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Can ancient ayurvedic remedies outperform modern medicine for knee pain?

NCT ID NCT07768709

Disease control Sponsor: All India Institute of Medical Sciences, Jodhpur Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 17, 2026 · Last updated Aug 28, 2026 · Updated 3 times

Summary

This trial tests whether combining traditional Ayurvedic treatments with standard medical care can better ease knee osteoarthritis symptoms than either approach alone. It enrolls 300 adults aged 30-65 with mild to moderate knee osteoarthritis, randomly assigning them to receive standard care, Ayurvedic care, or an integrated mix of both for 24 weeks. Researchers will measure changes in pain, stiffness, physical function, knee temperature, and walking patterns to see which approach offers the most relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ayurvedic herbal formulations (Trayodashang Guggulu, Ashwagandha Churna), Janubasti procedure, and standard medical care (paracetamol, diclofenac, TENS, heat/cold therapy)
What this could lead to
If successful, this could show that combining Ayurvedic and standard treatments offers better pain relief and mobility for early knee osteoarthritis than either approach alone.
What could go wrong
This is an early-stage trial with no placebo, so results may be influenced by expectations. The herbal and procedural interventions may not outperform standard care, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 30 and 65 years, including males and females both * Diagnosis of primary osteoarthritis (OA) affecting at least one knee joint. * Kellgren-Lawrence (KL) grading of 1 or 2, indicating mild to moderate OA severity. * Baseline Numeric Rating Scale (NRS) score of ≥ 5 out of 10, indicating moderate to severe pain intensity. Exclusion Criteria: * Secondary arthritis due to systemic inflammatory arthritis. * History of post-traumatic knee osteoarthritis. * Previous total knee replacement (TKR) surgery. * Recent corticosteroid use for knee-related conditions. * Prior intra-articular viscosupplementation treatment. * Allergy to allopathic and Ayurvedic medications used in the study. * Concomitant skin disease at the application site of any study intervention. * Uncontrolled diabetes mellitus * Chronic Renal failure * Pregnant and lactating females

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis (knee oa) Primary knee osteoarthritis (kellgren-lawrence grade 1-2)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • All India Institute of Medical Sciences, Jodhpur

    Jodhpur, Rajasthan, 342005, India

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