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Ice vs spray: which stops chemo mouth pain?

NCT ID NCT07727031

Symptom relief Sponsor: Hanady Jabbar Mahmood Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial compares two simple treatments—sucking on ice chips or using a lidocaine spray—to see which better prevents or reduces painful mouth sores caused by chemotherapy. About 60 adults with cancer who are about to receive chemotherapy will be randomly assigned to one of the two approaches. Researchers will track sore severity and pain levels to find out which method offers more relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
oral cryotherapy (ice chips) and topical lidocaine spray
What this could lead to
If one method works better, it could offer a simple, low-cost way to prevent or ease painful mouth sores during chemotherapy.
What could go wrong
This is a small, early-stage trial with only 60 participants, so results may not apply to everyone. Both methods may provide only partial relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Histologically or cytologically confirmed diagnosis of cancer. * Scheduled to receive chemotherapy associated with a moderate or high risk of oral mucositis. * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2. * Able to understand the study procedures and provide written informed consent. * Willing to comply with all study procedures and follow-up assessments. Exclusion Criteria: * Receiving concurrent head and neck radiotherapy. * Presence of severe pre-existing oral disease or active oral infection that may interfere with outcome assessment. * Known hypersensitivity or contraindication to lidocaine or its components. * Medical contraindication or intolerance to oral cryotherapy (e.g., cold hypersensitivity, cryoglobulinemia, or cold agglutinin disease). * Cognitive impairment or psychiatric illness preventing informed consent or study participation. * Participation in another interventional clinical trial for the prevention or treatment of oral mucositis during the study period. * Pregnant or breastfeeding women (if specified as ineligible in the study protocol).

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Conditions

The condition(s) this trial relates to.

cancer neoplasm stomatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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