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Can ancient frankincense Out-Clean the Dentist's standard root canal rinse?

NCT ID NCT07823868

Disease control Sponsor: Oman Dental College Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers test whether a rinse made from frankincense (Boswellia sacra) removes bacteria from infected root canals as well as the standard sodium hypochlorite rinse. Thirty adults aged 18 to 50 with a dead or infected tooth take part. Each person is randomly assigned to one of the two rinses. Before and after cleaning, a painless sample from inside the tooth is tested with PCR to measure bacteria levels, and the two groups are compared.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A frankincense-based root canal cleaning liquid made from Boswellia sacra extract
What this could lead to
If it works, a natural, possibly gentler rinse could become an option for cleaning infected root canals.
What could go wrong
This is a small, early-stage study of 30 people, so it may not show whether frankincense matches the standard rinse. The extract could fail to kill enough bacteria or cause unexpected reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-50 years * Diagnosis of pulpal necrosis (single- or multi-rooted tooth), with or without apical periodontitis * Tooth suitable for standard endodontic access and microbiological sampling Exclusion Criteria: * Periodontal pockets \>4 mm * Calcified canals * Acute apical abscess * Internal resorption * Open apex * Retreatment cases * Antibiotic/ herbal therapy within the prior 3 months * Pregnancy * Systemic comorbidities

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Conditions

The condition(s) this trial relates to.

dental abscess dental pulp necrosis periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis Pulp necrosis Root canal infection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Oman dental college

    Muscat, 111, Oman

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