University Of Minnesota

This study tests whether a medication called lisdexamfetamine, when combined with healthy lifestyle changes, can help children aged 6 to 12 with severe obesity lose weight. About 44 children will be randomly assigned to receive either the drug or a placebo, along with lifestyle t…

This study tests a program where people with opioid or stimulant use disorder earn small cash rewards for attending doctor visits and providing drug-free urine samples. The goal is to see if this approach helps them stay in treatment and reduce drug use. The study involves 56 adu…

This study tests a practical approach for teens with severe obesity: combining lifestyle counseling with medication. About 120 teens aged 12-17 will receive counseling and a weight-loss drug to see if this combo helps them lose weight more effectively than counseling alone. The g…

This pilot study tests whether the diabetes drug empagliflozin is safe and tolerable for overweight or obese adults with cystic fibrosis-related diabetes (CFRD). Eight participants will receive either the drug or a placebo, then switch after a break. The goal is to gather early d…

This study aimed to test a thyroid hormone (T3) treatment sprayed directly into the lungs of COVID-19 patients with severe breathing failure (ARDS) who were on ventilators. The goal was to reduce lung fluid and improve recovery. However, the trial was withdrawn before any patient…

This study follows 433 people with severe chronic pancreatitis who had surgery to remove the pancreas and transplant their own insulin-making cells (TPIAT). Researchers track pain relief, quality of life, and whether patients can stop taking insulin. The goal is to understand how…

This study tests whether giving a thyroid hormone (T3) directly into the lungs is safe and can improve oxygen levels in adults with acute respiratory distress syndrome (ARDS) who are on a ventilator. About 68 critically ill patients will either receive T3 or standard care. The go…

This study tests a combination of two drugs, phentermine and topiramate, in 13 teenagers aged 12-20 who have both obesity and type 2 diabetes. The goal is to see if the medication can help lower body mass index (BMI) over 6 months. The drug is already approved for adults with obe…

This study tests a mobile health system called mGlide to help people with uncontrolled high blood pressure. About 395 stroke survivors and others at high risk for heart disease will use a wireless blood pressure monitor and smartphone to send daily readings to their healthcare te…

This study tests whether a combination of two drugs, phentermine and topiramate, can help teens aged 12 to 18 with severe obesity maintain weight loss after a meal replacement program. The body often fights weight loss by increasing appetite and slowing metabolism, making it hard…

This study tests a proactive outreach program to help BIPOC adults who smoke quit tobacco. Researchers will use electronic health records to identify smokers and offer culturally tailored support, including counseling and medication. The goal is to reduce smoking rates and relate…

This study planned to test a special pin (Anser Clavicle Pin) for surgically fixing broken collarbones in 50 adults. The goal was to see how well the bone healed and how satisfied patients were. However, the study was withdrawn before any participants were enrolled, so no results…

This study tested whether a treatment made from healthy gut bacteria (called restorative microbiota therapy) is safe and possible for people with severe colon inflammation caused by cancer immunotherapy. It was designed for patients whose colitis did not improve with steroids. Th…

This study tests a new version of electroconvulsive therapy (ECT) for people with treatment-resistant depression. The goal is to reduce memory loss, a common side effect, by placing electrodes on one side of the head to better target the brain's prefrontal cortex. About 20 adults…

This study tests a device that plays sound customized to each person's tinnitus pitch, aiming to make the treatment more comfortable and easier to use. Twenty adults with tinnitus will use the device for 12 weeks, with virtual check-ins to reduce clinic visits. The goal is to see…

This study tests a special WaterPik and brush device to see if it can improve scalp health by massaging and cleansing. About 40 people with dandruff, seborrheic dermatitis, or hair loss will use the device. Researchers will measure changes in flaking and redness to see if the dev…

This study tests a remote program called teleABLE that helps people who had a stroke within the past year reduce their sitting time and improve their quality of life. Participants either receive 12 sessions of teleABLE or 6 sessions of health education. The study involves wearing…

This study tests a digital platform called ConnectedNest that helps cancer patients find and connect with community services for needs like housing, food, and financial help. About 400 adults with cancer from Minnesota clinics will use the platform for 90 days. The goal is to see…

This study tests two community-based self-management programs for adults with chronic back or neck pain. One program teaches mind-body skills like mindfulness and cognitive behavioral techniques, while the other focuses on general health and well-being. Participants attend nine w…

This early-stage study tests a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to people with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. 17 adults currently in tre…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) before and after a type of weight-loss surgery called sleeve gastrectomy. About 30 adults who are overweight and have NASH or prediabetes will take part. Th…

This study explores whether a new program called PA-ChatS can help people become more physically active within the first 6 weeks after a stroke. About 25 participants will wear a Fitbit to track steps and meet weekly with an occupational therapist. The goal is to see if people st…

This study aimed to find out how many people with trigeminal neuralgia (a severe facial nerve pain condition) also have a painful jaw joint disorder called TMD. Researchers planned to follow patients from three clinics and use questionnaires to improve diagnosis. However, the stu…

This study aims to improve magnetic resonance spectroscopy (MRS), a technique that measures brain chemicals without surgery. Researchers will test new methods using stronger MRI magnets (3 to 7 Tesla) in 30 healthy adults. The goal is to get clearer and more detailed images of br…

This study looks at whether a culturally-tailored sexual health training program helps health professional students in Tanzania improve their knowledge, attitudes, and counseling skills. About 310 students from Muhimbili University of Health and Allied Sciences took part. Researc…

This study looks at how special exercises for the tongue and throat muscles might help people with obstructive sleep apnea. Thirty adults with sleep apnea will use myofunctional therapy devices for 3 months. Researchers will measure muscle pressure in the throat to understand why…

This study aims to develop new ways to take and analyze MRI images. It involves 500 healthy adults over age 18. The goal is to improve how MRI works, not to treat any disease. Participants will undergo MRI scans using advanced techniques.

This study looks at why blood clots form in the legs (venous thrombosis) and lungs (pulmonary embolism) in over 21,000 African American and white adults. Researchers are using data from two long-running health studies to find risk factors. The goal is to better understand these c…

This study was designed to measure DNA damage in cells from the mouth of smokers, vapers, and people who never used tobacco or nicotine. The goal was to see which types of damage might be more likely to cause oral cancer. However, the study was withdrawn before any participants w…

This study aimed to understand how people's vision and brain activity change when they wear colored lenses. Participants would have worn tinted lenses while researchers measured their color perception and brain signals. The study was withdrawn before enrolling anyone, so no resul…

This study looks at how placing a stent to widen a narrowed part of the aorta (coarctation) changes the heart's workload. Researchers will use special catheters to measure pressure and volume inside the heart before and after the procedure. The goal is to understand if stenting f…

This study looks at how repeated low blood sugar (hypoglycemia) changes the way the brain uses glucose in people with type 1 diabetes. Researchers will use brain scans to measure these changes in 50 adults who have normal awareness of low blood sugar. The goal is to understand wh…

This study follows 60 Parkinson's disease patients who are scheduled for deep brain stimulation (DBS) surgery. Researchers will track their brain activity, movement, and thinking skills before, during, and after the procedure. The goal is to learn how DBS affects the brain over t…

This study looks at whether a teaching method that directly explains grammar rules works better than a traditional approach that relies on examples and practice. About 155 children aged 5 to 9 with language impairment will take part. The goal is to find the best way to help them …

This study looks at how different tobacco products—like cigarettes, e-cigarettes, and smokeless tobacco—affect the way skin wounds heal. Researchers will measure skin temperature, blood flow, and signs of inflammation in 60 adults, including a group of non-smokers for comparison.…

This study follows 113 people with recent spinal cord injuries to understand how feelings of injustice (like blaming others or feeling cheated) affect their mental health and recovery over one year. Researchers use surveys and interviews to track depression, PTSD, anger, and qual…

This study aimed to see if giving new anesthesia residents access to a library of real intubation videos would help them learn the procedure faster and with less stress. The plan was to compare their success rates and stress levels to those without the video library. However, the…

This study looks at whether a blood test can help doctors see if treatment for kidney rejection is working in children who have had a kidney transplant. About 27 kids will give blood samples to check for special markers. The goal is to find a less invasive way to monitor rejectio…

This study aimed to see if changing the look and feel of HIV clinics in Uganda could reduce stigma and make patients feel more welcome. Researchers planned to update clinic systems and physical spaces to improve privacy and friendliness. However, the study was withdrawn before an…

This study tests whether giving doctors real-time feedback during colonoscopy helps them find more polyps, which can prevent colorectal cancer. Over 4,000 doctors will participate, and the main goal is to see if the feedback improves the rate of polyp detection. The study is curr…

This study looks at how aerobic or yoga training affects the way muscles process fat and sugar, which may influence insulin resistance—a condition that can lead to type 2 diabetes. Researchers will study 64 healthy, lean, or overweight adults before and after a 16-week supervised…

This study looks at whether training volunteers to visit older adults with memory loss or dementia can improve the volunteers' skills and reduce loneliness in the people they visit. About 342 volunteers and clients in Minnesota are taking part. The training is part of the volunte…

This study looks at whether creating special committees made up of hospital staff, community members, and county leaders can help make blood more available for transfusions in Kenyan hospitals. The researchers are testing this approach in 9 hospitals across three different counti…

This study looks at whether a bedside ultrasound can accurately measure body fat and muscle in healthy premature babies in the NICU. Researchers will compare ultrasound results with other proven methods to see if it can track weekly changes in body composition. The goal is to hel…

This study aimed to see if a non-invasive brain stimulation technique called cTBS could reduce cravings in people recovering from methamphetamine use disorder. Researchers planned to enroll 40 adults living in a residential treatment program and use brain scans to measure changes…