PERIODONTAL DISEASE

This study tests whether adding a diode laser to standard deep cleaning helps treat gum disease better than cleaning alone. Twenty adults with moderate to severe gum disease will have each side of their mouth randomly assigned to either cleaning plus laser or cleaning only. The m…

This study looks at whether taking coenzyme Q10 (a vitamin-like substance) and probiotics (good bacteria) can help improve gum health in pregnant women who are already getting standard dental cleanings. About 40 pregnant women will be split into two groups: one gets a special too…

This study tests whether a gel containing lovastatin (a cholesterol drug) placed under the gum can improve standard deep-cleaning treatment for periodontitis. About 44 adults, both smokers and non-smokers, will receive the medicated gel on one tooth and a placebo gel on another t…

This study tests whether a hydrogen peroxide mouth rinse (OROXID®) can improve gum health in people with periodontitis, a serious gum infection. About 90 adults with advanced gum disease will use the rinse alongside standard cleaning. The goal is to see if it reduces pocket depth…

This study compares a new interdental brush with other brushes for adults with gum disease. Over 4 weeks, researchers will measure plaque, gum bleeding, and pocket depth. 88 participants will also rate how easy the brush is to use. The goal is to see which brush works best for da…

This study tests if a probiotic spray containing good bacteria can help prevent and treat gum disease in older adults. Researchers will give 90 elderly participants either the probiotic spray or a placebo for 4 weeks. They will measure changes in gum health, bleeding, and bad bre…

This study aims to see if simpler, less invasive methods like taking mouth photos, answering a questionnaire, or testing saliva can accurately detect gum disease (gingivitis and periodontitis). Researchers will compare these methods to the standard full-mouth dental exam in 2,000…

This study tests whether using a toothpaste and mouthwash made with lactoferrin (a natural protein) can prevent gum disease in pregnant women. Forty pregnant women in their second trimester will be split into two groups: one uses both the toothpaste and mouthwash, the other uses …

This study looks at a protein called Mitofusin-1 in saliva to see if it can help measure how severe gum disease is and how well treatment works. Researchers will compare healthy people, those with gum disease, and smokers who have gum disease. Participants give saliva samples and…

This study looks at two types of gum tissue in people with severe gum disease to see how they affect healing after treatment. Researchers will collect tissue samples during gum surgery and compare smokers to non-smokers. The goal is to understand why some tissues heal better and …

This study looks at how problems with the immune system can lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with genetic immune defects and healthy volunteers. The goal is to understand t…

This study looks at how gum health and smoking influence certain inflammatory proteins (inflammasomes) in saliva. Researchers will compare levels of these proteins in people with healthy gums, those with gum disease, and smokers. The goal is to see if these proteins can help diag…

This study is looking at how common a fungus called Candida albicans is in Syrian adults with gum disease (periodontitis). Researchers will check mouth samples from 100 patients to see if the fungus is linked to more severe gum problems. The goal is to better understand the role …

This study looks at the connection between sleep quality and gum disease (periodontitis) in 48 healthy adults. Researchers will measure participants' sleep patterns, fatigue levels, and certain substances in saliva to see if poor sleep is linked to worse gum health. No treatments…