University Of Minnesota

This study tests a mobile health program called mGlide-Care to help manage high blood pressure in people with mild cognitive impairment or early Alzheimer's disease. Participants work with a family caregiver to use a smartphone app and blood pressure monitor. The goal is to see i…

This study tests a method to optimize settings for epidural spinal cord stimulation in people with complete paralysis from a spinal cord injury. The goal is to help them regain voluntary leg movement and improve functions like blood pressure control. The study enrolls 100 adults …

This study tests new drug combinations for cryptococcal meningitis, a brain infection that is always fatal without treatment and still kills many people with HIV. The trial aims to find safer and more effective therapies by comparing several new antifungal regimens. About 2,000 a…

This study tests whether transplanting healthy gut bacteria (microbiota transplant therapy) can help people with moderate to severe alopecia areata regrow hair. About 40 adults aged 18-75 with patchy or total hair loss will receive the treatment. Researchers will track changes in…

This study looks at whether empagliflozin, a drug originally for diabetes, can improve heart function in 80 older adults with high blood pressure and obesity who are at risk for heart failure. Participants will take either the drug or a placebo daily for 9 months. The goal is to …

This study tests whether long-term electrical stimulation of the spinal cord can help people with chronic spinal cord injuries regain voluntary movement. Researchers will measure changes in muscle activity with and without stimulation. The study enrolls 50 adults with stable spin…

This study tests whether adding weight-loss surgery (vertical sleeve gastrectomy) to lifestyle changes is more effective than lifestyle changes alone for people with NASH, a serious liver condition. About 48 adults aged 30-70 with NASH and obesity will be randomly assigned to one…

This study looks at whether weighing yourself every day can help teens aged 12 to 18 with obesity manage their weight. About 99 teens will be split into three groups: usual care, usual care plus a simple scale, or usual care plus a smart scale that connects to their doctor. Resea…

This study explores whether a culturally tailored sleep program can help African American adults who sleep 6 hours or less and have overweight or obesity. The goal is to increase sleep and physical activity to reduce obesity-related health risks. The research has two phases: firs…

This study looks at whether taking antibiotics after bladder removal surgery helps prevent urinary tract infections. About 120 adults with muscle-invasive bladder cancer will be randomly assigned to receive either an antibiotic or no antibiotic after surgery. The goal is to see i…

This study compares two surgical options for people with large, irreparable rotator cuff tears. One procedure smooths the bone (tuberoplasty), the other places a small balloon under the shoulder (balloon spacer). Researchers will use special X-rays to see how the shoulder moves a…

This study looks at whether using a flash continuous glucose monitor (CGM) can help children and young adults in Uganda with type 1 diabetes keep their blood sugar in a healthy range more often than the usual finger-prick tests. About 180 participants will be split into two group…

This study aims to improve walking and balance in 60 people with Parkinson's disease who already have a brain implant (deep brain stimulation). Researchers will use MRI and CT scans to create a computer model of each patient's brain and then find the best stimulation settings to …

This study tests whether a special breathing exercise called Inspiratory Muscle Strength Training (IMST) can lower blood pressure in adults with high systolic blood pressure. About 144 participants will do one of three levels of IMST for 6 weeks. The goal is to see if stronger br…

This study looks at whether giving probiotics to pregnant women with diabetes can improve their babies' brain development. The researchers will measure how babies' brains respond to sounds and images at 1 and 6 months old. The study involves 60 pregnant women in their second or t…

This study tests whether a soft, FDA-approved belly band can help premature babies on breathing support develop stronger stomach muscles. Researchers will measure muscle thickness with ultrasound and see if babies reach full oral feeding earlier. The study involves 40 premature i…

This early study tests whether an oral treatment made from gut bacteria is safe and doable for people with primary sclerosing cholangitis (PSC), a rare liver disease. About 28 adults aged 18-76 will take the therapy and be monitored for side effects and completion of the full cou…

This study tests whether a drug called fisetin can reduce organ failure in older adults (65+) with mild sepsis. Sepsis is a severe response to infection that can damage organs. The drug targets aging cells that may make the body's response worse. The trial will compare two doses …

This study tests whether a single infusion of concentrated antibodies against COVID-19 can help adults with early, mild COVID-19 avoid severe illness. About 820 participants aged 55+ or with weakened immune systems will receive either the antibody treatment or a placebo. The goal…

This early-phase trial tests whether a 28-day course of two oral drugs (mirdametinib and vorinostat) can safely shrink or change a rare, aggressive nerve sheath tumor in people with neurofibromatosis type 1 (NF1). Up to 8 participants aged 12 and older will receive the drugs befo…

This study tests whether a combination of two diabetes drugs (pioglitazone and metformin) can shrink or improve precancerous patches in the mouth called oral leukoplakia. About 36 adults with high-risk lesions will take the pills twice daily for 12 weeks. The goal is to see if th…

This study tests whether pairing a gentle electrical brain stimulation (tDCS) with computer-based cognitive training can help people with alcohol use disorder stay abstinent longer. About 40 participants who are already sober and in a residential program will receive the combined…

This study looks at how long new mothers with high blood pressure should monitor their blood pressure from home after giving birth. Researchers will compare a 2-week program with a 6-week program to see which leads to better blood pressure control at the 6-week checkup. About 400…

This study tests whether an implanted spinal cord stimulator can safely improve blood pressure, heart rate, and overall function in people with chronic cervical spinal cord injury. It involves 36 adults with stable, motor-complete injuries between the C4 and C7 vertebrae. The mai…

This study looks at whether a non-invasive brain stimulation technique called tDCS, combined with computer-based cognitive training, can help people with opioid use disorder who are already on buprenorphine maintenance. Researchers will measure changes in brain connectivity and t…

This study is testing whether transplanting healthy gut bacteria (in capsule form) can take hold in the intestines of people with Crohn's disease and possibly reduce inflammation. Researchers will enroll 120 adults with active Crohn's to see if the donor microbes engraft and if s…

This study tests a new way to train youth mentors and their supervisors to deliver a proven depression prevention program to teens in rural communities. About 96 teens aged 12-17 and their parents, along with mentors and supervisors, will take part. The goal is to see if the trai…

This study is testing whether a drug called CMVIG can prevent CMV infection in kidney transplant patients who are switching to a new anti-rejection medicine (belatacept). About 30 adults who are CMV-negative but received a kidney from a CMV-positive donor will take part. Research…

This study tests whether the drug bupropion can help women who quit smoking during pregnancy stay smoke-free after giving birth. About 200 women will receive either bupropion or a placebo for 12 weeks after delivery. Researchers will track their smoking status through questionnai…

This study tests three school-based programs to help high school students who are at risk for conduct problems like defiance or rule-breaking. About 120 students will be randomly assigned to a mindfulness program, a mindfulness program with a mobile app, or a life skills program.…

This study looks at whether testing for and treating Staphylococcus aureus (S. aureus) bacteria before surgery can prevent infections after the operation. About 250 adults having outpatient surgery will be split into four groups, each using different combinations of nasal ointmen…

This study tests whether people with central vision loss from age-related macular degeneration can read faster and more accurately when missing text is remapped to other parts of their visual field. About 108 participants will try different remapping techniques while their readin…

This study tests if freezing the nerves between the ribs (cryoablation) provides better pain control a week later than a standard numbing catheter placed near the spine. About 48 adults with multiple broken ribs will be randomly assigned to one of the two treatments. The main goa…

This study tests a culturally adapted program called ACES for Black immigrant caregivers of people with dementia. The program aims to reduce caregiver stress, depression, and burden while improving quality of life. About 150 care partners and their loved ones will participate, wi…

This study compares two different settings for deep brain stimulation (DBS) in people with Parkinson's disease. The goal is to see which setting improves walking and balance more. Thirty adults who already have DBS implants will be tested with both settings to find the best optio…

This study looks at whether adding a pectoserratus nerve block to the standard interscalene block can better control pain and reduce opioid use after total shoulder replacement. About 110 adults having shoulder replacement will be randomly assigned to get either the extra block w…

This study looks at whether taking a probiotic supplement for 5 weeks can help reduce muscle soreness after exercise in healthy, active young adults. Researchers will measure pain, pressure sensitivity, and jump performance. The goal is to see if probiotics can speed up recovery …

This study tests a telehealth program that trains community providers to coach parents of children with autism. The goal is to improve child communication and behavior while reducing parent stress. About 90 families will participate, including those in remote areas or military fa…

This study tests whether adding a gentle brain stimulation technique (TMS) to standard behavioral therapy (CBIT) can help teenagers with chronic tics or Tourette syndrome suppress their tics better. About 60 participants aged 12–21 will receive both treatments, and researchers wi…

This study tests if freezing a specific nerve group (cryoablation) provides better pain control 30 days after hip fracture surgery compared to a standard nerve block (fascia iliaca catheter). About 150 adults aged 18-85 having hip fracture repair will take part. The goal is to se…

This study tests whether a computer-delivered therapy can help people who have both an anxiety disorder and alcohol use disorder. The program aims to reduce heavy drinking days and delay relapse. Researchers will enroll 256 adults in an addiction treatment program to see if this …

This study looks at whether increasing the heart rate using an existing pacemaker can improve heart failure symptoms and exercise ability in people with cardiac amyloidosis. Ten adults with a pacemaker and this heart condition will be monitored. The goal is to see if a simple pac…

This study tests whether a numbing injection near a nerve cluster in the neck can lower the chance of a common irregular heartbeat (atrial fibrillation) after lung or esophagus surgery. About 48 adults having these surgeries will receive either the nerve block or standard care. T…

This study tests whether a one-week practice of alternate nostril breathing can reduce nausea and vomiting in pregnant people during their first trimester. Researchers will compare symptom changes between those who do the breathing exercise and those who don't. The goal is to fin…

This study tests whether a gentle brain stimulation technique (tDCS) combined with computer-based cognitive training can improve thinking and reduce symptoms in people who have had a mild concussion 3 to 12 months ago. About 30 adults aged 18-65 with persistent post-concussion sy…

This early-phase study tests a new way to treat chronic pain using a type of brain stimulation called accelerated TMS. The method uses a smart algorithm to choose the best spot to stimulate for each person. The goal is to see if this personalized approach is safe and can reduce p…

This study compares two treatments for people with cancer that has spread to the spine. One group gets a procedure that uses heat to destroy tumor tissue and strengthens the bone, plus standard radiation. The other group gets radiation alone. The goal is to see if the combined ap…

This study tests whether a community-based exercise program can improve walking ability and heart health in people with peripheral artery disease (PAD) who have had a procedure to open blocked leg arteries. About 30 participants will take part. The goal is to see if this type of …

This study is testing a special soft cast for diabetic foot ulcers. Researchers want to see if it helps ulcers heal completely, is comfortable, and safe to use. The study will include 100 adults with diabetic foot ulcers. Participants will use the cast until their ulcer heals or …

This study tests two mobile app programs designed to help adults with binge eating disorders reduce their symptoms. Participants will use either a heart rate biofeedback app or guided body scan videos over 4 weeks. The goal is to see if improving body awareness can decrease binge…

This study looks at how the mind-body practice QiGong changes brain activity to help people with long-term low back pain. Researchers will measure pain levels, body awareness, and mindfulness in 60 adults who practice QiGong. The goal is to understand the brain mechanisms behind …

This study looks at whether a new method called ECAPS can improve spinal cord stimulation for people with chronic pain. Researchers will enroll 15 adults who already have spinal cord implants to see if the approach is practical and acceptable. The goal is to make pain management …

This study tests a new type of deep brain stimulation (DBS) for people with essential tremor, a condition that causes shaking hands. Instead of using constant high-energy pulses like standard DBS, the new method uses lower-energy patterns that may work better and have fewer side …

This study compares two common pain relief treatments for people with shoulder arthritis or rotator cuff problems: a steroid injection into the joint versus a nerve block near the shoulder blade. Researchers will track pain levels and shoulder function in 40 adults over time to s…

This study tests if a small, at-home device that sends mild electrical pulses to the ear can safely reduce jaw pain in people with temporomandibular disorder (TMD). About 40 adults with chronic jaw pain will use the device daily for several weeks. Researchers will measure pain le…

This study looks at a new method called 'telefitting' to fine-tune spinal cord stimulators for people with chronic back or leg pain. Participants will try different stimulation settings without knowing which one they are using, and a smart algorithm will pick the best option. The…

This study tests whether a gentle brain stimulation technique (tDCS) combined with computer-based thinking exercises can improve attention, memory, and problem-solving in children aged 8–17 with Fetal Alcohol Spectrum Disorders (FASD). About 70 kids will be randomly assigned to r…

This study tests if mild electrical stimulation on the brain's surface can help people with severe depression that hasn't improved with other treatments. About 15 participants will have a small device surgically placed under the scalp to deliver targeted pulses. The goal is to se…

This study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. It blocks abnormal blood vessels in the knee to reduce pain and improve function. Twenty adults aged 40–70 will be randomly assigned to get the procedure plus …

This study tests whether gentle vibrations on neck muscles can improve head posture in people with cervical dystonia, a condition causing abnormal head positioning. Fifty adults with the condition will receive different vibration intensities during a single 3-hour lab visit. Rese…

This study follows 52 people with Tay-Sachs, Sandhoff, or GM1 gangliosidosis to learn how these rare genetic diseases progress. Researchers measure changes in development, movement, and communication skills each year. No new treatments are given; the goal is to create a clear pic…

This study looks at how the brain's reward system changes when teenagers with cannabis use disorder stop using cannabis for 6 weeks. Researchers will use brain scans (fMRI) to compare teens who quit with those who keep using and with teens who never used cannabis. The goal is to …

This study measures specific blood markers of inflammation and oxidative stress in 34 adults with Gaucher disease type I. Researchers want to see if these markers can give a clearer picture of disease activity beyond current tests. Participants must be stable on their current the…

This study tests a new device that helps doctors steer catheters during heart rhythm tests or treatments in children. About 25 kids (up to age 21) already scheduled for a heart procedure will have the device used at the end. Researchers will check if it works safely and improves …

This study looks at how the brain's reward and threat systems may keep bulimia going. Researchers will use brain scans and daily mood surveys in 100 adults to see if anticipating food or purging triggers abnormal brain activity. The goal is to understand the underlying mechanisms…

This study looks at how different parts of the brain talk to each other to control movement in people with Parkinson's disease. During planned deep brain stimulation (DBS) surgery, researchers will place a thin strip of sensors on the brain's surface to record activity. The goal …

This study looks at why sepsis causes long-term immune system problems, making people more likely to get serious infections again. Researchers will study blood samples from 150 ICU patients with sepsis over 28 days. The goal is to find the root causes of immune dysfunction, not t…

This study looks at whether measuring nerve signals during a standard procedure for severe facial pain (trigeminal neuralgia) can help doctors map the pain more precisely. About 30 adults scheduled for this procedure will have their nerve signals recorded before and after treatme…

This study uses advanced MRI scans to understand how the brain and kidneys change as we age, and how these changes relate to thinking abilities. Healthy adults aged 18 and older will undergo MRI and cognitive tests. The goal is to gather knowledge, not to provide treatment.

This study looks at whether brain wave patterns can show if tinnitus (ringing in the ears) gets better after using a device that stimulates both sound and touch. Researchers will measure brain activity in 24 adults with tinnitus before and after six weeks of using the device. The…

This study looks at how the exact placement of deep brain stimulation (DBS) affects movement in people with Parkinson's disease. Researchers will test 24 adults who already have DBS implants to see which stimulation spots improve or worsen motor symptoms. The goal is to learn how…

This study aims to make it easier for doctors to set up deep brain stimulation (DBS) devices for people with essential tremor. Researchers will use computer models to predict which stimulation settings will work best, reducing the trial-and-error process. About 25 adults with ess…

This early-stage study tests whether a freeze-dried fecal transplant from healthy donors is safe and feasible for people having part of their colon removed. About 40 adults aged 18-75 with colon polyps, early-stage colon cancer, or diverticulitis will take the transplant by mouth…

This study looks at why some people with Parkinson's disease suddenly feel like their feet are glued to the floor, known as freezing of gait. Researchers will use special brain recordings from already-implanted devices to compare brain activity in people with and without this sym…

This early study tests whether taking a capsule of healthy gut bacteria (microbiota transplant) can change the gut microbiome in 16 adults with hidradenitis suppurativa, a chronic and painful skin condition. The goal is to see if these gut changes affect skin bacteria and possibl…

This study tests whether a special video camera that records the eye can measure pressure inside the brain without needles, anesthesia, or touching the eye. About 90 adults with or without brain pressure issues will participate. If successful, this could lead to a safer, simpler …

This study aims to identify brain chemical markers in adults with Type 3 Gaucher disease using a special MRI technique called magnetic resonance spectroscopy. Researchers will measure up to 18 brain metabolites to see if they can track disease activity and treatment response. Onl…

This study is testing a new type of dental MRI (ddMRI) to see if it is safe and useful for diagnosing dental problems. Researchers will compare the ddMRI images to standard dental X-rays and CT scans that participants already have. The goal is to see if the ddMRI can find issues …

This study is testing whether a special electrode placed deep in the brain can detect harmful electrical waves called cortical spreading depolarizations (CSDs) after a traumatic brain injury (TBI). These waves are thought to cause further damage, but they are hard to detect with …

This study looks at whether measuring nerve signals during a procedure called rhizotomy can help doctors treat trigeminal neuralgia, a condition that causes sudden, severe facial pain. About 30 adults scheduled for this procedure will have their nerve activity recorded. The goal …

This study aims to understand how the vagus nerve works by recording its electrical signals in awake people with epilepsy. Researchers will use a thin needle to listen to nerve activity, both with and without a vagus nerve stimulator device. The goal is to learn which nerve fiber…

This study looks at how a single dose of modafinil changes decision-making and brain activity in healthy adults. Researchers hope to learn more about psychosis spectrum disorders like schizophrenia. Participants will take modafinil, play computer brain games, and wear an EEG cap …

This study looks at how blood flow in the brain and the ability to keep balance change from young adulthood to old age. About 102 healthy adults, split into three age groups, will have their brain activity and balance measured during simple tasks and a short exercise session. The…

This study tests if transplanting healthy gut bacteria (called intestinal microbiota transplantation) is safe for people having colon surgery. Forty adults aged 18-75 with diverticulitis or sigmoid colon cancer will receive the transplant through a feeding tube a few days after s…

This study looks at how the brain works in people with Parkinson's disease who are getting Deep Brain Stimulation (DBS). The goal is to learn more about brain signals related to movement and thinking, which could help make DBS therapy better in the future. About 30 adults with Pa…

This study looks at why young women with post-traumatic stress disorder (PTSD) may have a higher risk of heart disease later in life. Researchers will test if drinking beetroot juice can improve blood vessel function in 30 premenopausal women who have experienced trauma. The goal…

This study tests whether a non-invasive ultrasound technique can accurately image brain tumors before surgery. Researchers will compare ultrasound images to standard MRI scans in 15 adults scheduled for brain surgery. The goal is to see if ultrasound can provide a faster, cheaper…

This study tests whether transplanting gut bacteria from healthy donors, along with antibiotics and fiber, is safe and possible for people with pulmonary arterial hypertension (PAH). 24 adults with PAH will be randomly assigned to receive either the bacteria transplant or a place…

This study looks at how early menopause (before age 45) affects the body's ability to control blood pressure. Researchers will measure nerve activity, heart rate, and blood pressure in 160 women aged 35-70. The goal is to understand why some women develop high blood pressure afte…

This study aims to better understand cognitive rigidity—the tendency to get stuck in repetitive thoughts—in people with depression. Researchers will test online tasks in 2,500 adults to see how these thinking patterns relate to symptoms like loss of interest or pleasure. No treat…

This study is testing a computer tool that helps doctors follow the best guidelines for preventing blood clots in adults with traumatic brain injury. About 15,000 patients across 7 hospitals will take part. The goal is to see if the tool improves how often patients get the right …

This study looks at whether giving transmasculine people a simple educational handout before their surgical consultation helps them feel more confident about deciding to keep or remove their ovaries during a gender-affirming hysterectomy. About 250 participants will be randomly a…

This study looks at how deep brain stimulation (DBS) affects walking and other movements that don't improve with standard Parkinson's medication. About 36 adults with Parkinson's who already have a Medtronic Percept DBS device will take part. Researchers will record brain signals…

This study aims to understand how different brain circuits affect movement and thinking in people with Parkinson's disease who already have a deep brain stimulation (DBS) device. Researchers will measure brain activity patterns during rest and movement, and link them to standard …

This study is looking for better ways to measure how ALS progresses over time. Researchers will use MRI scans of the brain and spine, along with blood tests, to track changes in 90 people with ALS and healthy volunteers over one year. The goal is to find reliable markers that can…

This study follows 100 women aged 45-55 as they go through menopause to see how their nerves and blood vessels change. Researchers measure nerve activity and blood vessel function over several years. The goal is to understand why menopause may increase the risk of high blood pres…

This study tests whether watching a short docudrama film right after donating blood can motivate first-time donors to come back and donate again. About 180 first-time blood donors in Ghana will be split into two groups: one watches the film, the other receives standard informatio…

This study looks at two ways to help prevent behavior problems in children ages 3 to 8. First, it trains primary care doctors to better refer families to parenting programs. Second, it tests an online parenting program called eGen that parents can do from home. The goal is to see…

This study explores what happens to your body's cells and metabolism during a long fast. Researchers will take blood samples from 15 healthy adults before, during, and after a prolonged fast. They will then test how that blood affects breast cancer cells in a lab dish, to see if …

This study explores how a mother's stress may change the makeup of her breastmilk and how that affects feeding and brain development in preterm babies. Researchers will follow 120 preterm infants and their mothers from the NICU to 4 months corrected age. The goal is to better und…

This study compares a new device called CompuFlo CathCheck to the standard X-ray method (epidurogram) for confirming that an epidural catheter is in the right spot. About 50 adults getting epidurals for surgery will participate. The goal is to see if the new device works just as …

This study looks at how the brain adapts in people with REM sleep behavior disorder (RBD), a condition that often leads to Parkinson's disease or similar disorders. Researchers will use brain scans and other tests to track changes over 30 to 36 months in 86 adults with RBD and he…

This study is observing 1,500 adults admitted to the hospital with a suspected or confirmed acute infection. Researchers will collect data and samples to understand how the infection affects people, what treatments work, and how to design better clinical trials in the future. The…

This study tests a new portable 0.7 Tesla MRI scanner that only images the head. Researchers will compare its image quality to standard MRI machines. The study involves 20 healthy adults who are not pregnant and not extremely claustrophobic. The goal is to see if this smaller, po…

This study looks at tiny particles released by cells, called extracellular vesicles, in people with Gaucher disease, carriers, and healthy volunteers. Researchers want to see if these particles are different in size, number, and content, and if they can help explain brain inflamm…

This study follows 40 people with rare DNA repair disorders like Cockayne syndrome, xeroderma pigmentosum, and trichothiodystrophy. Researchers will measure movement, balance, and other health changes over time to better understand how these conditions progress. No new treatments…

This study creates a registry to collect health information from up to 10,000 people who have received or donated an organ at the University of Minnesota. Researchers will track outcomes over time to better understand transplant success and donor health. No new treatments are bei…

This study looks at oxygen levels in the airway during a procedure called rigid bronchoscopy, which uses a breathing machine (jet ventilator) to help patients breathe. Doctors want to know how fast oxygen drops when they switch to a special 'laser mode' that lowers fire risk duri…

This study looks at how tics change during a type of behavior therapy called CBIT for people aged 12 to 21 with chronic tic disorders. Researchers want to find out what factors help predict who will benefit most from the therapy. Participants will complete 8 therapy sessions and …

This study looks at whether a telehealth program called Project REACH can help people who use drugs get HIV prevention and treatment services. About 121 participants will be recruited from syringe service programs. The goal is to see if the program is practical and acceptable, no…

This study aims to find the best settings for deep brain stimulation (DBS) in people with epilepsy that medications cannot control. Researchers will test different combinations of stimulation strength, speed, and pulse width in 20 adults who already have a DBS device. The goal is…

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Researchers will monitor brain activity and sleep quality in 64 adults who already have or will get a DBS device. The goal is to understand which brain pathways control sleep pr…

This study looks at how gentle vibrations on the throat change brain activity and voice quality in people with laryngeal dystonia, a condition that causes involuntary voice spasms. Researchers will use brain scans and voice recordings to understand why some people get relief from…

This study looks at whether using positive or negative words when describing an epidural procedure changes how much pain a person feels. Researchers will compare pain scores in 30 first-time mothers receiving their first epidural. The goal is to see if careful wording can reduce …

This study aims to create detailed brain maps that show where important functions like thinking and effort are located in people with epilepsy. Researchers will use mild electrical stimulation on the brain's surface during hospital monitoring for epilepsy surgery. The goal is to …

This study looks at whether timing brain stimulation with a person's own brain waves can improve treatment for stimulant use disorder. Researchers will use MRI and EEG to find the best spot and timing for stimulation in 50 adults who are already in treatment and have been drug-fr…

This study looks at whether giving radiation therapy after a hand contracture release procedure can improve long-term hand function for people with Dupuytren's disease. Researchers will follow 50 adults who are already getting the standard treatment to see if adding radiation red…

This study looks at how the brain and balance system work together when people with Parkinson's disease start walking, turn, or change speed. Researchers will use gentle electrical stimulation and brain wave recordings to find patterns linked to freezing of gait. The goal is to b…

This early study is testing whether a non-invasive brain stimulation technique called TACS can help improve thinking and decision-making after a mild to moderate traumatic brain injury (TBI). Researchers will enroll 30 adults to see if the approach is feasible and well-tolerated.…

This study uses powerful MRI scans to find biological markers, or 'biomarkers,' for ALS and a related condition called PLS. Researchers will compare brain scans from 30 people—those with ALS, those with PLS, and healthy volunteers—to spot differences that could lead to better tre…

This study looks at how chronic temporomandibular disorder (TMD) pain influences drinking patterns in heavy drinkers. Researchers will compare people with and without jaw pain to see if pain changes how much and how fast they drink, both in a lab setting and in daily life. The go…

This study looks at how spinal manipulation therapy (a type of hands-on adjustment) affects neck movement in people with long-term neck pain. Researchers will measure neck motion in 60 adults aged 18-39 before and after treatment, comparing spinal manipulation to light massage or…

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Participants will complete computer tasks while their brain activity is recorded, and receive m…

This study looks at what happens to the heart and breathing during a hot flush in women after menopause. Researchers will use a special heating pad to try to trigger hot flushes and measure blood pressure, skin temperature, and heart rate. The goal is to understand if hot flushes…

This study watches 300 adults who have open abdominal surgery to learn why some get surgical site infections. Researchers will collect samples from the skin and gut during surgery and track patients for 30 days. By comparing those who get infections with those who don't, they hop…

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or healthy vision will pa…

This study looks at how vagus nerve stimulation (VNS) changes the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. It is not a treatment study—it aims to learn how VNS works. About 144 adults aged 18 and olde…

This study looks at whether walking in nature (parks, preserves) or walking in built-up areas (shopping centers, streets) is better for reducing stress and anxiety in adults with prediabetes. About 216 people aged 25-64 will walk 150 minutes each week for six weeks in each type o…

This study tests whether low-intensity focused ultrasound (LIFU) can improve thinking and memory in healthy adults. Researchers will use brain scans and thinking tests to see if the ultrasound can safely activate deep brain areas. The goal is to understand how ultrasound affects …

This study looks at how different parts of the brain connect in people with long-term jaw pain (TMD) compared to those without pain. Researchers will use MRI scans to find patterns that may explain why pain becomes chronic. The goal is to better understand the condition, not to t…