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Fish oil and aspirin: a new hope for Smokers' gum health?

NCT ID NCT07673185

Disease control Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 29, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This study tests whether taking omega-3 fatty acids (fish oil) plus low-dose aspirin can improve gum disease treatment in smokers with advanced periodontitis. Participants receive these supplements or a placebo alongside standard deep-cleaning procedures. The trial measures changes in gum pocket depth, attachment loss, and inflammatory markers over six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Omega-3 fatty acids (EPA and DHA) plus low-dose aspirin
What this could lead to
If effective, this combination could offer a simple, low-cost way to boost gum disease treatment in smokers, reducing inflammation and improving outcomes.
What could go wrong
This is a small, early-stage trial with only 40 participants. Results may not apply to all smokers, and the supplements may not provide significant benefit over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \- Male or female smokers aged 30 to 50 years. * Diagnosed with Stage III periodontitis according to the 2017 World Workshop classification. * Probing pocket depth (PPD) ≥ 5 mm. * Clinical attachment loss (CAL) ≥ 5 mm. * Presence of at least 20 natural teeth. * Willing and able to provide written informed consent. Exclusion Criteria: * \- Systemic diseases affecting periodontal health. * Pregnancy or lactation. * Periodontal treatment within the previous 6 months. * Use of antibiotics or anti-inflammatory drugs within the previous 6 months. * Allergy or hypersensitivity to omega-3 fatty acids or aspirin. * Long-term anticoagulant therapy. * History of gastric ulcer or bleeding disorders. * Participation in another clinical trial within the previous 3 month

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal disease Periodontitis (stage 3) Smoking behaviors

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Dental Medicine for Girls, Al-Azhar University

    RECRUITING

    Cairo, 11651, Egypt

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