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Could a poop pill help heal after colon surgery?

NCT ID NCT06370884

Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 3 times

Summary

This early study is testing whether giving a transplant of healthy gut bacteria (called IMT) through a feeding tube is safe and doable in 40 adults who have had part of their colon removed due to diverticulitis or sigmoid colon cancer. Participants get the transplant a couple of days after surgery and are followed for up to 6 months to check for side effects and changes in their gut microbiome. The goal is to see if this approach is safe enough to study further for preventing infections like recurrent C. diff.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intestinal microbiota transplant (IMT) solution
What this could lead to
If it works, this could point toward a way to restore healthy gut bacteria after colon surgery and reduce complications like recurrent C. diff infection.
What could go wrong
This is a very early Phase 1 pilot study with only 40 people, so it is designed just to test safety and feasibility, not effectiveness. There is a small risk of bowel perforation from the feeding tube, and the transplant may not engraft or provide benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2024

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Able/willing to provide informed consent * Between 18-75 years of age * Undergoing surgery for a history of diverticulitis or sigmoid colon cancer. * Able to provide fecal samples * Stated willingness to comply with all study procedures and availability for the duration of trial to follow-up by telephone, in-person, email, and/or video visits or correspondence Exclusion Criteria: * Any history of inflammatory bowel disease * Pregnancy or breastfeeding. A pregnancy test will be obtained from females of child- bearing potential on the proposed day of IMT (prior to the receipt of IMT). Patients with a positive pregnancy test will be excluded. A negative result will be required for subjects who are females of child-bearing potential to receive IMT treatment. * Life expectancy of \< 6 months * Presence of ileostomy or colostomy * Known history of inflammatory bowel disease (Crohn's, Ulcerative Colitis) * Patients on immunosuppressants (calcineurin inhibitors, prednisone ≥ 20 mg/day, methotrexate, azathioprine, immunosuppressive biologics, JAK inhibitors) * Patients with neutropenia (an absolute neutrophil count \< 0.5 x 109 cells/L) obtained on a complete blood count with differential at screening. * History of solid organ or bone marrow transplant. * Anticipated recurrent antibiotic use (e.g., patients with frequent urinary tract infections or sinusitis). * History of severe anaphylactic food allergy. * History of celiac disease. * Patients receiving cancer chemotherapy, immunotherapy, or radiation.

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Conditions

The condition(s) this trial relates to.

Clostridium difficile colitis Clostridium infectious disease diverticulitis sigmoid colon cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colonic surgery Recurrent clostridioides difficile infection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Minnesota

    RECRUITING

    Minneapolis, Minnesota, 55414, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.