University Of Minnesota

This study compared daily fasting to traditional calorie restriction for weight loss in 115 obese adults. Participants followed either a fasting schedule or reduced their daily calories for 12 weeks. The goal was to see if fasting is a practical alternative for people who struggl…

This study looked at the best way to use weight-loss medications for teenagers with severe obesity who did not lose enough weight through diet and exercise alone. About 150 teens aged 12-17 took part. The goal was to see if changing when or how the medicine is given could help th…

This study tested whether a full-mouth electronic toothbrush (FMET) works better than a regular electronic toothbrush for reducing gum inflammation and plaque. 94 adults with mild to moderate gingivitis took part. The FMET was used with either standard toothpaste or a foam system…

This pilot study tested whether adding a GLP-1 drug (semaglutide) to insulin helps overweight adults with cystic fibrosis-related diabetes lose weight and improve blood sugar control. Eight participants took the drug for 12 weeks. The study aimed to see if the drug is safe and to…

This study looked at whether time-restricted eating (eating only during a set daily window) can help manage blood sugar and weight in adults with type 2 diabetes. Over 24 weeks, 115 overweight or obese participants on metformin tried TRE without counting calories. The goal was to…

This pilot study tested a program called FAM for adults with type 1 diabetes who are at risk for diabetic ketoacidosis (DKA). The program involved sharing real-time glucose data with a family member or friend (the "Follower") and giving personalized diabetes education to both the…

This study tested whether giving low-dose iron pills to people in Ghana who were turned away from donating blood due to low hemoglobin could help them donate successfully. Over 500 participants were split into two groups: one received iron supplements plus nutrition advice, the o…

This study tested three common drugs—metformin, ivermectin, and fluvoxamine—in over 1,300 adults with early COVID-19 to see if they could prevent severe illness or long-term symptoms. Participants were not hospitalized and had a higher body weight. The key finding was that metfor…

This study tested whether limiting eating to a 10-12 hour window each day (time-restricted eating) helps parents and children lose weight. 36 parent-child pairs were randomly assigned to either time-restricted eating or standard healthy eating advice. Over 12 weeks, both groups r…

This study looked at whether waiving fees for youth sports programs and adding extra family support helps low-income children ages 6-12 get more physical activity. Over 400 kids from 20 parks in Minneapolis and Saint Paul took part. Researchers measured their activity with accele…

This study tested whether giving a drug called abatacept early to hospitalized COVID-19 patients on low-flow oxygen could help them recover faster. The drug aims to calm an overactive immune response. 285 adults with COVID-19 pneumonia took part. The main goal was to see if abata…

This early study tested whether a thin, clear membrane from the back of the cornea (Descemet's membrane) can be placed on the eye's surface to help it heal in people with limbal stem cell deficiency, a condition that can cause blindness. Nineteen adults with partial or total stem…

This study tested three formats (online, in-person group, and telehealth) of a parenting program called ADAPT for military families where a parent recently returned from deployment. The goal was to see which format best improves parenting skills and reduces children's risk for be…

This study tested a new portable ultrasound device that takes a single heart image in under a minute from the chest area. It involved 22 infants under 1 year old with congenital heart disease. The goal was to see if the quick images were as clear and useful as standard heart ultr…

This early-phase study tested whether giving a combination of plasmapheresis (a blood-filtering procedure) and the drug rituximab before or at the time of kidney transplant could prevent focal segmental glomerulosclerosis (FSGS) from recurring. The study enrolled 21 children and …

This study tested whether taking fecal microbiota transplant (FMT) capsules could help prevent Crohn's disease from returning after surgery. 23 adults with Crohn's who had surgery received FMT either by capsules or colonoscopy. The goal was to see if the capsules could deliver th…

This study tested a support program for 95 caregivers of family members who have both traumatic brain injury and dementia. The program included education and counseling to help caregivers manage stress, communicate better, and feel more confident in their role. The goal was to re…

This study tested whether offering free legal services to people with advanced colorectal cancer could reduce stress and financial worries. Twenty participants received personalized legal help from a nonprofit for six months. Researchers measured changes in stress, coping, and qu…

This study tested a non-invasive treatment called neurofeedback in 157 teens who had attempted suicide. Participants learned to control their own brain activity in real time using an MRI scanner. The goal was to see if this training could reduce suicidal thoughts and improve emot…

This study tested a mobile app called OPY that helps patients manage pain and safely use opioids after surgery. Over 3,400 adults who had outpatient surgery and received an opioid prescription used the app to track pain, get tips, and receive reminders to reduce opioid use. The g…

This study tested whether a longer-lasting pain medicine (liposomal bupivacaine) given as a nerve block before breast surgery could reduce the need for opioid painkillers after surgery compared to the standard medicine (bupivacaine). 112 adults having partial mastectomy took part…

This study tested whether the drug brivaracetam can reduce the severe nerve pain that many people with spinal cord injury experience. About 44 adults with chronic spinal cord injury and persistent nerve pain took either the drug or a placebo for several weeks. Researchers measure…

This pilot study tested whether adding a mild electrical brain stimulation (tDCS) to intensive speech therapy helps people with non-fluent aphasia (trouble speaking after a stroke) improve their ability to talk in sentences and recall words. Ten adults who had a stroke and have a…

This study tested whether injections of Xeomin (a botulinum toxin) into the muscles around the ear can reduce the ringing sensation of tinnitus. 41 adults with persistent tinnitus received either Xeomin or a placebo, and their symptoms were tracked using a standard questionnaire.…

This study looked at 1000 adults with sudden low back pain who were at risk for it becoming a long-term problem. Researchers compared spinal manipulation plus guided self-care against standard medical care. The goal was to see if these treatments could reduce pain and disability …

This study tested whether physical therapy for jaw disorders (TMD) done via video calls works as well as in-person sessions. Over 200 adults with jaw pain or headaches took part. Researchers compared diagnosis accuracy and quality of life improvements to see if virtual care is a …

This study tested a drug called brivaracetam to see if it can help people with long-term spinal cord injury who have severe nerve pain that other treatments haven't helped. 24 adults with spinal cord injury and daily pain rated 9 or 10 out of 10 took the drug or a placebo for 3 m…

This study looked at whether special breathing exercises could help people with Long COVID who have trouble breathing and feel tired. Sixteen adults who had COVID-19 and still had symptoms like shortness of breath and fatigue took part. They did diaphragmatic breathing exercises,…

This early study tested whether a faster schedule of transcranial magnetic stimulation (TMS) could work for major depression. Normally, TMS requires daily visits for weeks, but this study compressed the schedule. 11 adults with depression tried the accelerated approach, and resea…

This study tested a new online coaching system designed to help people adjust to and use their hearing aids more effectively. Researchers enrolled 34 adults with hearing loss to see if adding personalized health and wellness coaching to the hearing aid fitting process would make …

This study tested whether a full-service mobile food market that sells nutritious foods at low prices can improve diet quality and reduce food insecurity in low-income neighborhoods. Researchers enrolled 262 participants from 12 community sites, with half receiving the mobile mar…

This study looked at how past infections and damage to lymph nodes might weaken the body's ability to build long-term protection from the yellow fever vaccine. Researchers studied 43 adults in Uganda and Minnesota, taking blood and lymph node samples before and after vaccination.…

This study tested whether the Club 25 program, where students pledge to donate blood 25 times in their lifetime, increases donation rates compared to standard recruitment. Over 35,000 students from 30 secondary schools in Malawi took part, with half the schools using Club 25. Res…

This study tested a program to help adult men in prison who have sexually abused children avoid doing it again. Ten men took part in the program, which focused on changing risky thoughts and behaviors. Researchers measured things like coping skills and attitudes to see if the pro…

This study used a non-invasive brain stimulation technique called TMS to measure how the motor cortex responds in people who have had a stroke. Researchers compared brain excitability between 24 stroke survivors and healthy individuals. The goal was to better understand how strok…

This study placed a continuous glucose monitor on very preterm babies (born before 31 weeks) to track their blood sugar levels for up to 10 days. The goal was to see how well the device detects high and low blood sugar and to link those readings to the babies' growth and brain de…

This study tested whether brain stimulation works better when people are actively using the brain area being stimulated. 51 healthy adults received transcranial magnetic stimulation (TMS) while doing either a thinking task or a simple perception task. Researchers measured brain a…

This study tested a program called Link for Equity, which trains school staff to be more aware of racism and trauma. The goal was to see if this training could reduce racial/ethnic differences in school violence and discipline. Over 1,600 staff from 12 secondary schools in Minnes…

This study looked at how young adults aged 18-30 with early psychosis process information about their surroundings, compared to those without a psychiatric diagnosis. Researchers used computer-based tasks and cognitive training to measure changes in thinking skills. The goal was …

This study tested a new device that records brain activity while deep brain stimulation (DBS) is turned on during surgery. The goal was to better understand how DBS affects the brain in people with Parkinson's disease. One participant was involved, and the approach used standard …

This study tested simple paper and electronic tools to measure the types of foods available in people's homes, focusing on items that affect health. About 439 English- or Spanish-speaking adults who do most of their household's grocery shopping took part. The goal was to create r…

This study looked at how bacteria travel through the nose, mouth, and lungs of infants with cystic fibrosis. Researchers collected swabs and mucus samples from 7 babies over their first year of life. The goal was to understand which germs are present and how they move, which coul…

This study tested a new program to help Somali families reduce shisha (hookah) smoke inside their homes. Fifteen families took part, and researchers checked if the program was easy to use and if it lowered smoke exposure by measuring cotinine levels. The goal was to see if this a…

This study looked at how people aged 15-45 with early psychosis process information about their surroundings, called state representation. Participants completed computer tasks while their brain activity was measured using EEG and MRI. The goal was to understand brain function di…

This study looked at whether specially trained senior volunteers can help families caring for someone with Alzheimer's or dementia. The goal was to connect families with community services and improve their interactions with doctors. 44 people with dementia and their caregivers t…

This study created a registry of 655 people with Alport syndrome to collect health information over time. The goal is to better understand the disease and lay the groundwork for future treatment studies. Participants provided medical data and family history, but no experimental t…

This study tested two simple ways to encourage first-time blood donors in Ghana to donate again. One group received messages through WhatsApp, another watched a short educational film (docudrama), and a third group got the usual information. Researchers followed 882 participants …

This study aimed to improve genetic counseling for people of all backgrounds. Over 1,000 adults referred for genetic counseling completed surveys and had their sessions recorded. Researchers tested different counseling methods to see which led to better patient experiences, espec…

This study aimed to understand why Black older adults with type 2 diabetes spend long periods sitting and how to help them move more. Researchers worked with 33 participants to design practical strategies for breaking up sedentary time. The goal was to improve heart health and bl…

This study looked at how the timing of brain waves in the prefrontal cortex affects whether people tend to approach or avoid things. Researchers used a technique called TMS-EEG to stimulate the brain at specific moments during theta waves in 26 healthy adults. The goal was to und…

This study looked at whether continuous glucose monitors (CGMS) can help predict low blood sugar (hypoglycemia) in adults with type 2 diabetes. 41 participants wore either a regular or a hidden monitor for a short time while continuing their usual care. The goal was to find new w…

This study tested an online parenting training program called GenerationPMTO to help prevent behavior problems in children. Researchers worked with 94 parents and primary care providers to see if the program could be easily accessed and used. The goal was to improve parenting ski…

This study created a registry and biobank for people with osteosarcoma, a rare bone cancer. Researchers collected genetic samples from 362 participants, including patients and their family members, to compare genes and learn more about the disease. The goal was to support future …

This study looked at how parents and friends help reduce stress in 11-14 year olds. Researchers used brain scans and stress tests to see how social support changes with puberty. The goal was to understand why teens rely less on parents and more on peers as they grow. 208 teens pa…

This study measured levels of certain brain and blood chemicals linked to oxidative stress and inflammation in people with Gaucher disease type 1 and healthy volunteers. The goal was to see if these chemicals are different in Gaucher patients. 33 adults took part, and the study u…

This study looked at how eating too much at different times of day affects inflammation and metabolism in healthy adults. Sixteen volunteers were observed to see if evening overeating is worse than daytime overeating. The goal was to better understand the body's response to overe…

This study looked at how people aged 15-45 with early psychosis process information about their surroundings, compared to those without a psychiatric diagnosis. Researchers tested two types of cognitive training and measured changes in thinking and brain activity using computer t…

This study tested a new afterschool program where college students mentored middle schoolers to help them be more active and improve their mood. The program was designed for teens with depression symptoms who might not normally join afterschool activities. The main goal was to se…

This study looked at whether a home body water analyzer can help detect lymphedema early in women treated for breast cancer. Lymphedema is arm swelling caused by fluid buildup, and catching it early is key because early stages are reversible. Researchers followed 52 women for 12 …

This study tested two ways of training long-term care workers in Minnesota to provide better care for LGBTQ+ residents with Alzheimer's or dementia. Over 760 staff members took part in either in-person or online training. The goal was to see if the training improved staff knowled…

This study tested a program called Home Alone for older adults with memory problems who live by themselves. The goal was to see if the program was helpful and acceptable. Participants worked with a coach in weekly sessions to stay active, engaged, and safe at home. The study invo…

This study looked at how having a parent or a best friend nearby affects a teenager's stress response. Researchers used brain scans and saliva samples to measure stress in 202 teens. The goal was to understand how this 'social buffering' changes as teens grow older.

This study looked at 21 adults with thumb arthritis to see if an 8-week exercise program could improve joint alignment. It also checked if ultrasound could measure joint problems as accurately as a CAT scan. The goal was to find better, non-drug ways to manage thumb arthritis and…

This study looked at why the weight-loss drug topiramate works differently in different teenagers with severe obesity. Researchers used mathematical models to understand how the drug moves through the body and affects weight. The goal was to find ways to personalize dosing for be…

This study tested a program called Link for Equity in 12 Minnesota middle and high schools. The program trains school staff to be more aware of racism and its impact on students, aiming to reduce violence and discipline disparities. About 518 students of color took part, and rese…

This study looked at how the brain develops over time in young teenage girls who have hurt themselves on purpose (non-suicidal self-injury). Researchers used interviews, brain scans (MRI), and thinking tests to learn more about this behavior. The goal was to gather information, n…

This study tested a non-invasive technique called traveling wave brain stimulation in 9 adults with epilepsy who already had electrodes implanted for monitoring. The goal was to see if this gentle electrical stimulation could improve working memory and change how different brain …

This study looked at lungs removed from 74 people with cystic fibrosis during transplant to see how bacteria and chemistry differ from one area to another. Researchers took samples from each lobe and used DNA sequencing to identify which bacteria were present and how active they …

This study looked at what kinds of nicotine replacement products menthol smokers like best when trying to quit. 60 African American adults who smoked menthol cigarettes tried six different products, including mint and non-mint gums and inhalers. After two weeks of trying them, th…