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New weekly shot aims to ease arthritic knee pain and shed pounds

NCT ID NCT07353931

Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Sep 09, 2026 · Updated 9 times

Summary

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for about 75 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
eloralintide (a weekly injection)
What this could lead to
If it works, this could provide a new treatment that eases knee pain and helps with weight loss in people with osteoarthritis and obesity.
What could go wrong
This is a large Phase 3 trial, but the drug is still experimental. It may not work better than placebo, and side effects are possible. Results may not apply to everyone with osteoarthritis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 900 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening * Have a stable body weight (less than 5% body weight change) for 90 days prior to screening * Have tried at least once to lose weight through diet but were unsuccessful * Have osteoarthritis of the knee and at least one of the following conditions: * Be over 50 years old * Have morning knee stiffness that lasts about 30 minutes * Have a crackling or grinding sound or feeling in the knee Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes, type 2 diabetes, or any other type of diabetes * Have an active knee infection * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure * Have taken medications or alternative remedies intended for weight loss within 90 days of screening

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder osteoarthritis osteoarthritis, knee Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis Overweight or obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    152 sites in 14 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 2nd Affiliated Hospital Chongqing Medical Universi

    RECRUITING

    Chongqing, 400000, China

  • AMR Clinical

    RECRUITING

    Mobile, Alabama, 36608, United States

  • AMR Clinical

    RECRUITING

    Newton, Kansas, 67114, United States

  • AMR Clinical

    RECRUITING

    South Jordan, Utah, 84095, United States

  • AmBeNet GmbH

    RECRUITING

    Leipzig, 04107, Germany

  • Antwerp University Hospital

    RECRUITING

    Edegem, 2650, Belgium

  • Apex Trials

    RECRUITING

    Guelph, N1G 0B4, Canada

  • Ark Clinical Research - Fountain Valley

    RECRUITING

    Fountain Valley, California, 92708, United States

  • Asan Medical Center

    RECRUITING

    Seoul, 05505, South Korea

  • Atlantic Medical

    RECRUITING

    Penzance, TR18 3DX, United Kingdom

  • Beijing Ji Shui Tan Hospital

    RECRUITING

    Beijing, 100035, China

  • Boramae Medical Center

    RECRUITING

    Dongjak-gu, 07061, South Korea

  • CARDIAMET Investigaciones Médicas

    NOT_YET_RECRUITING

    Buenos Aires, C1014ACP, Argentina

  • CDG Studienambulanz Hartard

    RECRUITING

    München, 80809, Germany

  • CEPIC - Centro Paulista de Investigação Clínica

    SUSPENDED

    São Paulo, 04266-010, Brazil

  • CPHosp Medicina, Ensino e Pesquisa (CPQuali)

    SUSPENDED

    São Paulo, 01228-000, Brazil

  • Care Access - 801 South Power Road, Mesa

    RECRUITING

    Mesa, Arizona, 85206, United States

  • Care Access - Houston

    RECRUITING

    Houston, Texas, 77054, United States

  • Care Access - Quincy

    RECRUITING

    Quincy, Massachusetts, 02169, United States

  • Care Access - St. Petersburg

    RECRUITING

    St. Petersburg, Florida, 33710, United States

  • Central States Research

    RECRUITING

    Tulsa, Oklahoma, 74136, United States

  • Centro Médico Arsema

    NOT_YET_RECRUITING

    Buenos Aires, C1427CCL, Argentina

  • Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan

    NOT_YET_RECRUITING

    San Juan, 5400, Argentina

  • Centro Privado de Medicina Familiar / Mindout Research

    NOT_YET_RECRUITING

    Buenos Aires, 1417, Argentina

  • Centro de Investigaciones Clínicas Baigorria

    NOT_YET_RECRUITING

    Granadero Baigorria, 2152, Argentina

  • Centro de Investigaciones Médicas Tucuman

    NOT_YET_RECRUITING

    SAN M. de Tucuman, T4000AXL, Argentina

  • Centro de Investigaciones Reumatológicas

    NOT_YET_RECRUITING

    San Miguel de Tucumán, 4000, Argentina

  • Centro de Pesquisa Sao Lucas

    SUSPENDED

    Campinas, 13060-803, Brazil

  • Chang Gung Memorial Hospital at Kaohsiung

    NOT_YET_RECRUITING

    Kaohsiung Niao Sung Dist, 83301, Taiwan

  • Changhua Christian Hospital

    RECRUITING

    Changhua County, 50006, Taiwan

  • Charlottesville Medical Research

    RECRUITING

    Charlottesville, Virginia, 22911, United States

  • China Medical University Hospital

    RECRUITING

    Taichung, 404332, Taiwan

  • Conquest Research

    RECRUITING

    Winter Park, Florida, 32789, United States

  • Consano Clinical Research, LLC

    RECRUITING

    Shavano Park, Texas, 78231, United States

  • Dedicated Research Site FutureMeds

    RECRUITING

    Offenbach, 63065, Germany

  • Diablo Clinical Research, Inc.

    RECRUITING

    Walnut Creek, California, 94598, United States

  • Diex Recherche Inc. Division Quebec

    RECRUITING

    Québec, G1V 4T3, Canada

  • Diex Recherche Inc. Division Victoriaville

    RECRUITING

    Victoriaville, G6P 3Z8, Canada

  • Dorado Medical Complex

    RECRUITING

    Dorado, 00646, Puerto Rico

  • Dr. Anil K. Gupta Medicine Professional Corporation

    RECRUITING

    Toronto, M9V 4B4, Canada

  • Elite Clinical Studies, LLC

    RECRUITING

    Phoenix, Arizona, 85018, United States

  • Elite Pain and Spine Institute - South Crimson Road

    RECRUITING

    Mesa, Arizona, 85209, United States

  • Ellipsis Research Group - Brooklyn - 7th Street

    RECRUITING

    Brooklyn, New York, 11215, United States

  • Encompass Clinical Research

    RECRUITING

    Spring Valley, California, 91978, United States

  • Endeavor Clinical Trials

    RECRUITING

    San Antonio, Texas, 78240, United States

  • Epic Medical Research - DeSoto

    RECRUITING

    DeSoto, Texas, 75115, United States

  • Fujigaki Clinic

    RECRUITING

    Ōita, 870-0942, Japan

  • FutureMeds - London

    RECRUITING

    London, NW10 2PB, United Kingdom

  • FutureMeds Glasgow - CPS Research

    RECRUITING

    Glasgow, G20 7BE, United Kingdom

  • Futuremeds-Newcastle

    RECRUITING

    Newcastle, NE6 1SG, United Kingdom

  • G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.

    NOT_YET_RECRUITING

    Québec, G1V 4K5, Canada

  • GCM Medical Group, PSC - Hato Rey Site

    RECRUITING

    San Juan, 00917, Puerto Rico

  • Go Centro Medico San Nicolás

    NOT_YET_RECRUITING

    San Nicolás, 2900, Argentina

  • Goto Orthopedic Surgery Clinic

    RECRUITING

    Miyazaki, 880-0835, Japan

  • Great Lakes Clinical Trials - Ravenswood

    RECRUITING

    Chicago, Illinois, 60640, United States

  • HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T

    RECRUITING

    Hamburg, 20095, Germany

  • Hallym University Kangnam Sacred Heart Hospital

    RECRUITING

    Seoul, 07441, South Korea

  • Hospital das Clinicas FMUSP

    SUSPENDED

    São Paulo, 05403-000, Brazil

  • Huashan Hospital, Fudan University

    RECRUITING

    Shanghai, 200040, China

  • IBPClin - Instituto Brasil de Pesquisa Clínica

    SUSPENDED

    Rio de Janeiro, 20241-180, Brazil

  • INECO Neurociencias Oroño

    NOT_YET_RECRUITING

    Rosario, 2000, Argentina

  • INREA s.r.o.

    RECRUITING

    Ostrava, 70300, Czechia

  • INTEGRA - Pesquisa Clínica e Infusões

    SUSPENDED

    São Paulo, 04039-002, Brazil

  • Ibaraki Seinan Medical Center Hospital

    RECRUITING

    Sashima, 306-0433, Japan

  • Instituto Especialidades de la Salud Rosario

    NOT_YET_RECRUITING

    Rosario, 2000, Argentina

  • Instituto de Alta Complejidad San Isidro

    NOT_YET_RECRUITING

    San Isidro, 1642, Argentina

  • JCCT - Juno Bellaire Site

    RECRUITING

    Bellaire, Texas, 77401, United States

  • Jiangsu Province Hospital

    RECRUITING

    Nanjing, 210029, China

  • Jilin Province People's Hospital

    RECRUITING

    Changchun, 130021, China

  • Jinan Central Hospital

    RECRUITING

    Jinan, 250013, China

  • Katsura Garden Orthopedics

    RECRUITING

    Sendai, 981-3134, Japan

  • Keimyung University Dongsan Hospital

    RECRUITING

    Daegu, 42601, South Korea

  • Keystone Clinical Studies

    RECRUITING

    Plymouth Meeting, Pennsylvania, 19462, United States

  • Komagidai Clinic

    RECRUITING

    Nagareyama, 270-0113, Japan

  • Kormont

    RECRUITING

    Kluisbergen, 9690, Belgium

  • Maple Leaf Research

    RECRUITING

    Toronto, M5G 1K2, Canada

  • Masumoto Orthopedics Clinic

    RECRUITING

    Suginami City, 167-0051, Japan

  • Meclinas

    RECRUITING

    Mechelen, 2800, Belgium

  • Medical Plus Research

    RECRUITING

    Uherské Hradiště, 686 01, Czechia

  • Medical Research Partners

    RECRUITING

    Ammon, Idaho, 83406, United States

  • Medicina Reumatológica

    NOT_YET_RECRUITING

    San Fernando, 1646, Argentina

  • Medisch Centrum Latem (Hip Clinic) - Algemeen Ziekenhuis Maria Middelares Location

    NOT_YET_RECRUITING

    Sint-Martens-Latem, 9830, Belgium

  • Monroe Biomedical Research - Louisville

    RECRUITING

    Louisville, Kentucky, 40213, United States

  • NYC Research INC

    RECRUITING

    Long Island City, New York, 11106, United States

  • Nanjing First Hospital

    RECRUITING

    Nanjing, 210006, China

  • National Cheng Kung University Hospital

    RECRUITING

    Tainan, 704, Taiwan

  • National Hospital Organization Chiba Medical Center

    RECRUITING

    Chiba, 260-8606, Japan

  • National Hospital Organization Toyohashi Medical Center

    RECRUITING

    Toyohashi, 440-8510, Japan

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 10002, Taiwan

  • Ogura Orthopedics Surgery

    RECRUITING

    Sendai, 980-0011, Japan

  • Ooimachi Orthopedic Surgery and surgery Clinic

    RECRUITING

    Shinagawa-ku Tokyo, 140-0014, Japan

  • Organizacion Medica de Investigacion

    NOT_YET_RECRUITING

    Buenos Aires, C1015ABO, Argentina

  • Orita Clinical Research

    RECRUITING

    Decatur, Georgia, 30034, United States

  • Panthera Biopartners - Sheffield

    RECRUITING

    Sheffield, S2 5FX, United Kingdom

  • Panthera Clinic - York

    RECRUITING

    York, YO24 4LJ, United Kingdom

  • Paramount Clinical Research - Data Point Clinical Research

    RECRUITING

    Kirkland, Washington, 98034, United States

  • Pratia Brno

    RECRUITING

    Brno, 602 00, Czechia

  • Pratia Pardubice a.s.

    RECRUITING

    Pardubice, 53002, Czechia

  • Private Practice - Dr. Kai Könemann & Dr. Henrik Könemann

    RECRUITING

    Bünde, 32257, Germany

  • Qualmedica Research, LLC

    RECRUITING

    Evansville, Indiana, 47715, United States

  • Reuma Clinic, Locatie Jaarbeurslaan

    RECRUITING

    Genk, 3600, Belgium

  • Revmatologie.s.r.o.

    RECRUITING

    Brno, 63800, Czechia

  • Rochester Clinical Research - Buffalo

    RECRUITING

    Buffalo, New York, 14127, United States

  • Rochester Clinical Research, LLC

    RECRUITING

    Rochester, New York, 14609, United States

  • Saitama City Hospital

    RECRUITING

    Saitama, 336-8522, Japan

  • Sanos Clinic

    RECRUITING

    Herlev, 2730, Denmark

  • Sanos Clinic - Nordjylland

    RECRUITING

    Gandrup, 9362, Denmark

  • Sanos Clinic - Syddanmark

    RECRUITING

    Vejle, 7100, Denmark

  • Seoul National University Hospital

    RECRUITING

    Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    RECRUITING

    Seoul, 03722, South Korea

  • Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine

    RECRUITING

    Shanghai, 200023, China

  • Shin Komonji Hospital

    RECRUITING

    Kitakyushu-Shi, 800-0057, Japan

  • Siteworks GmbH - Bochum

    RECRUITING

    Bochum, 44787, Germany

  • Siteworks GmbH - Zentrum für klinische Studien Karlsruhe

    RECRUITING

    Karlsruhe, 76137, Germany

  • Skylight Health Research - Burlington

    RECRUITING

    Burlington, Massachusetts, 01803, United States

  • Skylight Health Research - Colorado Springs

    RECRUITING

    Colorado Springs, Colorado, 80917, United States

  • Stat Research S.A.

    NOT_YET_RECRUITING

    Buenos Aires, C1023AAB, Argentina

  • Stouffville Medical Research Institute Inc.

    RECRUITING

    Stouffville, L4A 1H2, Canada

  • StudyPoint Duisburg

    RECRUITING

    Duisburg, 47269, Germany

  • Taipei Medical University Hospital

    RECRUITING

    Taipei, 110, Taiwan

  • Texas Valley Clinical Research

    RECRUITING

    Weslaco, Texas, 78596, United States

  • The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University

    NOT_YET_RECRUITING

    Wenzhou, 315100, China

  • The Catholic Univ. of Korea Seoul St. Mary's Hospital

    RECRUITING

    Seoul, 06591, South Korea

  • The Catholic University of Korea, Uijeongbu St. Mary's Hospital

    RECRUITING

    Uijeongbu-si, 11765, South Korea

  • The First Affiliated Hospital of Henan University of Science &Technology

    RECRUITING

    Luoyang, 471003, China

  • The First Afflilated Hospital of Bengbu Medical College

    RECRUITING

    Bengbu, 233004, China

  • The Second Affiliated Hospital of Nanjing Medical University

    RECRUITING

    Nanjing, 210011, China

  • The Second Affiliated Hospital of Soochow University

    RECRUITING

    Suzhou, 215004, China

  • The Second Affiliated hospital of Zhejiang University school of medicine

    RECRUITING

    Hangzhou, 310052, China

  • The Second Hospital of Jilin University

    NOT_YET_RECRUITING

    Changchun, 130041, China

  • The Second People's Hospital of Hefei

    RECRUITING

    Hefei, 230011, China

  • The first affiliated hospital of Ningbo university

    RECRUITING

    Ningbo, 315010, China

  • Tianjin Hospital

    RECRUITING

    Tianjin, 300211, China

  • Tokyo Asbo Clinic

    RECRUITING

    Chūōku, 104-0031, Japan

  • Tokyo-Eki Center-building Clinic

    RECRUITING

    Chūōku, 103-0027, Japan

  • Tongji Hospital Tongji Medical,Science & Technology

    RECRUITING

    Wuhan, 430030, China

  • Tri-Service General Hospital

    RECRUITING

    Taipei, 114, Taiwan

  • Tucson Orthopaedic Institute - North Wyatt Drive

    RECRUITING

    Tucson, Arizona, 85712, United States

  • UZ Gent

    RECRUITING

    Ghent, 9000, Belgium

  • UZ Leuven

    RECRUITING

    Leuven, 3000, Belgium

  • VIP Trials

    RECRUITING

    San Antonio, Texas, 78230, United States

  • Valley Institute of Research - Fort Worth

    RECRUITING

    Fort Worth, Texas, 76164, United States

  • Velocity Clinical Research, Bristol

    RECRUITING

    Bristol, BS8 2RA, United Kingdom

  • Westside Center for Clinical Research

    RECRUITING

    Jacksonville, Florida, 32205, United States

  • Wolverine Clinical Trials

    RECRUITING

    Santa Ana, California, 92706, United States

  • Woodstock Bower Surgery

    RECRUITING

    Rotherham, S61 1AH, United Kingdom

  • Xiangya Hospital Central South University

    RECRUITING

    Changsha, 410008, China

  • Xianyang Hospital of Yan'an University

    RECRUITING

    Xianyang, 712000, China

  • Yamagata Tokushukai Hospital

    RECRUITING

    Yamagata, 990-0834, Japan

  • ZNA Jan Palfijn

    NOT_YET_RECRUITING

    Merksem, 2170, Belgium

  • Zhongda Hospital Southeast University

    RECRUITING

    Nanjing, 210009, China

  • Zhongshan Hospital,Fudan University

    RECRUITING

    Shanghai, 200032, China

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