Weight loss pill combo may help teens keep pounds off

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Severe obesity (BMI \>/= 120% of the 95th percentile or BMI \>/= 35 kg/m2) * Age 12 to \< 18 years of age at enrollment (screening) and Tanner stage \>/= 2 - Female participants who are sexually active with males and who are able to get pregnant must agree to use two forms of contraception throughout the trial Exclusion Criteria: * Diabetes (type 1 or 2) * Current or recent (\< six months prior to enrollment) use of anti-obesity medication(s) defined as orlistat, phentermine, topiramate, combination phentermine/topiramate, liraglutide, and/or combination naltrexone/bupropion (monotherapy use of naltrexone or bupropion is not an exclusion) * Previous metabolic/bariatric surgery * Current use of a stimulant medication * History of glaucoma * Current or recent (\<14 days) use of monoamine oxidase inhibitor * Known hypersensitivity to sympathomimetic amines * Any history of treatment with growth hormone * Any history of bulimia nervosa * Major psychiatric disorder as determined by the local medical monitor * Unstable and clinically-diagnosed (defined as documented in the medical record, if available) depression * Any history of active suicide attempt * History of suicidal ideation or self-harm within the previous 30 days of screening * Patient Health Questionnaire (PHQ-9) score \>15 at screening * Current pregnancy or plans to become pregnant during study participation * Current tobacco use * Alanine transaminase (ALT) or Aspartate transaminase (AST) \>/= 3 times the upper limit of normal * Bicarbonate \<18 mmol/L * Creatinine \> 1.2 mg/dL * Any history of seizures * Uncontrolled hypertension as determined by the local medical monitor * History of structural heart defect or clinically significant arrhythmia * Diagnosed monogenic obesity * Any history of cholelithiasis * Any history of nephrolithiasis * Clinically diagnosed hyperthyroidism * Untreated thyroid disorder * Any disorder, unwillingness, or inability, not covered by any other exclusion criteria, which in the investigator's opinion, might jeopardize the subject's safety or compliance with the protocol