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Herbal drops aim to melt away sore throat pain

NCT ID NCT07761013

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial tests whether Yanlishuang buccal dropping pills, a traditional Miao medicine, can relieve the sore throat and pain of acute pharyngitis. About 400 adults with a sore throat that started within the last 48 hours will be randomly assigned to take either the herbal drops or a placebo for up to 5 days. The main goal is to see how quickly the sore throat completely resolves, with secondary measures looking at immediate pain relief and other symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Yanlishuang Buccal Dropping Pills (a Miao medicine containing natural borneol, Blumea balsamifera oil, peppermint oil, menthol, and monoammonium glycyrrhizinate)
What this could lead to
If effective, this could offer a new, non-prescription-like option for quickly soothing sore throats and reducing pain from acute pharyngitis.
What could go wrong
This is an early-stage trial, and the placebo effect for pain relief can be strong. The results may not show a clear benefit, and the herbal ingredients could cause side effects in some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 65 years, inclusive, of any sex. * Baseline throat-pain visual analog scale score of at least 4. * Meets the protocol-defined Western medicine diagnostic criteria for acute pharyngitis. * Acute onset with disease duration of 48 hours or less. * Provides written informed consent and is able to follow the study protocol. Exclusion Criteria: * Prior use of Yanlishuang Buccal Dropping Pills before enrollment, or use before enrollment of any other Chinese or Western medicine for the target disease that, in the investigator's judgment, may affect efficacy evaluation. * Prodromal or accompanying throat symptoms of an acute infectious disease, such as measles, scarlet fever, or infectious mononucleosis; suppurative tonsillitis; peritonsillar abscess; retropharyngeal abscess; acute epiglottitis; or throat symptoms caused by another disease. * Modified Centor score of at least 2, with white blood cell count, absolute neutrophil count, and C-reactive protein all above the upper limit of normal, when the investigator considers bacterial infection or antibiotic treatment necessary. * Concurrent bacterial otitis media, sinusitis, laryngitis, bronchitis, pneumonia, acute nephritis, rheumatic fever, sepsis, or a similar complication. * Severe primary disease of the central nervous, hematopoietic, endocrine, cardiovascular/cerebrovascular, digestive, or other system, or a psychiatric disorder, that the investigator considers may affect participant safety or materially affect clinical evaluation. * Abnormal hepatic or renal function: alanine aminotransferase or aspartate aminotransferase greater than 1.5 times the upper limit of normal and/or serum creatinine above the upper limit of normal. * Suspected or confirmed history of alcohol or drug abuse. * Pregnancy, breastfeeding, preparation for pregnancy, or a recent childbearing plan. * Known allergy to any component of the study medication. * Participation in another clinical trial and use of an investigational product within the previous 1 month. * Constitutional spleen-stomach deficiency-cold or a condition considered unsuitable for study medication, including but not limited to acute or chronic gastritis, erosive gastritis, or gastroesophageal reflux disease. * Any other condition that the investigator considers makes the individual unsuitable for participation.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    10 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Affiliated Hospital of Chengdu University of Traditional Chinese Medicine / Sichuan Provincial Hospital of Traditional Chinese Medicine

    Chengdu, Sichuan, China

  • Affiliated Hospital of Guizhou Medical University

    Guiyang, Guizhou, China

  • First Affiliated Hospital of Guangzhou University of Chinese Medicine

    Guangzhou, Guangdong, China

  • First Affiliated Hospital of Heilongjiang University of Chinese Medicine

    Harbin, Heilongjiang, China

  • First Affiliated Hospital of Shandong University of Traditional Chinese Medicine / Shandong Provincial Hospital of Traditional Chinese Medicine

    Jinan, Shandong, China

  • First Affiliated Hospital of Yunnan University of Chinese Medicine / Yunnan Provincial Hospital of Traditional Chinese Medicine

    Kunming, Yunnan, China

  • First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

    Tianjin, Tianjin Municipality, China

  • Jiangsu Province Hospital of Chinese Medicine

    Nanjing, Jiangsu, China

  • Jiangxi Provincial Hospital of Traditional Chinese Medicine

    Nanchang, Jiangxi, China

  • Shanghai Municipal Hospital of Traditional Chinese Medicine

    Shanghai, Shanghai Municipality, China

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