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New fizzy tablet could keep dentures Germ-Free

NCT ID NCT07608211

Disease control Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a new experimental effervescent tablet can clean removable partial dentures better than a commercial cleanser or water. Fifteen adults with denture stomatitis will wear dentures with small material discs to collect plaque, then soak them daily in one of three solutions for 14-day cycles. Researchers will measure how many bacteria and fungi survive, and ask participants about taste, odor, and cleanliness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants aged 18 years or older. * Users of maxillary and/or mandibular removable partial dentures (RPD) made of acrylic resin. * Good systemic and oral health status, with enough healthy remaining teeth to support the RPD. * Agreement to follow the requested oral hygiene and denture cleaning protocols. * Ability to understand and sign the Informed Consent Form. Exclusion Criteria: * Use of systemic antibiotics, antifungals, or anti-inflammatory drugs within the last 3 months. * History of allergic reactions to N-acetylcysteine (NAC), Melaleuca alternifolia (tea tree) oil, or components of the commercial positive control (NitrAdine). * Severe periodontal disease or extensive untreated caries in the remaining teeth. * Severe systemic diseases, immunodeficiency, or conditions that compromise manual dexterity to perform denture brushing. * Pregnant or lactating women.

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Conditions

The condition(s) this trial relates to.

denture stomatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Denture stomatitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • School of Dentistry of Ribeirão Preto

    Ribeirão Preto, São Paulo, 14051260, Brazil

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