Herbal drops aim to melt away sore throat pain
NCT ID NCT07761013
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial tests whether Yanlishuang buccal dropping pills, a traditional Miao medicine, can relieve the sore throat and pain of acute pharyngitis. About 400 adults with a sore throat that started within the last 48 hours will be randomly assigned to take either the herbal drops or a placebo for up to 5 days. The main goal is to see how quickly the sore throat completely resolves, with secondary measures looking at immediate pain relief and other symptoms.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Yanlishuang Buccal Dropping Pills (a Miao medicine containing natural borneol, Blumea balsamifera oil, peppermint oil, menthol, and monoammonium glycyrrhizinate)
- What this could lead to
- If effective, this could offer a new, non-prescription-like option for quickly soothing sore throats and reducing pain from acute pharyngitis.
- What could go wrong
- This is an early-stage trial, and the placebo effect for pain relief can be strong. The results may not show a clear benefit, and the herbal ingredients could cause side effects in some people.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 400 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18 to 65 years, inclusive, of any sex. * Baseline throat-pain visual analog scale score of at least 4. * Meets the protocol-defined Western medicine diagnostic criteria for acute pharyngitis. * Acute onset with disease duration of 48 hours or less. * Provides written informed consent and is able to follow the study protocol. Exclusion Criteria: * Prior use of Yanlishuang Buccal Dropping Pills before enrollment, or use before enrollment of any other Chinese or Western medicine for the target disease that, in the investigator's judgment, may affect efficacy evaluation. * Prodromal or accompanying throat symptoms of an acute infectious disease, such as measles, scarlet fever, or infectious mononucleosis; suppurative tonsillitis; peritonsillar abscess; retropharyngeal abscess; acute epiglottitis; or throat symptoms caused by another disease. * Modified Centor score of at least 2, with white blood cell count, absolute neutrophil count, and C-reactive protein all above the upper limit of normal, when the investigator considers bacterial infection or antibiotic treatment necessary. * Concurrent bacterial otitis media, sinusitis, laryngitis, bronchitis, pneumonia, acute nephritis, rheumatic fever, sepsis, or a similar complication. * Severe primary disease of the central nervous, hematopoietic, endocrine, cardiovascular/cerebrovascular, digestive, or other system, or a psychiatric disorder, that the investigator considers may affect participant safety or materially affect clinical evaluation. * Abnormal hepatic or renal function: alanine aminotransferase or aspartate aminotransferase greater than 1.5 times the upper limit of normal and/or serum creatinine above the upper limit of normal. * Suspected or confirmed history of alcohol or drug abuse. * Pregnancy, breastfeeding, preparation for pregnancy, or a recent childbearing plan. * Known allergy to any component of the study medication. * Participation in another clinical trial and use of an investigational product within the previous 1 month. * Constitutional spleen-stomach deficiency-cold or a condition considered unsuitable for study medication, including but not limited to acute or chronic gastritis, erosive gastritis, or gastroesophageal reflux disease. * Any other condition that the investigator considers makes the individual unsuitable for participation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
10 sites. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Affiliated Hospital of Chengdu University of Traditional Chinese Medicine / Sichuan Provincial Hospital of Traditional Chinese Medicine
Chengdu, Sichuan, China
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Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, China
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First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, China
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First Affiliated Hospital of Heilongjiang University of Chinese Medicine
Harbin, Heilongjiang, China
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First Affiliated Hospital of Shandong University of Traditional Chinese Medicine / Shandong Provincial Hospital of Traditional Chinese Medicine
Jinan, Shandong, China
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First Affiliated Hospital of Yunnan University of Chinese Medicine / Yunnan Provincial Hospital of Traditional Chinese Medicine
Kunming, Yunnan, China
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First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Tianjin, Tianjin Municipality, China
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Jiangsu Province Hospital of Chinese Medicine
Nanjing, Jiangsu, China
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Jiangxi Provincial Hospital of Traditional Chinese Medicine
Nanchang, Jiangxi, China
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Shanghai Municipal Hospital of Traditional Chinese Medicine
Shanghai, Shanghai Municipality, China
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