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Could a seizure drug ease nerve pain in spinal cord injury?

NCT ID NCT05639946

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 3 trial tested whether brivaracetam, a drug used for seizures, can reduce chronic nerve pain in people with spinal cord injury. 44 adults with persistent pain took part. The study compared brivaracetam to a placebo and measured changes in pain intensity and daily interference over 7 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
brivaracetam
What this could lead to
If it works, this could offer a new medication option for people with spinal cord injury who suffer from hard-to-treat nerve pain.
What could go wrong
This is a small, early-phase trial with only 44 participants. The drug may not reduce pain better than a placebo, and side effects like drowsiness are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

44 people

The number who actually took part.

Started

Jan 2023

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years of age or older * Injured for \> 3 months * Completed inpatient rehabilitation and living in the community * Chronic sublesional neuropathic pain defined as persistent pain (VAS grade 3-10) for three months or more * For people of child-bearing potential: currently practicing an effective form of two types of birth control (defined as those, alone or in combination, that result in a low failure rate (i.e., less than 1% per year) when used consistently and correctly). Exclusion Criteria: * Progressive myelopathy secondary to posttraumatic cord tethering or syringomyelia * Active use of drugs known to interact with brivaracetam: rifampin, carbamazepine, sodium oxybate, buprenorphine, propoxyphene, levetiracetam, and phenytoin. * Brain injury or cognitive impairment limiting the ability to follow directions or provide informed consent * Pregnancy or lactation * Epilepsy or active treatment for seizure disorder * Past or current suicidality * Active treatment for psychiatric disease * Drug addiction * Moderate or heavy alcohol intake (up to four alcoholic drinks for men and three for women in any single day, and a maximum of 14 drinks for men and 7 drinks for women per week) * Hepatic cirrhosis, Child-Pugh grades A, B, and C * Impaired renal function (GFR\<60ml/minute) * Contraindications to brivaracetam or pyrrolidine derivatives including allergy * Active clinically significant disease (e.g., renal, hepatic, neurological, cardiovascular, pulmonary, endocrine, psychiatric, hematologic, urologic, or other acute or chronic illness) that, in the opinion of the investigator, would make the patient an unsuitable candidate for this trial. * History of malabsorption or other gastrointestinal (GI) disease that may significantly alter the absorption of brivaracetam * Use of any investigational drug 30 days prior to enrollment in this study * Enrollment in another clinical trial.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Minnesota

    Minneapolis, Minnesota, 55455, United States

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