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Gum fluid proteins eyed as link between smoking and periodontitis

NCT ID NCT07826728

Knowledge-focused Sponsor: Abant Izzet Baysal University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Researchers are studying whether cigarette smoking is linked to levels of two proteins, MFN1 and NLRP3, in the fluid between the teeth and gums. The study includes 88 adults aged 25 to 65, split into four groups: nonsmokers and smokers with healthy gums, and nonsmokers and smokers with periodontitis. Participants give health and smoking information, have a gum exam, and provide small fluid samples from around the gums. The researchers compare protein levels across the groups and look at how they relate to gum measurements and smoking history. No experimental treatment is given, and those with periodontitis receive routine care after samples are collected.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the study finds a clear link between smoking, these proteins, and gum disease, it could help researchers design better ways to spot or treat periodontitis in smokers.
What could go wrong
This is a small observational study of 88 people, so it can only show associations, not cause and effect. The results may not apply to other groups or may be explained by factors the study does not measure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 88 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 18-65 years attending the Department of Periodontology, Faculty of Dentistry, Bolu Abant Izzet Baysal University, Bolu, Türkiye, will be assessed for eligibility. Participants will have at least 20 natural teeth and either periodontal health on an intact periodontium or Stage III or Stage IV periodontitis. Four groups will be formed according to periodontal status and cigarette smoking history: periodontally healthy nonsmokers, periodontally healthy smokers, nonsmokers with periodontitis, and smokers with periodontitis.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18-65 years. At least 20 natural teeth. For the periodontal health groups: periodontal health on an intact periodontium, with probing depths ≤3 mm, full-mouth bleeding on probing \<10%, and no interdental clinical attachment loss or radiographic bone loss attributable to periodontitis. For the periodontitis groups: Stage III or Stage IV periodontitis according to the 2017 periodontal disease classification. For the smoking groups: current cigarette smoking of at least 10 cigarettes per day for at least 5 years. For the nonsmoking groups: fewer than 100 cigarettes smoked during the lifetime and no current use of tobacco or nicotine products. Provision of written informed consent. Exclusion Criteria: * ormer cigarette smoking. Use of electronic cigarettes, heated tobacco products, nicotine pouches, or nicotine replacement products. Uncontrolled diabetes, immunodeficiency, autoimmune or chronic inflammatory disease, or a serious systemic disease that may affect periodontal or mitochondrial responses. Pregnancy or breastfeeding. Use of antibiotics, systemic corticosteroids, immunosuppressive medications, or regular anti-inflammatory medications within the previous 3 months. Periodontal treatment within the previous 6 months. Acute oral infection, periodontal abscess, or local pathology affecting the sampling sites. Gingival crevicular fluid samples contaminated with blood or saliva, or insufficient for ELISA analysis.

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Conditions

The condition(s) this trial relates to.

periodontitis Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis Smoking

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Faculty of Dentistry, Bolu Abant İzzet Baysal University, Department of Periodontics

    RECRUITING

    Bolu, Central, 14100, Turkey (Türkiye)

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