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New hope for kidney patients: experimental drug takes on standard therapy

NCT ID NCT07204275

Disease control Sponsor: Vertex Pharmaceuticals Incorporated Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 18, 2026 · Updated 9 times

Summary

This study tests a new drug, povetacicept, against a standard treatment (calcineurin inhibitor) in 176 adults with primary membranous nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the new drug can put the disease into remission more safely and effectively. Participants will be randomly assigned to one of the two treatments and monitored for side effects and remission rates.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 176 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: • Diagnosed with pMN with confirmatory historical biopsy. If no historical biopsy was performed that confirmed pMN, a biopsy can be performed during Screening to confirm eligibility Key Exclusion Criteria: • Hypersensitivity to investigational medicinal product or to any of its excipients Other protocol defined Inclusion/Exclusion criteria will apply

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

idiopathic membranous glomerulonephritis membranous glomerulonephritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Primary membranous nephropathy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    114 sites in 14 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AOU Consorziale Policlinico di Bari - Nefrologia, Dialisi e Trapianti

    RECRUITING

    Bari, Italy

  • Academic Medical Research Institute (AMRI)

    RECRUITING

    Los Angeles, California, 90022, United States

  • Amsterdam UMC - Nephrology

    RECRUITING

    Amsterdam, Netherlands

  • Azienda Ospedaliera Universitaria Federico II

    RECRUITING

    Naples, Italy

  • Beaumont Hospital

    RECRUITING

    Dublin, Ireland

  • Beijing Tsinghua Changgung Hospital

    RECRUITING

    Beijing, China

  • Bioresearch Partner

    RECRUITING

    Miami, Florida, 33127, United States

  • CARE Institute-Boise Kidney

    RECRUITING

    Boise, Idaho, 83706, United States

  • CTR Oakwater, LLC

    RECRUITING

    Orlando, Florida, 32806, United States

  • Carolina Nephrology Greenville

    RECRUITING

    Greenville, South Carolina, 29605, United States

  • Carolina Nephrology, PA

    RECRUITING

    Spartanburg, South Carolina, 29306, United States

  • Charite - Universitaetsmedizin Berlin Campus Benjamin Frankl

    RECRUITING

    Allemagne, Germany

  • Clinica Universidad de Navarra - Nefrología

    RECRUITING

    Pamplona, Spain

  • Clinical Site Partners, LLC - Orlando

    RECRUITING

    Winter Park, Florida, 32789, United States

  • Concord Repatriation General Hospital

    RECRUITING

    Concord, Australia

  • Cork University Hospital - Nephrology

    RECRUITING

    Cork, Ireland

  • DaVita Clinical Research Columbus

    RECRUITING

    Columbus, Georgia, 31904, United States

  • DaVita Clinical Research Edina

    RECRUITING

    Edina, Minnesota, 55435, United States

  • DaVita Clinical Research Houston

    RECRUITING

    Houston, Texas, 77054, United States

  • Dalian Municipal Central Hospital

    RECRUITING

    Dalian, China

  • Davita Clinical Research San Antonio

    RECRUITING

    San Antonio, Texas, 78251, United States

  • Doncaster and Bassetlaw Hospitals NHS Foundation Trust - Doncaster Royal Infirmary

    RECRUITING

    Doncaster, United Kingdom

  • Dongguan People's Hospital

    RECRUITING

    Dongguan, China

  • El Paso Kidney Specialists

    RECRUITING

    El Paso, Texas, 79902, United States

  • FN Kralovske Vinohrady - Interni klinika

    RECRUITING

    Prague, Czechia

  • Fondazione IRCCS Policlinico San Matteo

    RECRUITING

    Pavia, Italy

  • Fondazione Salvatore Maugeri - Nefrologia e Dialisi

    RECRUITING

    Pavia, Italy

  • Freire Pesquisa Clinica

    RECRUITING

    Belo Horizonte, Brazil

  • Fujita Health University

    RECRUITING

    Toyoake-Shi, Japan

  • Fundação Bahiana de Infectologia

    RECRUITING

    Salvador, Brazil

  • Fuyang People's Hospital

    RECRUITING

    Fuyang, China

  • Georgia Nephrology

    RECRUITING

    Lawrenceville, Georgia, 30046, United States

  • Guangdong Provincial People's Hospital

    RECRUITING

    Guangzhou, China

  • Hallym University Sacred Heart Hospital

    RECRUITING

    Anyang-si, South Korea

  • Hospital Ribera Polusa

    RECRUITING

    Lugo, Spain

  • Hospital Universitari Vall D Hebron

    RECRUITING

    Barcelona, Spain

  • Hospital Universitario Reina Sofia

    RECRUITING

    Córdoba, Spain

  • Hospital Universitario Virgen de la Macarena - Nefrología

    RECRUITING

    Seville, Spain

  • Hospital das Clinicas da Faculdade de Medicina da USP - HC- FMUSP

    RECRUITING

    São Paulo, Brazil

  • Hospital de Vinalopó

    RECRUITING

    Elche, Spain

  • IRCCS Ospedale Policlinico San Martino

    RECRUITING

    Genova, Italy

  • Imperial College Healthcare NHS Trust - Hammersmith Hospital

    RECRUITING

    London, United Kingdom

  • Juntendo University Urayasu Hospital

    RECRUITING

    Urayasu, Japan

  • Kaiser Permanente Sacramento Medical Center

    RECRUITING

    Sacramento, California, 95825, United States

  • Kanazawa University Hospital

    RECRUITING

    Kanazawa, Japan

  • Kasugai Municipal Hospital

    RECRUITING

    Kasugai, Japan

  • Kidney Specialists of Southern Nevada

    RECRUITING

    Las Vegas, Nevada, 89107, United States

  • Klinikum St. Georg gGmbH - Nephrology

    RECRUITING

    Leipzig, Germany

  • Korea University Anam Hospital - Nephrology

    RECRUITING

    Seoul, South Korea

  • Korea University Guro Hospital - Nephrology

    RECRUITING

    Seoul, South Korea

  • Kyung Hee University Hospital at Gangdong - Nephrology

    RECRUITING

    Seoul, South Korea

  • Liu Zhou Works Hospital

    RECRUITING

    Liuzhou, China

  • Milwaukee Neprologists, SC

    RECRUITING

    Wauwatosa, Wisconsin, 53226, United States

  • Monash Medical Centre

    RECRUITING

    Clayton, Australia

  • NANI Research

    RECRUITING

    Hinsdale, Illinois, 60521, United States

  • NHS Lothian - Royal Infirmary of Edinburgh

    RECRUITING

    Edinburgh, United Kingdom

  • NYU Medical Center

    RECRUITING

    New York, New York, 10016-9196, United States

  • Nagoya University Hospital

    RECRUITING

    Shōwaku, Japan

  • Nanyang Central Hospital

    RECRUITING

    Nanyang, China

  • Nephrology Associates of Northern Illinois and Indiana (NANI) - Indianapolis South

    RECRUITING

    Indianapolis, Indiana, 46227, United States

  • Northwest Louisiana Nephrology, LLC - Shreveport

    RECRUITING

    Shreveport, Louisiana, 71101, United States

  • Okayama University Hospital

    RECRUITING

    Okayama, Japan

  • Peking University First Hospital

    RECRUITING

    Beijing, China

  • Provecta Research Network

    RECRUITING

    Houston, Texas, 77027, United States

  • Radboud universitair medisch centrum / RADBOUDUMC - Nephrology

    RECRUITING

    Nijmegen, Netherlands

  • Renal Associates

    RECRUITING

    Montgomery, Alabama, 36117, United States

  • Renji Hospital Shanghai Jiaotong University School of Medicine

    RECRUITING

    Shanghai, China

  • Samsung Medical Center - Nephrology

    RECRUITING

    Seoul, South Korea

  • Santa Casa de Misericordia

    RECRUITING

    Porto Alegre, Brazil

  • Severance Hospital, Yonsei University Health System - Nephrology

    RECRUITING

    Seoul, South Korea

  • Shanghai General Hospital

    RECRUITING

    Shanghai, China

  • Shenjing Hospital of China Medical University

    RECRUITING

    Shenyang, China

  • Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People's Hospital

    RECRUITING

    Chengdu, China

  • Southwest Kidney Institute, PLC (SKI) - Surprise

    RECRUITING

    Surprise, Arizona, 85374, United States

  • St George Private Hospital

    RECRUITING

    Kogarah, Australia

  • St George's University Hospitals NHS Foundation Trust - St George's Hospital- Renal Medicine

    RECRUITING

    London, United Kingdom

  • St. Clair Nephrology Research

    RECRUITING

    Roseville, Missouri, 48066, United States

  • St. Vincent'S University Hospital

    RECRUITING

    Dublin, Ireland

  • St.Marianna University School of Medicine Hospital

    RECRUITING

    Kawasaki-shi, Japan

  • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

    RECRUITING

    Szeged, Hungary

  • Tai'an City Central Hosptial

    RECRUITING

    Tai’an, China

  • The 2nd Affiliated Hospital of Harbin Medical University

    RECRUITING

    Harbin, China

  • The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University

    RECRUITING

    Huai'an, China

  • The First Affiliated Hospital of Baotou Medical College

    RECRUITING

    Baotou, China

  • The First Affiliated Hospital of Bengbu Medical University

    RECRUITING

    Bengbu, China

  • The First Affiliated Hospital of Nanchang University

    RECRUITING

    Nanchang, China

  • The First Affiliated Hospital of Ningbo University

    RECRUITING

    Ningbo, China

  • The First Affiliated Hospital of Xi 'an Jiaotong University

    RECRUITING

    Xi'an, China

  • The First Affiliated Hospital of Xiamen University

    RECRUITING

    Xiamen, China

  • The First Affiliated Hospital,Sun Yat-sen University

    WITHDRAWN

    Guangzhou, China

  • The First Hospital of Hebei Medical University

    RECRUITING

    Shijiazhuang, China

  • The Fourth Hospital of Hebei Medical University

    RECRUITING

    Shijiazhuang, China

  • The Fourth Hospital of Hebei Medical Univesrsity

    RECRUITING

    Shijiazhuang, China

  • The People's Hospital of Guangxi Zhuang Autonomous Region

    RECRUITING

    Nanning, China

  • The Royal Wolverhampton NHS Trust - New Cross Hospital

    RECRUITING

    Wolverhampton, United Kingdom

  • The Second Hospital of Hebei Medical University

    RECRUITING

    Shijiazhuang, China

  • The Second Norman Bethune Hospital of Jilin University

    RECRUITING

    Changchun, China

  • The Second Qilu Hospital of Shandong University

    RECRUITING

    Jinan, China

  • The University of Osaka Hospital

    RECRUITING

    Suita, Japan

  • Universidade Federal de Pernmabuco

    RECRUITING

    Recife, Brazil

  • Universitaetsklinikum Leipzig - Medizinische Klinik und Poliklinik III - Klinik und Poliklinik fuer Endokrinologie, Nephrologie

    RECRUITING

    Leipzig, Germany

  • Universitaetsklinikum Wuerzburg - Innere Medizin, Nephrologie

    RECRUITING

    Würzburg, Germany

  • University Hospital Galway

    RECRUITING

    Galway, Ireland

  • University Hospital of Derby and Burton NHS Foundation Trust - Royal Derby Hospital

    RECRUITING

    Derby, United Kingdom

  • University of Newcastle - John Hunter Hospital (JHH)

    RECRUITING

    New Lambton Heights, Australia

  • Utah Kidney Research

    RECRUITING

    Salt Lake City, Utah, 84115, United States

  • Valiance Clinical Research - Internal Medicine

    RECRUITING

    Tarzana, California, 91356, United States

  • Vseobecna fakultni nemocnice v Praze - Klinika nefrologie

    RECRUITING

    Prague, Czechia

  • Weifang People's Hospital

    RECRUITING

    Weifang, China

  • Western Nephrology & Metabolic Bone Disease PC

    RECRUITING

    Arvada, Colorado, 80002, United States

  • Wuxi People's Hospital

    RECRUITING

    Wuxi, China

  • Xiangya Hospital of Central South University

    RECRUITING

    Changsha, China

  • Yantai YuHuangDing Hospital

    RECRUITING

    Yantai, China

  • Yichang Central People Hospital

    RECRUITING

    Yichang, China

  • Yongin Severance Hospital - Nephrology

    RECRUITING

    Yongin-si, South Korea

More trials for these conditions

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