New hope for FSGS patients: preemptive rituximab may stop kidney disease return
NCT ID NCT03763643
First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 24 times
Summary
This early-phase study tested whether giving a combination of plasmapheresis (a blood-filtering procedure) and the drug rituximab before or at the time of kidney transplant could prevent focal segmental glomerulosclerosis (FSGS) from recurring. The study enrolled 21 children and adults aged 1 to 65 who had a confirmed diagnosis of primary FSGS or minimal change disease and a history of nephrotic syndrome. The main goal was to see if this approach was feasible, meaning whether patients could complete all the steps from recruitment to follow-up.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Children's Hospital of Colorado
Aurora, Minnesota, 80045, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Cincinnati Children's Hospital
Cincinnati, Ohio, 45229, United States
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Duke University
Durham, North Carolina, 27708, United States
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Lurie Children's Hospital
Chicago, Illinois, 60611, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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University of Alabama
Tuscaloosa, Alabama, 35487, United States
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University of California at Davis
Davis, California, 95616, United States
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University of Cincinnati
Cincinnati, Ohio, 45221, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Minnesota
Minneapolis, Minnesota, 55455, United States
Conditions
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