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Can a High-Speed eye scan catch silent blinding disease in kids?

NCT ID NCT07813598

Diagnosis Sponsor: Sheffield Children's NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 16, 2026 · Updated 3 times

Summary

Uveitis is an inflammation inside the eye that can cause permanent vision loss in children, often without symptoms. This study compares a high-resolution, non-contact eye scan called AS-OCT with the standard slit-lamp eye exam in 300 children aged 2 to 16 who attend a pediatric uveitis clinic. Researchers will use automated algorithms to analyze the scans and see if they can detect and measure inflammatory cells as accurately as the standard exam. The goal is to develop a cost-effective, automated tool for diagnosing and monitoring uveitis over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Anterior segment ocular coherence tomography (AS-OCT)
What this could lead to
If the scan matches standard exams, it could give doctors an automated, objective way to catch and track childhood uveitis earlier, especially when symptoms are absent.
What could go wrong
The study is observational and early-stage, so it may not prove the scan is accurate enough for routine use. Children still need standard eye exams during the study.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2026

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Paediatric patients at Sheffield Children's Hospital, who have been referred to the clinics for uveitis and JIA-uveitis.

Ages

2 to 16 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged between 2 and 16 years * Attending uveitis and JIA-uveitis clinic at Sheffield Children's Hospital * Parents/carers give informed written consent and CYP give age-appropriate assent Exclusion Criteria: * Unable to obtain parental/carer written consent * CYP does not want to be recruited

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Conditions

The condition(s) this trial relates to.

non-infectious anterior uveitis uveitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Uveitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sheffield Children's Hospital

    RECRUITING

    Sheffield, South Yorkshire, S10 2TH, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.