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Brain study sheds light on thinking in early psychosis

NCT ID NCT05538832

Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how people aged 18-30 with early psychosis process information about their surroundings, compared to those without a psychiatric diagnosis. Participants completed computer-based tasks and cognitive training. The goal was to better understand thinking patterns in psychosis, not to provide treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

152 people

The number who actually took part.

Started

Jul 2022

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

INCLUSION CRITERIA All Participants: * Between the ages of 18-30 at the time of screening * Fluent in spoken and written English, in that the participant learned to speak English before the age of 12 or is able to demonstrate fluency in conversation with study staff * Has an outpatient status and no hospitalization for psychiatric reasons for at least 1 month prior to participant * Has access to a computer with internet connection * Has a United States address as permanent residence * Estimated IQ at or above 70, as estimated by the cognitive assessments Early Psychosis Participants: * Diagnosis of one of the following conditions (confirmed via interview): schizophrenia; schizoaffective disorder; schizophreniform disorder; Psychosis not otherwise specified (NOS); major depressive disorder with psychotic features; bipolar disorder with psychotic features * Willing to share contact with a clinical provider EXCLUSION CRITERIA All participants: * History of severe substance use in the past 3 months (determined by interview) * Unable to demonstrate capacity to consent to research, in the judgment of the study team * Diagnosed with a neurological disorder that would impede participation in the study or would put the participant at additional risk by participating, in the opinion of the PI/CO-Is * Previous clinically significant head injury or prolonged unconsciousness * Significant cognitive training experience in the past 6 months * Meets criteria for clinical risk of suicidal behavior. Non-Psychosis participants: * Meets DSM-5 criteria for a psychotic, bipolar, or autism spectrum disorder * Has a family history (1st degree relative) of psychosis, bipolar, or autism spectrum disorders

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Conditions

The condition(s) this trial relates to.

Affective Disorders, Psychotic bipolar disorder mood disorder psychotic disorder Psychotic Disorders schizoaffective disorder schizophrenia Schizophrenia Spectrum and Other Psychotic Disorders schizophreniform disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Psychoses, affective Psychosis Psychosis nos/other Psychotic disorders Psychotic mood disorders Schizo affective disorder Schizoaffective disorder Schizophrenia Schizophrenia spectrum and other psychotic disorders Schizophreniform disorders

Contacts and locations

Locations

  • University of Minnesota

    Minneapolis, Minnesota, 55454, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.