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Breathing workouts could give knee pain sufferers a leg up

NCT ID NCT07738627

Disease control Sponsor: Riphah International University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Aug 28, 2026 · Updated 3 times

Summary

This trial tests whether adding inspiratory muscle training (IMT) — breathing exercises using a resistance device — to usual care can improve cardiopulmonary endurance and functional mobility in people with knee osteoarthritis. Adults aged 40-65 with bilateral knee osteoarthritis will be assigned to either real IMT or a sham version, alongside standard treatment. Over six weeks, researchers will measure walking endurance, mobility, pain, and quality of life to see if stronger breathing muscles translate into better daily function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Inspiratory muscle training using a POWERbreathe device
What this could lead to
If effective, this could offer a simple, drug-free addition to standard care that improves walking endurance and daily mobility for people with knee osteoarthritis.
What could go wrong
This is a small, early-stage trial, and the benefits may be modest or not outweigh the effort. The sham device is designed to mimic training, so results may not show a clear advantage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 65 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 40-65 years * Male and Female participants * Bilateral Knee Osteoarthritis * Diagnosed according to American College of Rheumatology criteria * Kellgren and Lawrence Grade II-III * Able to walk independently * Willing to provide informed consent Exclusion Criteria: * Participation in structured physical activity programs * Intra-articular corticosteroid injection within last 3 months * Hyaluronic acid injection within last 6 months * Lower limb trauma or surgery history * Planned surgery during study period * Severe cardiovascular disease * Severe pulmonary disease * Neurological disorders * Psychological disorders

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • IIMCT Railway general hospital

    Rawalpindi, Punjab Province, 46060, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.