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Can probiotics replace antibiotics for gum disease?

NCT ID NCT07592416

Disease control Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding probiotics or antibiotics to standard non-surgical gum disease treatment helps improve gum health. Sixty adults with severe periodontitis took part. The goal was to see if probiotics could be a safer alternative to antibiotics, which can cause side effects like antibiotic resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

60 people

The number who actually took part.

Started

Aug 2023

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults with a diagnosis of generalized periodontitis, defined as involvement of ≥30% of teeth, classified as: Stage III or Stage IV, and Grade B or Grade C, according to the 2018 classification. * Presence of at least one tooth with ≥1 interproximal site exhibiting: Probing depth (PD) ≥6 mm, and Clinical attachment loss (CAL) ≥5 mm. * Presence of at least 15 teeth, excluding third molars and teeth indicated for extraction. * Presence of at least 6 non contiguous teeth, each with ≥1 interproximal site presenting PD and CAL ≥5 mm. Exclusion Criteria: * Current smokers or former smokers who quit less than 5 years prior to enrollment. * Pregnant or breastfeeding women. * History of periodontal treatment within the previous 6 months. * Continuous use of oral antiseptics within the last 6 months. * Use of systemic antibiotics, corticosteroids, non steroidal anti inflammatory drugs, immunosuppressants, estrogen, estrogen receptor modulators, or medications affecting bone metabolism (e.g., alendronate, calcitonin) within the last 6 months. * Presence of systemic conditions that may alter the host response, including: Diabetes mellitus, HIV infection, Down syndrome. * Medical conditions requiring antibiotic prophylaxis for dental procedures (e.g., mitral valve prolapse). * Known allergy or hypersensitivity to amoxicillin, metronidazole, penicillins, or related compounds. * Use of probiotics within the last 6 months.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy adult participants Periodontal disease

Contacts and locations

Locations

  • Universidade de São Paulo

    Ribeirão Preto, São Paulo, 14040-904, Brazil

More trials for these conditions

Other studies related to the condition(s) this trial covers.