. Adults having a tooth pulled will get standard instructions, and some will also receive structured phone or digital check-ins during the first…

This trial is testing whether adding the nerve pain medication pregabalin to a structured educational and behavioral program can better ease the symptoms of bladder pain syndrome (also called interstitial cystitis) than the program alone. Adults with this condition will be random…

This trial tests whether a one-time injection of a person's own concentrated fat can reduce pain and improve function in adults with chronic tendinopathy—tendon pain lasting more than three months that hasn't improved with usual treatments. Participants undergo a same-day procedu…

This early trial is testing an experimental biologic drug called aletekitug in adults with moderate to severe ulcerative colitis. The main goal is to see if the drug is safe and tolerable when given repeatedly. Researchers will monitor side effects and changes in lab tests, vital…

This trial tests a new surgical technique that avoids cutting the gum tissue between teeth to repair deep bone defects caused by gum disease. The procedure uses a synthetic bone graft and a special gel to help the bone regenerate. The study includes 60 adults aged 35 to 65 with a…

This trial tests whether a medicine called emapalumab, which calms a specific part of the immune system, can prevent liver failure in children aged 1 year and older with severe hepatitis that hasn't improved with steroids. The study includes a screening group to observe all sever…

This study looks at how well upadacitinib, a daily pill, works compared to biologic injections for people with moderate-to-severe atopic dermatitis (eczema). The goal is to see if more patients can reach a state of minimal disease activity, meaning nearly clear skin and little to…

This study tests whether a temporary higher dose of upadacitinib (45 mg daily) can bring ulcerative colitis back under control in adults whose disease flared up while on the standard 30 mg maintenance dose. Participants receive the higher dose for 8 to 16 weeks, then may step dow…

This trial tests whether common antibiotics—amoxicillin or amoxicillin-clavulanate—actually reduce symptoms in children aged 2 to 12 with acute sinusitis. About 1,100 children are randomly assigned to one of the two antibiotics or a placebo, and parents track daily symptoms. The …

This study follows over 500 hospitalized adults with drug-resistant bacterial pneumonia to see whether those who receive systemic traditional Chinese medicine (such as herbal decoctions or injections) have fewer lower respiratory tract infections in the six months after leaving t…

This trial investigates whether antibiotics like amoxicillin or amoxicillin-clavulanate ease symptoms of ear infections (acute otitis media) in children aged 6 months to 3 years better than a placebo. Over 1,100 children are randomly assigned to one of three groups, and families …

This phase 2 trial tests whether an experimental drug called HSK50042 can improve lung function in adults with idiopathic pulmonary fibrosis (IPF), a chronic condition that causes lung scarring and breathing difficulties. Participants take HSK50042 or a placebo once daily for 26 …

This study tests whether adding a combination of curcumin (from turmeric) and QingDai (a traditional Chinese herb) to standard vedolizumab treatment can help people with moderate to severe ulcerative colitis reach remission. About 160 adults will receive either the herbal combo o…

This phase II trial tests whether obinutuzumab, a B-cell targeting antibody, can alone achieve complete kidney response in people with pure class V lupus nephritis—a form of lupus kidney disease with no approved treatments. Participants receive up to four infusions over seven mon…

This trial asks whether adults with ulcerative colitis who are in deep remission can safely stop taking their JAK inhibitor medication (tofacitinib, upadacitinib, or filgotinib) instead of continuing daily maintenance therapy. Half of the 224 participants will stop treatment and …

This trial compares two types of platelet-rich plasma (PRP) injections for people with tennis elbow that hasn't improved with standard treatments. One injection uses PRP made from the patient's own bone marrow, while the other uses PRP from their blood. The study aims to see if t…

This study tests whether a 12-week program combining a weekly injection of mazdutide (a drug that targets gut hormones) with lifestyle counseling can quickly reduce liver fat in overweight or obese people who want to donate part of their liver but are temporarily disqualified due…

This study investigates whether a daily probiotic lozenge containing Limosilactobacillus reuteri can reduce inflammation and improve gum health in adults with severe periodontal disease. Researchers will also analyze participants' oral and gut bacteria to identify who is most lik…

This trial compares robotic-assisted total knee replacement to the conventional manual approach in adults with knee osteoarthritis. All participants follow the same structured home-based rehabilitation program before and after surgery. The study measures knee pain, function, and …

This clinical trial tests whether injecting a person's own purified blood cells into the knee can reduce pain and improve movement in people with knee osteoarthritis. The study compares two doses of these cells against a standard steroid injection. Participants are adults aged 40…

This trial compares a standardized siwak (chewing stick) oral hygiene program to conventional toothbrushing for improving gum health in young adults with gingivitis. Participants are dental students aged 18–24 who will follow either the siwak module or toothbrushing for 21 days. …

This study looks at how the oral medication etrasimod works for Chinese adults with active ulcerative colitis (UC) in real-world settings. About 500 participants will take etrasimod as part of their routine care and be followed for at least 52 weeks. Researchers will track change…

This trial tests whether a device that uses alternating magnetic fields to heat metal knee implants can help treat infections without removing the implant. Adults with a knee implant infection receive surgery, antibiotics, and either active or sham magnetic treatment. The study m…

This study tests whether a vaginal ovule device, used alongside standard antibiotics or antifungals, improves vaginal health in women with bacterial vaginosis or yeast infections. Eighty women aged 18 to 60 receive either the active device or a placebo ovule over three treatment …

This trial investigates whether children and young adults with juvenile idiopathic arthritis (JIA)-related uveitis can safely take adalimumab injections less frequently without their eye or joint inflammation returning. Participants are assigned to receive injections every 2, 4, …

This study tests whether community health workers (CHWs) can help people with rheumatic heart disease (RHD) take their monthly antibiotic shots consistently. The trial will enroll about 308 participants in Brazil and Timor-Leste, including adults and children with RHD and their c…

This study compares a long-acting antibiotic called dalbavancin to standard therapy for treating infective endocarditis, a serious infection of the heart valves caused by certain bacteria. Dalbavancin is given as one or two intravenous infusions, while standard therapy requires d…

This trial investigates whether adding bacteriophages—viruses that specifically target and kill bacteria—to standard surgery and antibiotics can improve outcomes for people with infected hip or knee replacements. The study enrolls adults with an infection caused by Staphylococcus…

This study tests whether a standardized care pathway called RICA helps people recover faster after emergency keyhole surgery for moderate gallbladder inflammation (Grade II acute cholecystitis). The pathway includes steps like ultrasound before surgery, limited fasting, blood sug…

This trial investigates whether people with chronic non-infectious uveitis—an eye condition that can cause blindness—can safely reduce their dose of adalimumab (a drug that calms the immune system) by using regular blood tests to monitor drug levels. Participants whose uveitis ha…

This phase 2 study tests whether the drug bepirovirsen can achieve a functional cure for chronic hepatitis B in 30 adults with low virus levels. Participants receive weekly injections for 24 weeks and undergo liver biopsies to measure changes in the virus and immune response. The…

This study tests a medicated foam called roflumilast applied daily to hidradenitis suppurativa (HS) lesions for 16 weeks. It includes adolescents and adults with mild to moderate HS (Hurley stage I or II) who have 4 to 10 painful lumps or abscesses but no draining tunnels. The ma…

This trial tests a new toothpaste containing a Bio-Descaling Powder (BDP) to see if it can reduce hardened dental plaque (calculus) and gum inflammation. It includes 100 adults with gum disease or who are in a gum maintenance program. Participants brush with either the BDP toothp…

This study looks at whether starting secukinumab early in people with moderate-to-severe hidradenitis suppurativa (a chronic skin condition causing painful lumps) can slow disease progression. Researchers will analyze data from existing medical records and registries across Europ…

This trial tests whether closing the surgical wound immediately after cleaning it with a special high-pressure irrigation technique (HIEDI) is as good as or better than waiting a few days to close it. The study involves 200 people aged 12 and older who have open surgery for compl…

This study tests whether adding a Mediterranean-style meal delivery program to resmetirom therapy improves liver health more than resmetirom alone. It involves 120 adults with non-cirrhotic MASH who are starting resmetirom. Participants either receive the drug plus 10 medically t…

This study compares two treatments—albumin and fresh frozen plasma—for children with idiopathic nephrotic syndrome who have fluid buildup that doesn't respond to standard diuretics. The goal is to see which approach resolves swelling faster and more safely. Fifty-six children age…

This study tests an experimental oral drug called JAB-8263 in adults with active rheumatoid arthritis. The goal is to see if it is safe and can reduce joint inflammation and pain. Participants take the drug or a placebo every other day for 28 days. The trial is small and early-st…

This Phase II trial tests whether a combination of therapeutic plasma exchange (filtering the blood), rituximab (a drug that targets certain immune cells), and intravenous immunoglobulin (IVIg) can slow lung decline in people with progressive idiopathic pulmonary fibrosis (IPF). …

This study tests whether oxymetazoline, a common nasal decongestant, can replace sodium hypochlorite as a bleeding control agent during pulp treatment in children's baby teeth. About 50 Egyptian children aged 4-8 with decayed molars will receive either treatment. The goal is to s…

This trial investigates whether flushing the bile duct opening with ice-cold water after an ERCP procedure can reduce the chance of developing pancreatitis, a frequent complication. Researchers will compare patients who receive the flush to those who do not, looking at pancreatit…

This study tests whether ulinastatin, a drug that reduces inflammation, can help patients with severe abdominal infections. The infection often causes the immune system to overreact, leading to organ failure and high risk of death. Researchers will give patients either a low or h…

This study looks at whether a special gel, called Sterify Gel, can improve the results of standard non-surgical gum disease treatment. Researchers will review records from 20 adults with moderate to severe periodontitis who received deep cleaning plus the gel. The main goal is to…

This phase 2 trial tests whether eye drops containing infliximab, a drug that blocks a key inflammatory protein, can safely improve severe dry eye in people with Sjögren's syndrome. 38 adults will receive either the active drops or a steroid drop for 6 weeks. The study measures s…

This pilot study tests whether fecal microbiota transplantation (FMT) can improve moderate to severe hidradenitis suppurativa (HS), a painful skin condition. Researchers will give 24 adults a single FMT and track changes in their skin lesions over 12 weeks. The goal is to see if …

This study tests whether a 5-day course of inhaled amikacin can prevent ventilator-associated pneumonia in critically ill patients who already have a milder airway infection called tracheobronchitis. 250 adults on breathing machines will receive either the drug or a placebo. The …

This phase 2 trial tests whether dapagliflozin, a drug used for diabetes and heart failure, can reduce harmful antibodies and prevent relapses in people with membranous nephropathy, an autoimmune kidney disease. The study enrolls 20 adults who have had a recent rise in anti-PLA2R…

This pilot study will test whether supplements made from bilberries and olives can reduce inflammation and oxidative stress in people with prediabetes who are overweight. Researchers will collect blood, urine, and stool samples from 60 participants to measure changes in key healt…

This trial tests a one-time treatment called CAR-T cell therapy for people with systemic lupus erythematosus (lupus) that hasn't improved with standard medications. The therapy uses a patient's own immune cells, which are modified in a lab to find and destroy the B cells that dri…

This trial tests whether a procedure called EUS-guided gallbladder drainage can prevent future gallbladder attacks in people who are too sick or frail for surgery. Participants are randomly assigned to receive either the drainage procedure or standard medical care. The study will…

This study tests a new medicine called GR2301, given as shots under the skin, together with light therapy for people with vitiligo (a condition that causes white patches on the skin). The trial has two parts: first, finding the right dose, then testing how well it works. About 11…

This study will follow 220 patients with benign gallbladder diseases who cannot have surgery. It compares two non-surgical approaches: endoscopic drainage with possible stone removal versus traditional drainage alone. The goal is to see which method leads to fewer complications a…

This study tests whether a 3-day course of amoxicillin works as well as a 5-day course for children aged 3 months to 5 years with uncomplicated pneumonia. The goal is to see if shorter treatment can reduce side effects, lower costs, and fight antibiotic resistance. About 250 chil…

This study tests a new medicine called empasiprubart in teenagers aged 12 to 17 who have a rare nerve disease called CIDP. The goal is to find the right dose and see if the drug is safe and helps control the disease. Participants will receive the drug for about 27 months and be f…

This study tests whether a supervised resistance exercise program, done for 2 weeks before and 12 weeks after total hip replacement, improves muscle mass and strength in adults aged 60 and older with severe hip osteoarthritis. Participants are randomly assigned to either the exer…

This study tests whether adding a light-activated dye (photodynamic therapy) to standard deep cleaning improves gum disease more than cleaning alone. Thirty adults with periodontitis will have one side of their mouth treated with cleaning plus the dye/laser, and the other side wi…

This study tests a new nasal spray for adults with chronic sinusitis. The spray turns into a gel inside the nose and releases three active ingredients: stem cell exosomes to help repair the nasal lining, an antihistamine to reduce inflammation, and an antiviral agent. The goal is…

This study will test if taking oral azithromycin pills for three days each month works as well as getting a monthly penicillin shot to prevent rheumatic heart disease from getting worse. The trial plans to enroll 474 Nigerian secondary school students aged 10-18 with mild or mode…

This study tests a drug called teclistamab in 24 adults with a severe, rapidly worsening lung disease linked to anti-MDA5 antibodies. The disease has a very poor outlook, with only about 25% of patients surviving 90 days without a lung transplant. Teclistamab aims to improve surv…

This study tests whether an Ayurvedic treatment that targets digestion and gut health can reduce allergy symptoms and immune markers in people with allergic rhinitis (hay fever). 104 adults aged 18-40 with confirmed allergies will receive either the Ayurvedic treatment plus stand…

This study tests a treatment called extracorporeal photopheresis (ECP) for people with advanced melanoma who develop severe colitis or hepatitis from immunotherapy. ECP filters a patient's blood, treats it with a light-activated drug, and returns it to the body. The trial compare…

This study tests whether a new experimental effervescent tablet can clean removable partial dentures better than a commercial cleanser or water. Fifteen adults with denture stomatitis will wear dentures with small material discs to collect plaque, then soak them daily in one of t…

This early-phase study tests a new injectable drug called AHB-171 in 144 adults with chronic hepatitis B. The main goals are to check the drug's safety and how the body processes it. Some participants will also take standard oral antivirals. The study is not yet recruiting.

This study tests whether infusing fluid into the uterus during labor (amnioinfusion) can reduce brain injury in newborns whose mothers have a uterine infection called chorioamnionitis. The infection can cause inflammation and fever that may stress the baby's brain before birth. R…

This early study tests a new drug called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases, including lupus, multiple sclerosis, and rheumatoid arthritis. The main goal is to check safety and find the right dose. Participants receive the drug by injection, and resear…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

Researchers at Assiut University are testing whether a specialized MRI technique called multi-echo fast field echo (mFFE) can detect cortical bone changes in knee osteoarthritis as accurately as CT scans. The study enrolls 80 adults aged 40 and older with suspected or confirmed k…

Radiation pneumonitis is a lung inflammation that can appear weeks after radiotherapy for lung cancer, and patients may not link their symptoms to the earlier treatment. Researchers developed a smartphone app called PneumoCheck for patients to use at home, hoping it helps detect …

This study checks if a simpler way to collect blood samples works as well as the standard method for the HepQuant DuO liver test. The test involves drinking a natural substance and taking blood samples 20 and 60 minutes later. Researchers will compare different blood collection t…

Researchers are testing whether a smartphone app called DETECTRA can help doctors diagnose rheumatoid arthritis earlier in adults who have joint symptoms and a positive ACPA blood test. Participants are randomly assigned to receive standard care alone or standard care plus the ap…

Researchers at Turku University Hospital are testing a PET imaging tracer called Al[18F]F-NOTA-folate to see how well it detects two heart conditions: cardiac sarcoidosis, an inflammatory disease of the heart muscle, and infective endocarditis, an infection of the heart valves. T…

Researchers at the University of British Columbia are collecting intestinal ultrasound images from adults, including healthy people and those with inflammatory bowel disease such as Crohn disease or ulcerative colitis. The goal is to build a computer program that can measure bowe…

This study tests whether two simple blood markers, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), can signal inflammation caused by Helicobacter pylori infection in the stomach. Researchers will compare these ratios in adults with dyspepsia who h…

This observational study tests whether levels of MPO-DNA complexes in the blood can serve as a reliable biomarker for disease activity in systemic lupus erythematosus (SLE). Researchers will compare MPO-DNA levels in 90 participants with active versus inactive lupus, and check ho…

Peritoneal dialysis uses the belly lining as a natural filter for people with kidney failure, but over time this membrane can scar and stop working. This study tests whether levels of a protein called DKK3 in blood, urine, and dialysis fluid can serve as an early warning sign of …

This study investigates whether triphasic bone scans combined with SPECT/CT can accurately diagnose osteoarthritis in the foot and ankle, using MRI as the gold standard. Researchers will compare the imaging results from 40 adults with chronic foot or ankle pain to see how well th…

This study tests whether a newer ultrasound technique, shear wave elastography, can better detect inflammation at tendon and ligament attachment sites (entheses) in people with psoriatic arthritis compared to standard ultrasound. Researchers will compare imaging results from 60 p…

This study is testing whether a combination of simple, non-invasive tests—like a liver scan and blood samples—can accurately detect advanced liver fibrosis (scarring) in people at risk for fatty liver disease. Researchers will follow 1,200 adults aged 40 to 70 who have obesity, t…

This pilot study is testing whether a rapid, point-of-care blood test can help identify early signs of infection and sepsis in preterm infants. Researchers will measure inflammatory markers like IL-6, PCT, CRP, and MxA in blood samples from about 40 to 80 premature babies, compar…

This study looks at whether two simple calculations, called Cancer Ratio and Cancer Ratio Plus, can help doctors tell the difference between fluid around the lungs caused by cancer and fluid caused by tuberculosis. These calculations use results from routine blood and fluid tests…

This study tests whether two advanced MRI techniques, called Double Inversion Recovery (DIR) and Diffusion Tensor Imaging (DTI), can improve the assessment of optic neuritis—inflammation of the optic nerve that can affect vision. Researchers will compare MRI measurements of the a…

This study tests whether combining two stool tests—fecal immunochemical test (FIT) and fecal calprotectin (FC)—can accurately detect precancerous or cancerous changes in people with long-standing ulcerative colitis. Participants will provide stool samples and then undergo a speci…

This study tests whether an AI-powered digital stethoscope can help health workers more accurately diagnose pneumonia in children aged 2 months to 5 years. 350 children with cough or breathing difficulty will be randomly assigned to standard care or care plus the AI stethoscope. …

This study tests a special imaging agent (99mTc-NTP 15-5) to see if it can spot arthritis-damaged joints in the hands and tell the difference between osteoarthritis and rheumatoid arthritis. About 80 adults with one of these conditions will get a scan. The goal is to improve diag…

This study tests a special capsule that patients swallow to check if their intestines are clear enough for a standard camera capsule. About 25 people with known or suspected intestinal narrowing will take part. They will swallow the patency capsule and get an X-ray within 30 hour…

This study looks at whether a substance in urine, called PGE-MUM, can show if ulcerative colitis is active or in remission. Researchers will collect urine and blood samples from 114 adults with confirmed ulcerative colitis and compare the results with colonoscopy findings. If suc…

This study will test a new type of PET/CT scanner, called Long-Axial Field-of-View (LAFOV), to see if it can provide clearer images of blood vessel inflammation in people with large vessel vasculitis (LVV). The scanner is more sensitive and can image the whole body faster, potent…

This study tests whether AI-powered decision trees can help general practitioners better diagnose and manage allergies. About 600 patients with suspected allergies will be enrolled, and doctors will use an app that suggests next steps based on symptoms. The goal is to see if this…

This study tests whether an AI tool called RADAR can help nurses in low-resource settings detect rheumatic heart disease more accurately using echocardiography. The goal is to make screening easier to scale up worldwide. The trial will enroll 62 nurse screeners at participating f…

Pancreatitis is a painful inflammation of the pancreas that can happen after an ERCP procedure. Doctors often give rectal indomethacin around the time of ERCP to lower that risk, but it still occurs. This trial randomly assigns adults having ERCP to receive either rectal indometh…

This study will test whether a single antibiotic injection given during cataract surgery can prevent endophthalmitis, a rare but severe eye infection. About 60,000 people with cataracts will receive either the antibiotic or a placebo. The goal is to see if the antibiotic reduces …

Researchers are studying whether aloe vera mouthwash can prevent or reduce the severity of oral mucositis, a painful mouth sore that often affects people receiving chemotherapy for acute leukemia. The trial compares aloe vera mouthwash plus usual care against usual care alone in …

Children who receive hematopoietic stem cell transplants often develop painful mouth sores called oral mucositis, which can lead to poor eating, infection, and longer hospital stays. This trial tests whether a structured oral care program, including caregiver education, supervise…

This trial tests whether training nursing home staff to provide better oral hygiene can reduce pneumonia in residents aged 60 and older. Participants will use special toothpastes and mouthwashes, including stannous fluoride and chlorhexidine options. The study measures how many r…

This trial tests whether giving children aged 5 to 8 a twice-daily penicillin pill can prevent rheumatic heart disease, a serious condition that can damage heart valves. Researchers will compare children who take the antibiotic with those who do not, following them for three year…

This trial tests whether a self-administered vaginal swab, analyzed with advanced molecular technology, can detect and treat bacterial imbalances early in pregnancy. Pregnant women at high risk of preterm birth will either receive this screening plus targeted antibiotics or stand…

This trial tests whether a daily supplement called Immune X can help prevent common colds in healthy adults who often get upper respiratory infections. Over 16 weeks during winter, participants take either Immune X or a placebo and track any cold symptoms. The study compares how …

This trial tests whether a short, purpose-built educational video can strengthen high-school students' belief in disaster preparedness and their perception of disaster risk. About 144 students from twelve classes at one school in West Kalimantan, Indonesia, will be randomly assig…

This trial tests whether a single intravenous dose of tacrolimus, given just before an ERCP procedure, can lower the chance of developing post-ERCP pancreatitis (PEP) in adults at moderate-to-high risk. Participants receive either tacrolimus or a placebo infusion, along with stan…

This trial tests whether applying 5-ASA (mesalamine) directly to the ileal pouch after surgery for ulcerative colitis can prevent pouchitis—a painful inflammation that affects more than half of patients. Adults with UC who are scheduled for pouch surgery are randomly assigned to …

This study tests whether a special combination of supplements (sodium nucleinate, magnesium, vitamin B6, and high-dose vitamin D) can prevent respiratory infections like colds and flu better than standard multivitamins. Two hundred healthy male military recruits in Kazakhstan wil…

This pilot study tests two light therapy devices—one placed inside the mouth and one outside—to prevent and treat painful mouth sores caused by radiation therapy. Sixty adults with oral cavity or oropharynx cancer will receive light sessions twice a week for prevention, then thre…

This study tests whether a lower dose of the antibiotic TMP-SMX works as well as the standard dose to prevent a serious lung infection called PJP in people who have just had a kidney transplant. About 1,084 adult first-time kidney transplant recipients will take either a low or s…

This study tests whether semaglutide (Ozempic/Wegovy) can prevent repeat episodes of acute pancreatitis caused by very high triglycerides. About 396 adults who recently had such an attack will receive either semaglutide injections or a placebo for 18 months, alongside standard ca…

Researchers are testing an experimental oral drug called soquelitinib in adults with moderate-to-severe hidradenitis suppurativa, a chronic skin condition that causes painful lumps and tunnels. The trial aims to see if the drug is safe and can reduce the number of inflammatory le…

Researchers are comparing two forms of shockwave therapy, focused and radial, for adults with chronic plantar fasciitis, a common cause of heel pain. About 150 participants receive three weekly treatment sessions and then answer questions about pain and foot function for up to a …

This study tests whether a full-spectrum screen bar light can reduce eye fatigue and dry eye symptoms after two hours of computer work. Healthy adults aged 18 to 35 who use screens at least four hours daily will be randomly assigned to use the light or a standard screen without i…

Researchers are testing whether intermittent fasting improves quality of life for adults with acute or chronic pancreatitis. Participants follow a daily 16-hour fast or receive standard calorie guidance. The study measures pancreas-related quality of life, pain, opioid use, weigh…

Researchers are testing whether tranexamic acid, a drug that helps prevent bleeding, reduces blood loss and wound complications during high tibial osteotomy. This surgery realigns bow-legged knees to ease osteoarthritis pain and slow joint damage. The trial enrolls 200 adults wit…

Plantar fasciitis causes heel pain when the tissue supporting the foot arch degenerates. Standard treatments like physical therapy, anti-inflammatory drugs, and orthotics help most people, but some continue to have pain for months. Researchers are testing three ultrasound-guided …

Researchers compare two surgical methods for removing an inflamed appendix in obese patients: laparoscopic (keyhole) surgery and traditional open surgery. The trial enrolls 166 obese adults with acute appendicitis, randomly assigning each to one of the two procedures. The main go…

Researchers are testing a gel made from orange peel extract to see if it can reduce the severity of mouth sores caused by radiation therapy in people with head and neck cancer. Thirty adults receiving radiation will be split into two groups: one gets the orange peel gel, the othe…

Researchers compare two ways to perform knee surgery for simple problems like meniscal tears, cartilage damage, and loose bodies. One method uses a needle arthroscopy with a 1.9mm camera through tiny openings, and the other uses standard arthroscopy. Adults aged 18 to 65 join the…

This study compares two ways to give steroid medicine to people with chronic sinusitis who have lost their sense of smell due to blocked nasal passages. One group will get standard steroid spray, while the other gets steroid drops placed directly where smell happens. The goal is …

This study looks at ways to reduce pain during knee steroid injections for osteoarthritis. Researchers will test if using a thinner needle or a numbing spray (ethyl chloride) makes the injection hurt less. 88 adults with knee osteoarthritis will rate their pain right after the sh…

Researchers are testing whether a single injection of a hyaluronic acid solution into the knee can reduce pain and improve stiffness and function in people with knee osteoarthritis. The trial enrolls about 700 adults aged 40 to 80 who have had knee osteoarthritis symptoms for at …

Researchers want to see whether facial photographs can show how well a fluticasone propionate nasal spray eases facial allergy symptoms. The study enrolls 16 adults with moderate to severe seasonal allergic rhinitis. Participants use the nasal spray and have their faces photograp…

Researchers are asking people with psoriasis to use Doublebase Once, a once-daily leave-on emollient, as their only moisturizer for about one month. Up to 100 adults across the UK join from home and answer online questionnaires about their skin and how the product feels to use. T…

This study compares two doses of the antibiotic ceftriaxone for adults hospitalized with pneumonia (but not in the ICU). The goal is to see if a 1-gram daily dose works just as well as a 2-gram daily dose while causing fewer side effects. About 430 participants will be followed t…

This study tests a mobile app designed to help Black and Hispanic adults with inflammatory bowel disease (IBD) manage stress and improve their quality of life. The app teaches coping skills, mindfulness, and disease acceptance. Researchers want to see if the app is practical and …

This trial tests whether a personalized 6-month exercise program can reduce persistent fatigue in people with inflammatory bowel disease (IBD) who are in remission. Researchers will randomly assign 120 participants to either the exercise program or usual care. Fatigue levels are …

This study looks at whether using different root canal tools (TruNatomy vs ProTaper Gold) and different sealers (AH Plus vs TotalFill BC) can reduce pain after a root canal. About 144 adults with a tooth infection will take part. They will rate their pain at several times over a …

Researchers at Mayo Clinic are running a pilot study to see whether clearing a blocked pancreatic duct improves how the pancreas makes insulin in people with chronic pancreatitis. Participants are adults with minimally symptomatic chronic pancreatitis and a duct blockage. The stu…

Researchers are testing whether a wrist nerve block, which uses a local steroid injection to interrupt pain signals, can reduce wrist pain in adults with rheumatoid arthritis. The trial enrolls 180 people with oligoarticular rheumatoid arthritis that affects the wrist. Participan…

Researchers are testing whether EEG brain wave patterns can track how the sedative dexmedetomidine eases pain during total hip replacement surgery. Twenty patients with hip osteoarthritis receive a dexmedetomidine infusion before their spinal anesthesia. The team records brain ac…

Researchers are testing an experimental biologic drug called PRA-216 in adults with moderate to severe atopic dermatitis, a form of eczema. The trial compares PRA-216 with a placebo to see whether the drug is safe and can reduce eczema severity. Participants must have had eczema …

Dry eye can appear or worsen after cataract surgery, causing discomfort and blurry vision. Researchers at the Medical University of Vienna are testing whether a hyaluronic acid gel placed into the tear drainage duct of one eye can help retain tears and reduce dry eye. Each partic…

This study tests whether an 8-week mindfulness-based stress reduction (MBSR) program can lower stress and improve well-being in people with inflammatory bowel disease (IBD). Seventy adults with mild-to-moderate IBD will either take the MBSR course online or watch an educational s…

This trial tests whether adding a nerve block at the back of the knee to the standard adductor canal block reduces pain and opioid use after total knee replacement. Adults scheduled for knee replacement under spinal anesthesia will receive either the standard block alone or the s…

This trial tests whether a home-based strength training program combined with self-management education can reduce symptoms and improve quality of life for people with knee osteoarthritis. Participants aged 45 and older are randomly assigned to either the exercise and education p…

This study tests whether a daily CBD cream can provide quick and lasting pain relief for people with plantar fasciitis, a common cause of heel pain. Fifty adults with the condition will apply either the CBD cream or a placebo for one month. Researchers will measure pain changes r…

This Phase 2 study tests lebrikizumab (Ebglyss) in 15 adults with moderate-to-severe prurigo nodularis, a skin condition causing intense itching and hard bumps. Participants receive injections every two weeks for 24 weeks. The main goals are to measure how much itching decreases …

This trial tests whether colchicine, an anti-inflammatory drug used for gout, can reduce pain after total knee replacement surgery. Adults having knee replacement for osteoarthritis will take colchicine or a placebo for a few days after surgery. Researchers will track pain scores…

This trial tests whether adding pulsed electromagnetic field therapy (PEMF) to standard shock wave therapy eases pain and improves function in adults with tennis elbow, a condition causing pain on the outer side of the elbow. About 70 people with symptoms lasting at least 3 month…

This pilot study tests whether a 16-week Mediterranean-style diet program is practical and acceptable for adults with hidradenitis suppurativa, a chronic skin condition. All 30 participants receive the same program, which includes video counseling, cooking education, and food sup…

This trial tests whether two different collagen supplements can reduce pain, stiffness, and disability in adults with knee osteoarthritis. Adults aged 35 to 65 with moderate knee osteoarthritis will take either a 10-gram hydrolyzed collagen, a 5-gram bioactive collagen peptide, o…

Researchers are testing whether a daily drink containing hyaluronic acid can ease knee pain and improve joint function in adults aged 45 to 80 with mild knee osteoarthritis. Participants will drink either the active beverage or a placebo each day and report their pain levels usin…

This trial tests whether an 8-day mindfulness body scan can reduce stress, anxiety, and depression in adults who survived tidal flooding in Sayung, Demak, Indonesia. Participants will practice guided body scan meditation and have their blood tested for inflammation markers before…

This trial tests whether an 8-day mindfulness body scan can reduce stress and inflammation in people who have survived repeated tidal flooding. Researchers will measure blood markers like IL-6, TNF-α, CRP, and cortisol, along with questionnaires on depression, anxiety, sleep, and…

This study tests whether a 10-session virtual group psychotherapy program can help people with inflammatory bowel disease (IBD) who also have anxiety or depression. The therapy is adapted from a standard manual called Mind Over Mood and includes education on the brain-gut connect…

This study tests a physical therapy program designed for older adults with knee osteoarthritis. The program focuses on mobility, balance, and fall prevention, and also considers each person's mental abilities. Forty participants aged 60 and older will take part in 16 sessions ove…

This trial investigates whether a single injection of dexamethasone, a steroid, given before a root canal can lower pain during the procedure. It includes adults with severe tooth pain from symptomatic irreversible pulpitis. Participants receive either dexamethasone or a placebo,…

This trial tests different concentrations of an experimental eye drop called BL1107 to find the lowest dose that completely clears eye redness (conjunctival hyperemia) in people with dry eye disease. About 20 participants with dry eye and redness in both eyes will receive the eye…

This trial tests whether a structured art therapy program, grounded in positive psychology, can improve self-compassion and hope in children aged 8 to 12 who are staying in a hospital ward. Half of the 80 participants will receive the art therapy sessions alongside standard nursi…

This study tests whether textured shoe insoles can improve balance, walking, and foot sensation in adults with plantar fasciopathy, a common cause of heel pain. Participants will wear both textured and smooth insoles while researchers measure their postural control, gait, and pla…

This trial tests whether duloxetine, an FDA-approved osteoarthritis drug, can improve walking ability and physical activity in people with chronic knee osteoarthritis pain. Participants take duloxetine or a placebo for six weeks, then complete surveys, physical tasks, brain imagi…

This trial tests whether Yanlishuang buccal dropping pills, a traditional Miao medicine, can relieve the sore throat and pain of acute pharyngitis. About 400 adults with a sore throat that started within the last 48 hours will be randomly assigned to take either the herbal drops …

This trial tests whether flushing the inside of a tooth with cold saline (about 2.5°C) after root canal retreatment can lower pain and inflammation. One hundred adults needing retreatment on a lower premolar will be randomly assigned to receive either cold or room-temperature sal…

This pilot trial tests whether a web-based conversational assistant can help people recovering from total knee replacement. About 60 adults who have had knee replacement surgery will either receive standard care alone or standard care plus access to the online assistant for 6 wee…

This trial compares two simple treatments—sucking on ice chips or using a lidocaine spray—to see which better prevents or reduces painful mouth sores caused by chemotherapy. About 60 adults with cancer who are about to receive chemotherapy will be randomly assigned to one of the …

This study tests whether injecting botulinum toxin (Botox) into the hands or feet can help people with Buerger's disease, a rare condition that blocks blood flow and causes severe pain. Eight adults with critical limb ischemia will receive a single injection session and be follow…

This trial tests whether adding a hands-on technique called manual traction to standard physical therapy can reduce pain and improve function in women recovering from total knee replacement. Forty-eight women aged 50 to 75 with knee osteoarthritis will be randomly assigned to rec…

This study tests whether a thoracic epidural block—a numbing injection near the spine—can help people with severe acute pancreatitis avoid or shorten the need for intensive care support like breathing machines and kidney dialysis. Participants are randomly assigned to receive eit…

This study tests whether applying citric acid during a procedure to remove dark gum pigmentation leads to better-looking results and faster healing. Adults aged 18 to 50 with natural dark gums will receive either standard depigmentation or depigmentation plus acid. The researcher…

This study tests whether using a virtual reality (VR) headset during hip replacement surgery can lower anxiety and prevent post-surgery confusion in older adults. Half of the participants will watch calming nature scenes through VR while under regional anesthesia, while the other…

This trial tests whether an injection of tergase (berahyaluronidase alfa) can reduce swelling after total knee replacement surgery. The study involves 30 older adults with severe knee osteoarthritis who are having both knees replaced at the same time. One knee receives the inject…

This study tests whether a 3% hypertonic saline (saltwater) rinse, used at the end of a root canal procedure, can reduce pain and inflammation better than the standard 0.9% saline rinse. Forty adults with painful tooth inflammation will receive one of the two rinses, and their pa…

This trial tests F-GYN, a single-use injectable gel made of non-crosslinked hyaluronic acid, for women with moderate to severe vaginal dryness and atrophy. Participants either receive the injection right away or continue standard non-hormonal care for 4 weeks before getting the i…

This study tests whether a short, digitally guided exercise program before total knee replacement is practical and helpful. Sixty adults with knee osteoarthritis will either do the 10-14 day program or receive usual care. The main goal is to see if people stick with it and find i…

This trial compares two approaches for adults with interstitial cystitis, a condition causing long-term bladder pain and frequent urination. All participants receive education and behavioral training, while half also take the antidepressant venlafaxine for 12 weeks. Researchers w…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

Cellulitis is a painful bacterial skin infection. This study tests whether adding naproxen (an anti-inflammatory drug) to standard antibiotics helps reduce redness and pain faster than antibiotics alone. About 884 adults with cellulitis will take either naproxen or a placebo for …

This study tests whether using very cold water (around 2-3°C) to rinse the inside of a tooth during a root canal can lower pain afterward. The trial includes adults aged 20-40 with painful, infected lower molars. Participants are randomly assigned to receive either cold rinses th…

This pilot study tests whether injecting hyaluronic acid directly into the bladder wall is safe and can reduce pain and frequent urination in people with interstitial cystitis (bladder pain syndrome). Fifteen adults who haven't improved after standard treatments will receive the …

This study will test whether an 8-week yoga program done live over Zoom can improve balance, endurance, and well-being in 32 children aged 8-12 with juvenile idiopathic arthritis (JIA). The yoga sessions are led by certified physiotherapists and include breathing, poses, and medi…

This study compares two non-surgical treatments—shockwave therapy and high-power laser—for chronic tennis elbow (lateral epicondylitis) that has lasted over 3 months. Seventy-two adults aged 40-50 will receive one of the treatments plus standard physical therapy. Researchers will…

This study will compare two types of nerve mobilization added to standard physical therapy for chronic plantar fasciitis. Sixty adults with heel pain for at least six weeks will be randomly assigned to receive either posterior tibial nerve mobilization or saphenous nerve mobiliza…

This study tests whether a special yogurt containing the probiotic Pediococcus acidilactici GR-5 can help people with chronic cholecystitis (long-term gallbladder inflammation). Fifty adults with the condition will eat either the probiotic yogurt or a regular placebo yogurt daily…

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This Phase 3 trial tests whether CAM-101 eye drops can reduce eye discomfort and corneal damage in people with moderate to severe dry eye. About 475 adults will receive either CAM-101 or a placebo for 9 weeks, then all participants can switch to CAM-101 for a year. The study aims…

This study tests a new herbal blend designed to shorten the duration and reduce the severity of common cold symptoms. Researchers will enroll 300 healthy adults in Australia who get frequent colds. Participants will take the herbal product or a placebo whenever they feel a cold c…

This study tests whether a short liquid diet followed by a low-sulfur eating plan is safe and helpful for people with mild to moderate ulcerative colitis. Researchers will check if this approach improves gut health, lowers inflammation, and eases symptoms. They will also use brea…

This study tests whether adding a pill called pentoxifylline to standard skin creams can improve mild-to-moderate psoriasis. About 140 adults will take either the study drug or a placebo twice daily for 12 weeks. Researchers will measure changes in skin severity, itch, and qualit…

This study tests whether isotretinoin or doxycycline works better for treating an acne-like rash that can appear in people taking certain cancer drugs. About 50 participants who already have a moderate to severe rash will receive one of the two medications. The goal is to see whi…

This study compares two spinal anesthetics, ropivacaine and bupivacaine, in 176 people having hip replacement surgery. The goal is to see which one allows faster return of feeling and movement while still controlling pain well enough for same-day discharge.

This study looks at how well and how safely SIROPSEDAL syrup works for acute cough caused by colds or upper respiratory infections. About 124 children and adults will take the syrup as prescribed by their doctor and report their cough severity over one week. The main goal is to s…

This study compares two strengths of sodium hypochlorite (a disinfectant used during root canals) to see which causes less pain afterward. 116 adults needing a root canal will be randomly assigned to receive either a 2.5% or 5.25% solution. Pain levels will be measured at 6, 12, …

This study looks at how well RHINOSEDAL works for people aged 8 and older with a stuffy nose caused by colds, allergies, or sinus issues. About 126 participants will use the treatment as prescribed and report their symptoms over 6 days. The goal is to see if it provides meaningfu…

This study tests whether a roller device that delivers essential oils during self-massage can reduce pain and improve function in people with chronic tennis elbow (lasting over 3 months). Eighty adults will use the roller twice daily for 3 months. Researchers will measure pain an…

This early study tests the safety of a single injection of a new polymer called ABR1 for knee osteoarthritis. About 25 adults with moderate to severe knee pain will receive the injection and be followed for 12 weeks. The main goal is to see if the treatment causes any side effect…

This study looks at whether using a gentle pulling force (mechanical traction) on the knee before or after exercise works better for easing pain and improving movement in people with knee osteoarthritis. Researchers will compare three groups: traction before exercise, traction af…

This study looks at whether changing body position and doing special breathing exercises can help prevent lung issues like pneumonia after heart surgery. About 124 adults having planned heart surgery will be split into four groups: one getting usual care, one doing only breathing…

This study looks at whether adding kinesiotaping (a special elastic tape) to standard physical therapy can improve pain, movement, and fear of activity in people with knee osteoarthritis. Sixty adults aged 40-65 with mild knee arthritis will be randomly assigned to receive either…

This study tests a new online program called TEAM-LEADS designed to help teens and young adults (ages 13-22) with lupus or dermatomyositis reduce stress and improve heart-healthy behaviors like diet, exercise, and sleep. The program is self-guided and completed online. The study …

This study tests a painless light treatment called photobiomodulation for children aged 3 to 14 who get severe mouth sores from chemotherapy. The treatment uses a handheld red light device for about 5-10 minutes daily for four days, alongside standard care. Researchers want to se…

This study compares two tonsil surgery methods in adults: full removal (extracapsular) and partial removal (intracapsular). The goal is to see if partial surgery allows a shorter sick leave and less need for opioid painkillers, while still being as effective at relieving tonsilli…

This study tests whether a daily lutein supplement made from microalgae can slow cognitive decline in postmenopausal women with obesity. 300 women aged 48-60 will take either 6 mg, 14 mg, or a placebo for 180 days. Researchers will measure changes in memory, attention, and inflam…

This study will test whether high-intensity laser therapy, added to standard physiotherapy, can increase knee cartilage thickness and reduce pain in people with knee osteoarthritis. About 58 adults aged 40-60 with moderate knee OA will receive either laser plus physiotherapy or p…

Researchers are observing 300 adults aged 60 and older with inflammatory bowel disease who are starting an advanced therapy chosen by their usual care team. The study tracks immune-aging markers such as CD4/CD8 ratio and IL-6, along with frailty and nutrition, over 52 weeks. The …

This study will follow 100 adults with Crohn's disease, ulcerative colitis, or other IBD, plus their healthy relatives, for up to 3 years. Researchers will collect blood, stool, tissue samples, and imaging to track how immune cells and genetics change over time. The goal is to fi…

Autoimmune hepatitis makes a child's immune system attack their liver. Researchers at Assiut University Children's Hospital want to know how many children with this liver condition also develop thyroid disorders such as Hashimoto thyroiditis or Graves' disease. The team will test…

Researchers are testing whether blocking three inflammation pathways at once (TL1A, IL-23, and α4β7) calms inflamed intestinal tissue more effectively than blocking each pathway alone. The study enrolls 30 people: 10 with ulcerative colitis, 10 with Crohn's disease, and 10 withou…

This pilot study looks at whether it is safe to stop giving antibiotics after surgery for a burst (perforated) appendix. About 100 adults will be randomly assigned to receive either antibiotics or no antibiotics after their operation. The main goal is to see if a larger study is …

People with rheumatic heart disease and atrial fibrillation take warfarin to prevent strokes, but the drug only works safely when blood clotting stays in a narrow target range. Researchers at Assiut University are studying about 90 Egyptian adults on warfarin for at least six mon…

Many older adults with knee osteoarthritis believe their pain comes mainly from joint wear and tear, which can lead to fear of movement and less activity. Researchers at McMaster University are comparing two web-based education programs: one that explains pain as a mix of biologi…

Researchers at the University of Reading are studying how sleep and pain relate in adults with hip or knee osteoarthritis. Participants wear a wrist sleep monitor for seven days and nights while answering daily questions about sleep, pain, and mood. The team compares reported sle…

This study looks at how anxiety, depression, and stress might cause advanced IBD treatments to stop working. Researchers will ask 450 people with IBD to fill out questionnaires about their mental health while they receive regular infusions. The goal is to understand if mental hea…

This study creates a UK-wide registry for people with vitiligo, a skin condition causing white patches. It will track the safety and effectiveness of current treatments in up to 30 patients. The goal is to improve long-term care by collecting real-world data from dermatologists.

Researchers are studying where the bacteria that infect skin sores come from in people with scabies or atopic dermatitis. They will compare bacteria grown from infected skin lesions with bacteria from nasal swabs to see if the same species appear in both places. A group of health…

This study looks at three different ways to clean infected root canals in 66 men aged 18-35. The goal is to see which method best reduces signs of inflammation and infection. Researchers will measure certain proteins in the fluid around the tooth root before and after treatment.

Researchers at Assiut University Children Hospital are comparing conventional and biologic therapies in children and adolescents with inflammatory bowel disease, including Crohn's disease and ulcerative colitis. The study tracks about 100 patients to measure clinical remission at…

Researchers are comparing two common types of total shoulder replacement, anatomic and reverse, in adults who already had the surgery. The study tracks patient-reported pain and function scores, complications, and revision surgeries for three years. They also check how often the …

Researchers at Sohag University are following 50 children under 18 who have systemic juvenile idiopathic arthritis, a rare inflammatory disease that affects the whole body. The study records each child's symptoms, lab results, complications, and the treatments they receive, inclu…

This study looks closely at children admitted to a hospital with acute flaccid paralysis, a condition causing sudden muscle weakness or paralysis. Researchers will collect information from routine medical care to describe the clinical features, possible risk factors, and outcomes…

This study is exploring whether a rapid, non-invasive stool test can help monitor inflammatory bowel disease (IBD) in children. The test uses a technology called differential mobility spectrometry (DMS) to analyze the molecular profile of stool samples. Researchers will compare t…

This observational study aims to collect and analyze data from up to two million patients with dermatologic conditions like vitiligo, atopic dermatitis, alopecia areata, and hidradenitis suppurativa, as well as their healthcare providers. By reviewing treatment patterns, outcomes…

Some people with inflammatory bowel disease who take anti-TNF drugs develop painful rashes in skin folds and around the mouth, a condition called SPIDER. Researchers at a French hospital are studying whether levels of Staphylococcus aureus bacteria in these rashes change over six…

Researchers at the University of Copenhagen are studying why some people with newly diagnosed Graves' disease develop thyroid eye disease while others do not. The study follows about 430 participants for one year, collecting eye exams, blood and tear samples, and symptom question…

Membranous nephropathy is a rare autoimmune kidney disease where antibodies attack the kidney and can cause nephrotic syndrome. Rituximab is a routine treatment that depletes B cells, but researchers suspect it also boosts regulatory T cells, which help control immune reactions. …

Researchers are testing whether people with rheumatoid arthritis have early, symptom-free kidney problems more often than healthy people of the same age and sex. The study compares kidney function and urine protein levels between 120 participants, including those with rheumatoid …

Researchers at Assiut University are studying whether rheumatic diseases such as rheumatoid arthritis, lupus, and Sjogren's syndrome harm the meibomian glands, the tiny eyelid glands that keep tears from evaporating. The study compares 120 people with these conditions to 30 healt…

Laparoscopic fundoplication relieves reflux for most GERD patients, but 10 to 30 percent still have symptoms or side effects afterward. Researchers at Minia University Hospitals follow 470 adults scheduled for this keyhole surgery, measuring ten factors before the operation such …

This study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…

This study follows adults hospitalized with a lower respiratory tract infection, such as pneumonia or bronchitis, to measure how their quality of life changes over one year. Researchers use a standard questionnaire to track physical, mental, and social well-being at several point…

Researchers are testing a visual sampling capsule that collects fluid from different parts of the intestine without surgery. They will use it in 250 people, including those with active or remission Crohn's disease or ulcerative colitis, plus healthy volunteers. By analyzing the m…

This study builds a long-term research cohort for people with psoriasis, eczema, or hidradenitis suppurativa. Participants use a certified app to answer symptom questions and take standardized photos of their skin once a month, with longer questionnaires twice a year. Trained ass…

This registry study collects real-world data from about 300 adults treated with urinary bladder matrix (UBM) products for various wounds, including pressure ulcers, surgical incisions, and infections like Fournier's gangrene. Researchers track patient characteristics, treatment p…

This observational study will use advanced imaging techniques to measure changes in the retina and choroid (the layer beneath the retina) in people with eye diseases and healthy volunteers. Over 5 years, researchers will track thickness and blood vessel density to better understa…

Researchers at Sohag University are studying 150 people with rheumatoid arthritis to see whether the Rheumatoid Arthritis Impact of Disease (RAID) questionnaire can reliably detect disease flares. They will compare the questionnaire's performance with other standard disease activ…

Researchers at Queen's University are testing a method to safely trigger eye allergies in a research setting. They will apply timothy grass extract to the eyes of allergic and non-allergic volunteers, then measure symptoms and collect tear and nasal fluid samples. The goal is to …

This study looks at how gum inflammation and the bacteria in your mouth interact with your body's immune system. Twenty healthy adults will use a special toothpaste and then stop brushing for a period to see how inflammation and bacteria change. The goal is to better understand t…

This study examines children aged 1 to 18 with tinea capitis, a common fungal infection of the scalp. Researchers will use clinical exams, dermoscopy, and laboratory tests to describe the infection's patterns and identify the specific fungi causing it. The goal is to improve unde…

This study looks back at medical records from high-volume hospitals in Russia and China to compare how patients with stomach cancer or cancer at the junction of the stomach and esophagus fare after a specific surgery called proximal gastrectomy with double-tract reconstruction. R…

This study investigates whether the bacteria living in the gut influence the development of diverticular disease and acute diverticulitis. Researchers will compare the gut microbiota of people with and without these conditions to identify differences and risk factors. The goal is…

This study is testing whether a prediction model can accurately forecast how quickly kidney function declines in people with primary membranous nephropathy, a kidney disease that can lead to nephrotic syndrome and kidney failure. Researchers will follow 128 adults with biopsy-con…

This study looks at adults with ringworm infections that resist standard antifungal treatment. Researchers will scrape the edge of the skin lesions and examine the samples under a microscope and in the lab to identify the fungus and test which antifungals might work. The goal is …

Researchers at Sohag University are comparing levels of a long non-coding RNA called GAS5 and a blood protein called IL-6 in people with rheumatoid arthritis versus healthy individuals. The study will measure GAS5 expression in blood samples using a technique called qRT-PCR and c…

Researchers at Assiut University are studying how nutrition, diet-related inflammation, and blood markers relate to disease activity in people with inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. The study will enroll 100 adults aged 18 to…

This study looks at whether routine blood test results can help predict which patients with acute pancreatitis will develop severe disease or die within 28 days. Researchers will track 109 adults admitted with acute pancreatitis and compare their blood cell ratios, such as neutro…

This study looks at whether a blood protein called asprosin is linked to metabolic syndrome and heart risk in people with rheumatoid arthritis. Researchers will compare asprosin levels in three groups: rheumatoid arthritis patients with metabolic syndrome, those without it, and h…

Researchers at Assiut University are studying how psoriatic arthritis affects patients' daily lives and whether that impact matches clinical signs of disease activity. Adults with psoriatic arthritis will complete the Arabic version of the PsAID-12 questionnaire, which covers pai…

Researchers at National Taiwan University Hospital are looking back at records of adults who came to the emergency department with right-sided belly pain and were diagnosed with either epiploic appendagitis or diverticulitis. They will compare symptoms, lab results, and CT and ul…

Researchers are measuring how often subclinical hypothyroidism, a mild form of underactive thyroid, occurs in people with rheumatoid arthritis compared to healthy people. They will also check whether this thyroid condition relates to higher disease activity or more severe joint i…

This study follows 7,500 children aged 5 to 8 who live in areas where rheumatic heart disease is common. Each child gets a heart ultrasound once a year for three years to check for early signs of the disease. Researchers will count how many children develop rheumatic heart diseas…

This study explores whether providing home self-sampling kits for six sexually transmitted infections (STIs) can help sex workers get tested more easily. Participants receive a kit to collect samples at home and return them by mail, along with a questionnaire about their backgrou…

This study is a large registry that will collect detailed information from thousands of women undergoing surgery for non-cancerous gynecologic conditions like fibroids, endometriosis, and ovarian cysts. The goal is to track surgical techniques, complications, and recovery in real…

This observational study will follow 1,500 adults with chronic pancreatitis for several years, collecting health data and biological samples like blood, stool, and bile. The goal is to track how the disease changes over time, especially in those undergoing ERCP treatment, and to …

This observational study aims to map the immune and molecular profiles of people with inflammatory skin conditions, including genetic forms like epidermolysis bullosa. By comparing these profiles to those of healthy individuals, researchers hope to identify unique signatures that…

This study is a large international registry that will look back at the medical records of about 1,000 adults who were treated with the AngioVac system, a device that uses suction to remove blood clots, infected tissue, or other unwanted material from the heart and major blood ve…

This study looks at whether a structured surveillance program using regular ultrasound and a blood test (alpha-fetoprotein) can detect liver cancer at an earlier, more treatable stage in people at high risk. About 300 adults with liver cirrhosis, chronic hepatitis B, or advanced …

This study investigates whether the thickness of fat over the shin bone, measured on a standard knee X-ray, is a better predictor of infection after total knee replacement than Body Mass Index (BMI). Researchers will review data from 400 adults who had knee replacement surgery, c…

This study looks at how bariatric surgery affects the liver's energy processing in people with obesity and fatty liver disease. Researchers will use safe, non-radioactive tracer infusions and MRI scans before, during, and six months after surgery to measure changes in liver metab…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study looks at whether levels of a protein called 15-PGDH in the blood and joint fluid are linked to the severity of osteoarthritis and ankylosing spondylitis. Researchers will measure 15-PGDH in about 51 adults with these conditions and compare it with ultrasound images and…

This study will test whether common orthopedic materials, like titanium alloy and polylactic acid (PLA), are safe for use in knee surgery. Researchers will expose human tissue samples from 50 knee replacement patients to these materials in the lab. They will check for cell damage…

This study investigates why children with inflammatory bowel disease (IBD) have an overactive immune response in the gut, and whether blood stem cells can be engineered to restore tolerance. Researchers will analyze blood and intestinal tissue samples from 80 children with IBD, w…

This observational study looks at whether the total antioxidant capacity of a person's diet is linked to levels of inflammation and nutritional health in adults with type 2 diabetes. Researchers will compare people with well-controlled blood sugar to those with poorly controlled …

This observational study follows adults in France who are newly diagnosed with chronic hepatitis B (with or without hepatitis D). Researchers will measure liver scarring, treatment eligibility, and viral characteristics to understand how severe the disease is at diagnosis. The go…

This study investigates what factors — such as pain intensity, fear of movement, and confidence in managing pain — influence how adults with chronic tennis elbow perceive their illness and what they expect from treatment. Researchers will survey 137 participants and analyze the d…

This study uses web-based interviews to explore how adults in Japan with pulmonary fibrosis decide whether to continue or stop antifibrotic therapy after experiencing side effects. Researchers aim to understand the personal and psychological factors behind these decisions. The fi…

This study is testing whether an integrated precision medicine platform can improve how doctors diagnose and manage chronic inflammatory lung diseases like COPD and idiopathic pulmonary fibrosis. Researchers will collect blood and saliva samples for biomarker analysis, monitor in…

This pilot study is investigating how quickly C-reactive protein (CRP), a key marker of inflammation, drops after starting steroid treatment in people newly diagnosed with giant cell arteritis. By measuring CRP levels daily, then weekly and monthly for up to a year, researchers h…

This lab study tests whether a cell-free mixture of molecules and particles released by human amniotic mesenchymal stromal cells can reduce inflammation, prevent scarring, and promote healing in gut tissue from people with inflammatory bowel disease (Crohn's disease or ulcerative…

This study investigates whether nerve ultrasound patterns and biomarkers in blood and spinal fluid can predict how people with chronic inflammatory demyelinating polyneuropathy (CIDP) respond to treatment. Researchers will follow 30 adults with CIDP, including newly diagnosed and…

People with inflammatory bowel disease (Crohn's disease or ulcerative colitis) have a higher risk of developing colorectal cancer. This study follows 800 adults with IBD who need a screening colonoscopy to look for precancerous growths called dysplasia. Researchers aim to underst…

This study explores the personal stories of people diagnosed with cancer of unknown primary (CUP) and their carers. Through interviews and focus groups, researchers aim to understand the emotional and practical challenges of living with this uncertain diagnosis. The findings will…

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study follows 5,000 people with common inflammatory skin conditions—like eczema, psoriasis, and hidradenitis suppurativa—over up to 17 years to see how their disease severity changes. Researchers will collect medical history, treatments, and symptom scores to identify factor…

This observational study looks at whether combining genetic information with standard clinical data can better predict who will develop multiple sclerosis after a first episode of optic neuritis (inflammation of the optic nerve). Researchers will follow 180 people aged 16 and old…

This study checks how consistently six doctors can grade degeneration of the small joints in the spine (facet joints) using CT scans. It includes 12 patients and uses the Pathria scale. The goal is to see if the grading method is reliable, not to test a treatment.

This study looks at two types of liver disease — autoimmune hepatitis and non-alcoholic fatty liver disease — to see if fats in blood cells and tiny particles called extracellular vesicles differ between them. Researchers will collect blood samples from 24 adults and analyze thes…

This study aims to find which eye tests best predict vision in people with surface eye diseases like neurotrophic keratopathy and limbal stem cell deficiency. Researchers will collect data from standard exams and patient questionnaires from 1,000 adults. The goal is to identify k…

This study explores a new way to diagnose Lyme disease by measuring immune cell responses to the bacteria. Researchers use a technique called flow cytometry to analyze T-cells from patients with a late-stage form of Lyme disease. The goal is to see if this method can tell active …

This study looks at whether the standard dose of the antibiotic ceftazidime-avibactam reaches high enough levels in the blood of people with blood cancers or those who have had a stem cell transplant. These patients are at high risk for severe infections from drug-resistant bacte…

This pilot study tests whether using pleuropulmonary ultrasound in the emergency department can help doctors prescribe antibiotics sooner for suspected pneumonia. Fifteen adults with respiratory symptoms will receive an ultrasound in addition to standard care. The main goal is to…

This study investigates whether a particularly dangerous strain of Klebsiella pneumoniae bacteria (hvKP) raises the risk of lung injury in adults with sepsis, compared to a more common strain. Researchers will analyze blood samples for tiny bacterial particles and markers of a sp…

This study tests a cloud-based tool called ACT+ to help people in Uganda get follow-up care after a positive screening for rheumatic heart disease. Researchers will work with local providers to improve the tool and then see if it increases the number of people who complete a conf…

Superficial vein thrombosis (SVT) is a painful but usually harmless blood clot just under the skin. However, about 4% of people develop more serious clots in deep veins or lungs. Current guidelines recommend ultrasound scans to decide if blood thinners are needed, but scans are o…

This study follows 120 adults with ANCA-associated vasculitis, an autoimmune disease, who are receiving rituximab therapy. Researchers will collect blood samples over time to look for immune cell changes that signal a coming relapse. The goal is to find biomarkers that help docto…

This study will measure how well people with gum disease can chew. One hundred adults with periodontitis will chew a special gum for 20 cycles to test their chewing performance. Researchers will also check the severity of their gum disease to see if there is a link. This is an ob…

This study looks at whether treating gum disease (periodontitis) can improve how well people chew and their overall oral quality of life. Researchers will ask 44 adults with gum disease to fill out questionnaires, do a chewing test with colored gum, and provide saliva samples. Th…

This study looks at 200 people with pneumonia to find out how many actually have an infection caused by Chlamydia pneumoniae, a type of bacteria. Researchers will use PCR tests to check for the germ and compare results with standard care. The goal is to see if this infection is o…

This study investigates whether measuring blood flow in the heart's smallest blood vessels (microcirculation) can help predict serious health events within a year after a person is hospitalized for acute myocarditis. Researchers will use a special technique during a standard hear…

This study tests whether people with fibrotic interstitial lung disease can use home monitoring devices—like a spirometer, pulse oximeter, and scale—to help detect serious lung events such as flare-ups or hospitalizations. About 200 participants will use these devices connected t…

This study explores whether changes in heart rate, sleep, and activity measured by a person's own smartwatch can predict flare-ups in inflammatory bowel disease (IBD). Six hundred adults with Crohn's disease or ulcerative colitis who already own a compatible device will participa…

The EXPAND study is a research project that will enroll 440 adults with and without pancreatic conditions to understand why type 2 diabetes varies so much from person to person. Researchers will collect data on metabolism, genetics, and pancreas health to identify distinct diabet…

This study looks at whether a routine blood test can predict which patients with knee osteoarthritis will get good pain relief from platelet-rich plasma (PRP) injections. Researchers will enroll 120 people aged 40-60 with moderate knee arthritis. Each person will receive three PR…

This study will test whether a short health aid—a tool that corrects common misunderstandings about knee osteoarthritis—can help patients feel less worried and make clearer treatment choices. About 159 adults with knee osteoarthritis will be randomly assigned to review the health…

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study follows 100 adults diagnosed with skull base osteomyelitis, a rare and serious bone infection near the ear and skull base. Researchers will track how often the infection returns or leads to death within 12 months. The goal is to gather real-world data to help standardi…

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study aims to create a score that predicts the risk of infection within 30 days after a liver transplant. Researchers will collect blood samples from 279 liver transplant patients before and after surgery to measure immune markers. The goal is to combine these markers with o…

This study looks at how muscle tiredness changes the way female volleyball players move their legs when landing on one foot. Researchers will use smartphone videos to measure hip, knee, and ankle motion in 35 athletes. The goal is to understand injury risks better, not to test a …

This study looks at what changes occur in the kidneys, urine, and blood when people with IgA nephropathy (IgAN) experience loin pain. Researchers will use MRI scans and lab tests to compare findings during a pain episode and when pain-free. The goal is to better understand the ca…

This observational study will collect detailed information from 150 adults undergoing emergency surgery for complicated diverticulitis. Researchers will analyze factors that influence surgeons' decisions to perform either a primary anastomosis (reconnecting the bowel) or a Hartma…

This study investigates whether alexithymia—a condition where people struggle to identify and describe their emotions—affects how well patients with knee osteoarthritis respond to physical therapy. Sixty participants aged 40 to 75 with moderate knee osteoarthritis will receive a …

This study looks at two scoring systems, NEWS-2 and NEWS-Calcium, to see which better predicts the risk of dying in the hospital for people aged 65 and older with acute pancreatitis. Researchers will review medical records of 350 patients to compare the scores. The goal is to hel…

This study looks at 80 people having hip or knee replacement surgery to compare two ways of giving a drug called tranexamic acid, which helps reduce bleeding. Half will get the drug through a standard IV, and the other half will get it injected into the bone. Researchers will mea…

This study looks at how people with skin conditions (like eczema, psoriasis, or skin cancer) manage stress, feel lonely, and bounce back from challenges. Researchers will compare 375 adults with and without skin disease across 15 European countries using questionnaires. The goal …

This study looks at how often muscle weakness and loss (sarcopenia) happens in people aged 15 to 40 with juvenile idiopathic arthritis. Researchers will measure grip strength, do body scans, and use questionnaires to check muscle health. The goal is to find out how common this pr…

This study follows 70 adults aged 20-60 who need root canal treatment on a premolar or molar. Researchers measure how hard they can bite and how force spreads across teeth before treatment, after root canal, after a crown, and up to 4 years later. They also ask about chewing comf…

This study looks at why some patients develop blood clots after pancreatic surgery that also involves removing a piece of a major vein. Researchers will collect information from over 1,000 patients across many hospitals to see how surgical techniques and blood-thinning medication…

This study looks at whether measuring bile acids and pepsin in saliva can help identify people who develop acid reflux or esophageal damage after sleeve gastrectomy (a type of weight-loss surgery). About 60 adults will give saliva samples before surgery and again 1 and 3 years af…

This study will explore if menopause and blood sugar levels are linked to frozen shoulder in women. Researchers will survey women who have had frozen shoulder and closely monitor a smaller group of perimenopausal women with and without the condition. The goal is to understand why…

This study follows 75 adults with Crohn's disease or ulcerative colitis who are starting guselkumab, a drug used for inflammatory bowel disease. Researchers want to see if the drug also helps with joint pain and stiffness linked to spondyloarthritis. Participants will report symp…

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This study will check if people with Lynch syndrome, a genetic condition that raises cancer risk, have more gum disease than the general population. Researchers will look at dental records from 25 adults with Lynch syndrome. The goal is to see if gum disease is a hidden health is…

This study looks at how aging changes tiny parts of our cells called mitochondria, which produce energy. Researchers will take small skin samples and blood from 90 healthy adults aged 18-90 to measure inflammation and cell aging markers. The goal is to better understand why we ag…