PERIODONTAL DISEASE
Clinical trials for PERIODONTAL DISEASE explained in plain language.
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Can probiotics replace antibiotics for gum disease?
Disease control CompletedThis study looked at whether adding probiotics or antibiotics to standard non-surgical gum disease treatment helps improve gum health. Sixty adults with severe periodontitis took part. The goal was to see if probiotics could reduce the need for antibiotics, which can have side ef…
Matched conditions: PERIODONTAL DISEASE
Phase: EARLY_PHASE1 • Sponsor: University of Sao Paulo • Aim: Disease control
Last updated May 26, 2026 07:09 UTC
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Gum bone repair: PRF gel vs. enamel matrix in head-to-head trial
Disease control CompletedThis study tested two treatments for deep bone defects caused by gum disease: platelet-rich fibrin (PRF) gel and enamel matrix derivative (EMD). Twenty-six adults with advanced chronic periodontitis received one of the two treatments during surgery. Researchers measured gum attac…
Matched conditions: PERIODONTAL DISEASE
Phase: PHASE4 • Sponsor: Semmelweis University • Aim: Disease control
Last updated May 26, 2026 07:04 UTC
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Liquorice gel takes on laser in gum disease battle
Disease control CompletedThis study compared a liquorice nanogel to a diode laser as add-on treatments for advanced gum disease (stage III periodontitis). Twenty-seven adults with deep gum pockets were treated. The goal was to see which method better reduced harmful bacteria and improved gum health.
Matched conditions: PERIODONTAL DISEASE
Phase: PHASE3 • Sponsor: Al-Azhar University • Aim: Disease control
Last updated May 26, 2026 07:04 UTC
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App for Moms-to-Be boosts diet and gum health, study finds
Disease control CompletedThis study tested a mobile app called NutriDent4Mom in 264 pregnant women to see if it could improve their diet and gum health. The app provided nutrition and dental care guidance, and researchers compared it to standard care. The goal was to help women get better nutrients and r…
Matched conditions: PERIODONTAL DISEASE
Phase: NA • Sponsor: NORKHAFIZAH SADDKI • Aim: Disease control
Last updated May 22, 2026 14:05 UTC
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New ultrasonic tool for gum disease shows promise in small trial
Disease control CompletedThis study tested a new ultrasonic device with root polishing against standard scaling and root planing for treating gum disease. Forty adults with chronic periodontitis were followed for 6 months. The goal was to see which method better reduced gum pocket depths and improved ove…
Matched conditions: PERIODONTAL DISEASE
Phase: NA • Sponsor: 251 Hellenic Air Force & VA General Hospital • Aim: Disease control
Last updated May 20, 2026 11:56 UTC
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Laser therapy Deep-Cleans Smokers' gums better than standard care
Symptom relief CompletedThis study tested whether adding a diode laser to standard deep-cleaning treatment helps smokers with severe gum disease. Thirty-three smokers were randomly assigned to get either standard cleaning alone or cleaning plus laser. After three months, the laser group had significantl…
Matched conditions: PERIODONTAL DISEASE
Phase: NA • Sponsor: Selcuk University • Aim: Symptom relief
Last updated May 26, 2026 07:16 UTC
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Blood metal levels may link diabetes and gum disease
Knowledge-focused CompletedThis study looked at levels of three metals (chromium, nickel, and magnesium) in the blood of 74 adults with type 2 diabetes and gum disease. Researchers wanted to see if these metals are connected to gum health. The study did not test any treatment, only measured and compared th…
Matched conditions: PERIODONTAL DISEASE
Sponsor: Kahramanmaras Sutcu Imam University • Aim: Knowledge-focused
Last updated May 26, 2026 07:14 UTC
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Tiny camera reveals hidden risks in sinus lifts for dental implants
Knowledge-focused CompletedThis study looked at how often the thin sinus membrane gets torn during a special dental implant procedure. Six people with low bone in their upper jaw had the surgery while a doctor watched with a tiny camera. The goal was to learn more about the safety of this technique, not to…
Matched conditions: PERIODONTAL DISEASE
Phase: NA • Sponsor: Saint-Joseph University • Aim: Knowledge-focused
Last updated May 26, 2026 07:12 UTC
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Smokers' nicotine addiction linked to gum disease ignorance
Knowledge-focused CompletedThis study explored whether how addicted a person is to nicotine affects their awareness of having gum disease. Researchers studied 350 adult smokers with gingivitis or periodontitis, using a nicotine dependence questionnaire and dental exams. The goal was to understand if higher…
Matched conditions: PERIODONTAL DISEASE
Sponsor: Erzincan University • Aim: Knowledge-focused
Last updated May 26, 2026 07:11 UTC
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Gum inflammation and Alzheimer's: blood clues found in 100-patient study
Knowledge-focused CompletedThis study examined whether gum disease and Alzheimer's disease are connected through blood markers. Researchers measured gum health and blood counts in 100 adults over 50 who did not smoke or drink alcohol. The goal was to understand the relationship, not to test a treatment.
Matched conditions: PERIODONTAL DISEASE
Sponsor: Uskudar University • Aim: Knowledge-focused
Last updated May 26, 2026 07:10 UTC
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Gum disease and diabetes: scientists search for hidden clues
Knowledge-focused CompletedThis study examined how gum disease and type 2 diabetes affect each other by measuring immune, bacterial, and other markers in 226 adults aged 30 to 70. Participants were grouped based on their gum health and blood sugar levels. The goal was to better understand the connection be…
Matched conditions: PERIODONTAL DISEASE
Phase: NA • Sponsor: Sanofi Pasteur, a Sanofi Company • Aim: Knowledge-focused
Last updated May 26, 2026 07:09 UTC
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Gum disease and osteoporosis: a hidden link in older women?
Knowledge-focused CompletedThis study looked at 80 women after menopause to see if there is a connection between gum disease and a bone-related protein called sclerostin. Researchers collected blood and gum fluid samples to measure levels of this protein and another marker. The goal was to better understan…
Matched conditions: PERIODONTAL DISEASE
Sponsor: Recep Tayyip Erdogan University • Aim: Knowledge-focused
Last updated May 26, 2026 07:08 UTC
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Radiation's hidden impact: how cancer treatment may trigger gum disease through viruses
Knowledge-focused CompletedThis study looked at 25 patients treated with radiation for head and neck cancers to see how the treatment changes viruses in the mouth, especially the Epstein-Barr virus (EBV). The goal was to understand why many patients develop severe gum disease after radiation. Researchers a…
Matched conditions: PERIODONTAL DISEASE
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated May 26, 2026 07:06 UTC
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Scientists hunt for gum disease clues in spit and gum crevices
Knowledge-focused CompletedThis study looked at certain proteins (GDF-15, Smads, and IL-6) in the saliva and gum fluid of 44 people—22 with gum disease and 22 healthy. The goal was to see if these proteins could help explain how gum disease develops. No treatments were tested; this was purely an observatio…
Matched conditions: PERIODONTAL DISEASE
Sponsor: Melis Yilmaz • Aim: Knowledge-focused
Last updated May 26, 2026 06:52 UTC
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Swallowing wrongly? study links tongue thrust to gum disease
Knowledge-focused CompletedThis study looked at 125 adults with gum disease to see how many also have atypical swallowing—where the tongue pushes against teeth abnormally. Researchers used questionnaires and exams to find links between swallowing patterns and oral problems like loose teeth. The goal is to …
Matched conditions: PERIODONTAL DISEASE
Sponsor: University of Roma La Sapienza • Aim: Knowledge-focused
Last updated May 22, 2026 13:50 UTC
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Gum fluid test could spot hidden gum disease in denture patients
Knowledge-focused CompletedThis study looked at a protein called pentraxin in the gum fluid of people with fixed dentures. The goal was to see if pentraxin levels can help detect early gum disease that isn't visible during a regular checkup. Researchers studied 90 adults who needed fixed dentures and had n…
Matched conditions: PERIODONTAL DISEASE
Sponsor: Jagiellonian University • Aim: Knowledge-focused
Last updated May 20, 2026 11:55 UTC
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Gum disease linked to eye inflammation? new study investigates
Knowledge-focused CompletedThis study compared gum health and inflammatory markers in 25 people with non-infectious uveitis (eye inflammation) and 27 healthy individuals. Researchers measured gum pocket depth, bleeding, and levels of inflammatory proteins in saliva, gum fluid, and blood. The goal was to se…
Matched conditions: PERIODONTAL DISEASE
Sponsor: Selcuk University • Aim: Knowledge-focused
Last updated May 20, 2026 11:54 UTC