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Can a 'No-Cut' gum surgery regrow lost bone?

NCT ID NCT07737678

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Aug 05, 2026 · Updated 3 times

Summary

This trial tests a new surgical technique that avoids cutting the gum tissue between teeth to repair deep bone defects caused by gum disease. The procedure uses a synthetic bone graft and a special gel to help the bone regenerate. The study includes 60 adults aged 35 to 65 with advanced gum disease and specific types of bone defects. Researchers will measure how much bone fills in and whether gum pocket depth and attachment improve.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a synthetic bone graft (beta-tricalcium phosphate and calcium sulfate) and cross-linked hyaluronic acid, delivered via a minimally invasive surgical technique
What this could lead to
If successful, this approach could offer a less invasive way to regenerate bone lost to gum disease, potentially saving teeth and reducing the need for more extensive surgery.
What could go wrong
This is an early-phase trial with only 60 participants, so results may not apply to everyone. Risks include infection, graft failure, or no improvement in bone fill.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age range: 35 to 65 years old. 2. Patients diagnosed with stage III. Periodontitis 3. Presence of isolated intrabony defect with PPD ≥ 6 mm, CAL ≥ 6 mm 4. Intrabony defect depth ≥3 mm. 5. Contained an intrabony defect, 3-wall intrabony defect. 6. No periodontal treatment has been administered in the previous six months. 7. Full-mouth plaque score ≤ 10%. 8. Full-mouth bleeding score ≤ 10%. - Exclusion Criteria: 1. Smokers ≥ 10 cigarettes per day 2. Patient with systemic disease. 3. Pregnant or lactating patients. 4. Patient who has traumatic occlusion. 5. Noncompliant patient. 6. Patient with multi-rooted teeth with class II \& III furcation involvement.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intrabony periodontal defect Periodontal disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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