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Radiation's hidden impact: mouth viruses under the microscope

NCT ID NCT02180932

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at how radiation therapy for head and neck cancers affects viruses in the mouth, specifically the Epstein-Barr virus (EBV), and how this might relate to gum disease. Researchers collected samples from 25 patients to measure virus levels. The goal was to better understand why many patients develop severe gum problems after radiation, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

25 people

The number who actually took part.

Started

Oct 2014

Finished

Dec 2015

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients ≥ 18 years * Patients treated with curative radiotherapy on tumor site or surgery for cancer of the oral cavity and / or oropharynx * Patients naive treatments for head and neck cancers * Patients affiliated or beneficiary of a social security scheme * Patients who gave informed consent in writing Exclusion Criteria: * Patients treated with neoadjuvant chemotherapy, adjuvant or concomitant * Patients taking immunosuppressants after organ transplantation * Taking anticoagulants incompatible with dental samples (possible bleeding) * Patients edentulous and / or whose dental condition is incompatible with the dental samples

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Conditions

The condition(s) this trial relates to.

head and neck cancer periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal disease

Contacts and locations

Locations

  • Hôpital saint Roch

    Nice, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.