Can a High-Speed eye scan catch silent blinding disease in kids?
NCT ID NCT07813598
First seen Sep 10, 2026 · Last updated Sep 16, 2026 · Updated 3 times
Summary
Uveitis is an inflammation inside the eye that can cause permanent vision loss in children, often without symptoms. This study compares a high-resolution, non-contact eye scan called AS-OCT with the standard slit-lamp eye exam in 300 children aged 2 to 16 who attend a pediatric uveitis clinic. Researchers will use automated algorithms to analyze the scans and see if they can detect and measure inflammatory cells as accurately as the standard exam. The goal is to develop a cost-effective, automated tool for diagnosing and monitoring uveitis over time.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Anterior segment ocular coherence tomography (AS-OCT)
- What this could lead to
- If the scan matches standard exams, it could give doctors an automated, objective way to catch and track childhood uveitis earlier, especially when symptoms are absent.
- What could go wrong
- The study is observational and early-stage, so it may not prove the scan is accurate enough for routine use. Children still need standard eye exams during the study.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 300 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2026
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Paediatric patients at Sheffield Children's Hospital, who have been referred to the clinics for uveitis and JIA-uveitis.
- Ages
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2 to 16 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged between 2 and 16 years * Attending uveitis and JIA-uveitis clinic at Sheffield Children's Hospital * Parents/carers give informed written consent and CYP give age-appropriate assent Exclusion Criteria: * Unable to obtain parental/carer written consent * CYP does not want to be recruited
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Sheffield Children's Hospital
RECRUITINGSheffield, South Yorkshire, S10 2TH, United Kingdom
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