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Chilling a tooth from the inside: could cold saline ease Post-Root-Canal pain?

NCT ID NCT07733700

Symptom relief Sponsor: Alanya Alaaddin Keykubat University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether flushing the inside of a tooth with cold saline (about 2.5°C) after root canal retreatment can lower pain and inflammation. One hundred adults needing retreatment on a lower premolar will be randomly assigned to receive either cold or room-temperature saline. Researchers will measure pain levels and inflammatory markers in saliva and gum fluid over a week to see if the cold rinse makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intracanal cryotherapy (cold saline irrigation at 2.5°C)
What this could lead to
If it works, this could offer a simple, low-cost way to reduce pain and inflammation after root canal retreatment.
What could go wrong
This is a small, early-stage trial. The cooling effect may not significantly reduce pain or biomarkers, and results may not apply to other teeth or patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-65 years, systemically healthy individuals (ASA I-II) * Single-rooted mandibular premolar teeth with a previous root canal treatment, requiring non-surgical retreatment due to asymptomatic apical periodontitis * Presence of periapical radiolucency (Periapical Index \[PAI\] ≥ 3) * No antibiotic use within the past 1 month * Willing to participate and has signed the informed consent form Exclusion Criteria: * Pregnancy or lactation * Uncontrolled diabetes mellitus (HbA1c \> 7%), diagnosed autoimmune disease, or receiving immunosuppressive therapy * Systemic corticosteroid use within the past 3 months * Body mass index (BMI) greater than 35 kg/m² * Presence of acute infection (e.g., acute apical abscess or cellulitis) * Conditions precluding retreatment, including advanced periodontal breakdown (clinical attachment loss \> 5 mm), root resorption, perforation, or advanced canal calcification * Absence of an opposing (antagonist) tooth resulting in lack of functional occlusal contact * Diagnosed chronic pain syndrome or currently receiving active psychiatric treatment * Smoking more than 10 cigarettes per day * Use of analgesics or NSAIDs within the past 24 hours * Antibiotic use within the past 1 month

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis hereditary sensory and autonomic neuropathy Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asymptomatic apical periodontitis Cryotherapy Endodontic retreatment

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Alanya Alaaddin Keykubat University, Faculty of Dentistry

    Antalya, ALANYA, 07400, Turkey (Türkiye)

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