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Could a cold rinse during root canals ease Post-Procedure pain?

NCT ID NCT07676409

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests whether using very cold water (around 2-3°C) to rinse the inside of a tooth during a root canal can lower pain afterward. The trial includes adults aged 20-40 with painful, infected lower molars. Participants are randomly assigned to receive either cold rinses throughout the procedure, a cold rinse only at the end, or standard room-temperature rinses. Pain levels are tracked for 72 hours after treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cold saline and cold sodium hypochlorite solution
What this could lead to
If effective, this simple cold-water rinse during root canals could become a standard way to ease pain after the procedure.
What could go wrong
This is a small, early-stage trial with only 45 participants, so results may not apply to everyone. The cold rinse might not reduce pain more than standard methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age between 20-40 years old. 2. Systemically healthy patients (ASA I or II). 3. Mature Mandibular molar teeth with : * Preoperative sharp pain and symptomatic apical periodontitis marked on NRS scale by reading not less than 6. * Absence or slight widening in the periodontal ligament (PDL). * Vital response of pulp tissue to cold pulp tester and (ethyl chloride spray). * Positive response to percussion test. 4. Restorable teeth. 5. Ability to complete the endodontic treatment in a single visit. 6. Positive patient acceptance for participation in the trial. ----------------------------------------------------------------- Exclusion Criteria: 1. Medically compromised patients (ASA III or IV) 2. Patients who used NSAIDs in the 24 hours before treatment. 3. Patients with two or more adjacent teeth requiring endodontic treatment. 4. Pregnant women. 5. Patients reporting bruxism or clenching. 6. Teeth associated with : * Acute periapical abscess and/or swelling. * Greater than grade I mobility or pocket depth greater than 5mm. * Non-restorable teeth. * Immature Apex. 7. Radiographic evidence of external or internal root resorption, vertical root fracture, perforation, calcification.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cryotherapy

How to take part

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  1. The official record

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