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Gum disease and osteoporosis: hidden link in older women?

NCT ID NCT07294105

Knowledge-focused Sponsor: Recep Tayyip Erdogan University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study examined 80 postmenopausal women to see if there is a connection between gum (periodontal) disease and osteoporosis. Researchers measured two substances in blood and gum fluid called sclerostin and TNF-α, which may help explain how these conditions affect each other. The goal was to gather knowledge, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

80 people

The number who actually took part.

Started

Nov 2022

Finished

May 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Postmenopausal female patients applying to the Periodontics Clinic of Recep Tayyip Erdoğan University Faculty of Dentistry

Ages

43 to 78 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female patients aged 40 years and older in the postmenopausal period, * Individuals diagnosed with osteoporosis or healthy individuals without osteoporosis, as determined by DXA testing of the hip or spine, * Individuals who had been postmenopausal for ≥6 months and had not received hormone replacement therapy, * Patients who did not smoke or consume alcohol, * Female patients who were periodontally healthy or diagnosed with Stage 2-3, Grade A periodontitis Exclusion Criteria: * Patients with chronic renal and hepatic insufficiency; malignant diseases such as diabetes mellitus, leukemia, multiple myeloma, and widespread carcinoma; chronic inflammatory rheumatic diseases such as rheumatoid arthritis and ankylosing spondylitis; and those using drugs that may affect bone metabolism (glucocorticoids, heparin, methotrexate, anticonvulsants), * Those who had received antibiotic therapy in the previous 3 months or any medication for osteoporosis treatment, * Patients who had undergone surgical or non-surgical periodontal treatment within the previous 6 months, * Patients who did not wish to continue participation in the study at the midpoint or at the end of the study.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis postmenopausal osteoporosis sclerosteosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal disease Postmenopausal osteoporosis (PMO)

Contacts and locations

Locations

  • Recep Tayyip Erdoğan University

    Rize, Rize Province, 53020, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.