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New MRI techniques could sharpen diagnosis of optic nerve inflammation

NCT ID NCT07748819

Diagnosis Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study tests whether two advanced MRI techniques, called Double Inversion Recovery (DIR) and Diffusion Tensor Imaging (DTI), can improve the assessment of optic neuritis—inflammation of the optic nerve that can affect vision. Researchers will compare MRI measurements of the affected nerve between people with optic neuritis and healthy volunteers, and see how these measurements relate to visual outcomes. The goal is to determine if these imaging methods can more accurately detect and characterize optic nerve damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MRI scans using Double Inversion Recovery (DIR) and Diffusion Tensor Imaging (DTI) sequences
What this could lead to
If successful, this could lead to more accurate MRI-based assessment of optic neuritis, helping to predict visual outcomes and guide treatment decisions.
What could go wrong
This is a relatively small, early-stage study. The imaging techniques may not prove to be more useful than standard MRI, and results may not apply to all patients with optic neuritis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults with clinically suspected optic neuritis referred for MRI evaluation, together with healthy control participants.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age above 18 years. * Clinically suspected optic neuritis. * Evidence of multiple sclerosis or other demyelinating diseases. Exclusion Criteria: * Traumatic optic neuritis. * Systemic diseases affecting the optic nerve. * Contraindications to MRI.

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Conditions

The condition(s) this trial relates to.

optic nerve disorder optic neuritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Optic nerve disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.