New scan aims to tell two types of hand arthritis apart
NCT ID NCT07624994
First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time
Summary
This study tests a special imaging agent (99mTc-NTP 15-5) to see if it can spot arthritis-damaged joints in the hands and tell the difference between osteoarthritis and rheumatoid arthritis. About 80 adults with one of these conditions will get a scan. The goal is to improve diagnosis, not to treat the disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Jul 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Karnofsky index \> 70% * Obtaining written, signed and dated informed consent * Affiliation to a health insurance plan * For women of childbearing age (fertile, after menarche and until postmenopausal unless sterile after surgery) including on GnRH agonist for ovarian suppression: serum pregnancy test negative at baseline (within 7 days before injection of 99mTc-NTP 15-5). Menopause is defined as amenorrhea for at least 12 consecutive months with no other cause and FSH and oestradiol levels consistent with those of the post-menopausal period. * Ability and willingness to respect study visits, exams as well as protocol. RA Group: * certain diagnosis of rheumatoid arthritis less than 5 years old, according to the ACR/EULAR criteria, * symptomatic (finger pain \> 4 /10 on a numerical scale), * active synovitis (clinical and ultrasound), Group DOA: * certain diagnosis of symptomatic DOA less than 5 years old (finger pain \> 4 /10 on a numerical scale), * stopping NSAIDs for at least 8 days before the injection, Exclusion Criteria: * Ongoing use of non-steroidal anti-inflammatory drugs, * Treatment by local joint corticoid infiltration at the hand level in the month preceding the administration of 99mTc-NTP 15-5, * History of osteoarticular hand surgery. * History of hand soft tissue surgery in the past 6 months * Patients or patients 18 years old, * Pregnant or breastfeeding patient, * IMC\>30, * History of known allergy to excipients contained in the 99mTc-NTP 15-5 solution, * Persons deprived of their liberty, under guardianship/curatorship, or safeguarding of justice, * Inability to submit to the medical follow-up of the trial for geographical, family, social or psychological reasons. These conditions must be discussed with the patient before registration in the study. RA Group: * Use of biotherapies (anti-TNF alpha, rituximab, abatacept, anti-IL6 and anti-JAK) as background treatment. * Patients with a history of hand DOA
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Centre Jean Perrin
Clermont-Ferrand, PUY DE DOME, 63011, France
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Chu Clermont Ferrand
Clermont-Ferrand, France
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